Medication adherence and quality of life in epilepsy patients

Nurulumi Ahmad, Nurul Izaty Othaman, Farida Hanim Islahudin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Adherence to antiepileptic drugs is vital in maintaining control of seizure. This is even more important in epilepsy as poor seizure control directly affects daily productivity. Objective: The aim of this study is to assess the adherence intention towards pharmacotherapy and its impact on quality of life in epilepsy patients. Method: This prospective, cross-sectional study was conducted in a local tertiary hospital. Ethical approval was obtained from the Medical Research and Ethics Committee. Adults diagnosed with epilepsy and treated with at least one antiepileptic drug was included in the study with informed consent. Demographic data, frequency of seizures and medication were collected from patient medical records. Adherence intention was evaluated using the Modified Morisky Adherence Scale. Quality of life was evaluated using Quality of Life in Epilepsy Patient Weighted-10 questionnaire (QOLIE-10). Results: A total of 52 patients were included in the study. There was a negative correlation between complexity of medication with seizure control (R=-0.33, p=0.017). Only 21.2% (n=11) achieved high adherence intention in the study population. Furthermore, good seizure control was found to improve patient quality of life (F=4.067, p=0.012). Similarly, a higher adherence intention also improved quality of life (F=4.161, p=0.021). Conclusion: This study demonstrates that adherence intention has a significant impact on patient quality of life. Therefore, adherence intention should be monitored to provide appropriate support in improving quality of life in epilepsy patients.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume5
Issue numberSUPPL. 2
Publication statusPublished - 2013

Fingerprint

Medication Adherence
Epilepsy
Quality of Life
Seizures
Anticonvulsants
Medical Ethics
Research Ethics Committees
Informed Consent
Tertiary Care Centers
Medical Records
Biomedical Research
Cross-Sectional Studies
Demography
Drug Therapy
Population

Keywords

  • Adherence
  • Epilepsy
  • Quality of life
  • Seizure

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Medication adherence and quality of life in epilepsy patients. / Ahmad, Nurulumi; Izaty Othaman, Nurul; Islahudin, Farida Hanim.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 5, No. SUPPL. 2, 2013, p. 401-404.

Research output: Contribution to journalArticle

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