Abstract
To evaluate the oral protein delivery potential of pH-responsive bacterial cellulose-based hydrogels, a model protein drug was efficiently loaded into the hydrogels and the release profile was investigated in a simulated gastric fluid (SGF) and a simulated intestinal fluid (SIF). In this study, we will propose a mathematical approach to evaluating the performance of the hydrogels in the simulated gastrointestinal fluids. We start by using the power law to determine the type of the release in each fluid. Then, the swelling behaviour of the hydrogel will be studied and the least squares method will be developed to find a suitable mathematical function to represent the growth. Mathematical models for the release will be developed and solved to be used to find the concentration of the protein at a given time. The mathematical procedures for diffusion coefficient determination in SIF and SGF will be concluded in an algorithm at the end of this paper.
| Original language | English |
|---|---|
| Pages (from-to) | 15-26 |
| Number of pages | 12 |
| Journal | Malaysian Journal of Mathematical Sciences |
| Volume | 10 |
| Publication status | Published - 2016 |
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Keywords
- Controlled drug delivery
- Effective diffusion coefficient
- Hydrogel
- Swelling
ASJC Scopus subject areas
- Mathematics(all)
Cite this
Mathematical model for estimating the diffusion coefficients of protein release from bacterial cellulose-based hydrogel. / Mahali, Shalela Mohd; Saudi, Muhamad Hakimi; Mohd Amin, Mohd Cairul Iqbal; Abdullah, Ilyani; Ahmad, Naveed.
In: Malaysian Journal of Mathematical Sciences, Vol. 10, 2016, p. 15-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mathematical model for estimating the diffusion coefficients of protein release from bacterial cellulose-based hydrogel
AU - Mahali, Shalela Mohd
AU - Saudi, Muhamad Hakimi
AU - Mohd Amin, Mohd Cairul Iqbal
AU - Abdullah, Ilyani
AU - Ahmad, Naveed
PY - 2016
Y1 - 2016
N2 - To evaluate the oral protein delivery potential of pH-responsive bacterial cellulose-based hydrogels, a model protein drug was efficiently loaded into the hydrogels and the release profile was investigated in a simulated gastric fluid (SGF) and a simulated intestinal fluid (SIF). In this study, we will propose a mathematical approach to evaluating the performance of the hydrogels in the simulated gastrointestinal fluids. We start by using the power law to determine the type of the release in each fluid. Then, the swelling behaviour of the hydrogel will be studied and the least squares method will be developed to find a suitable mathematical function to represent the growth. Mathematical models for the release will be developed and solved to be used to find the concentration of the protein at a given time. The mathematical procedures for diffusion coefficient determination in SIF and SGF will be concluded in an algorithm at the end of this paper.
AB - To evaluate the oral protein delivery potential of pH-responsive bacterial cellulose-based hydrogels, a model protein drug was efficiently loaded into the hydrogels and the release profile was investigated in a simulated gastric fluid (SGF) and a simulated intestinal fluid (SIF). In this study, we will propose a mathematical approach to evaluating the performance of the hydrogels in the simulated gastrointestinal fluids. We start by using the power law to determine the type of the release in each fluid. Then, the swelling behaviour of the hydrogel will be studied and the least squares method will be developed to find a suitable mathematical function to represent the growth. Mathematical models for the release will be developed and solved to be used to find the concentration of the protein at a given time. The mathematical procedures for diffusion coefficient determination in SIF and SGF will be concluded in an algorithm at the end of this paper.
KW - Controlled drug delivery
KW - Effective diffusion coefficient
KW - Hydrogel
KW - Swelling
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UR - http://www.scopus.com/inward/citedby.url?scp=85012257899&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85012257899
VL - 10
SP - 15
EP - 26
JO - Malaysian Journal of Mathematical Sciences
JF - Malaysian Journal of Mathematical Sciences
SN - 1823-8343
ER -