Mechanisms of diabetes-induced liver damage: The role of oxidative stress and inflammation

Jamaludin Mohamed, A. H. Nazratun Nafizah, Zariyantey Abd Hamid, Siti Balkis Budin

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to nonalcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokines—including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α—exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.

Original languageEnglish
Pages (from-to)e132-e141
JournalSultan Qaboos University Medical Journal
Volume16
Issue number2
DOIs
Publication statusPublished - 1 May 2016

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Oxidative Stress
Inflammation
Liver
Metabolic Diseases
Carbohydrate Metabolism
Fatty Liver
Malondialdehyde
Interleukin-1
Lipid Metabolism
Developed Countries
Hyperglycemia
Developing Countries
Insulin Resistance
Hepatocytes
Hepatocellular Carcinoma
Interleukin-6
Diabetes Mellitus
Fibrosis
Tumor Necrosis Factor-alpha
Genes

Keywords

  • Diabetes mellitus
  • Inflammation
  • Liver diseases
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanisms of diabetes-induced liver damage : The role of oxidative stress and inflammation. / Mohamed, Jamaludin; Nazratun Nafizah, A. H.; Abd Hamid, Zariyantey; Budin, Siti Balkis.

In: Sultan Qaboos University Medical Journal, Vol. 16, No. 2, 01.05.2016, p. e132-e141.

Research output: Contribution to journalArticle

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