Maternal thyroid function in women undergoing controlled ovarian hyperstimulation during in-vitro fertilization and its relation to reproductive outcome

Abdul Karim, Muhammad Azraibu, Buvanes Chelliah, Zainul Rashid Mohd. Razi, Mohd Hashim Omar, Hanita O. Thman, Zuraidah C. Man

Research output: Contribution to journalArticle

Abstract

BACKGROUND: We conducted a study to evaluate the changes in thyroid function during controlled ovarian hyperstimulation (COH) and its association with the outcome of assisted reproductive technique (ART). METHODS: This is a prospective cohort study done in University Hospital Fertility Clinic for one year duration. Atotal of 88 euthyroid women who underwent COH as part of planned in-vitro fertilization (IVF) were invited to participate in this study. Serum thyroid function of each women will be monitored before stimulation (T1), day 10-13 of cycle (T2), during oocyte retrieval (T3), one week following embryo transfer (T4), and at four weeks after embryo transfer (T5). Reproductive outcome of IVF will be observed and documented. RESULTS: Nine women had ongoing singleton pregnancy, seven suffered from miscarriage, while the rest had implantation failure. Serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) increased throughout stimulation, peaking at 32-36 hours after hCG administration compared to baseline (1.250 vs. 1.740 mIU/Land 13.94 vs. 15.25 pmol/L). It remains elevated until one week following embryo transfer. The increment of serum TSH exceeded the upper limit, acceptable for first trimester (<1.60 mIU/L). However, the evolution of serum TSH and fT4 did not significantly differ with pregnancy outcome. CONCLUSIONS: In euthyroid women, thyroid function changed significantly during COH, but these changes were not different between the three reproductive outcomes. Thus, we do not suggest continuous thyroid function monitoring during COH.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalMinerva Ginecologica
Volume69
Issue number5
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Fertilization in Vitro
Embryo Transfer
Thyroid Gland
Thyrotropin
Mothers
Serum
Oocyte Retrieval
Assisted Reproductive Techniques
Spontaneous Abortion
First Pregnancy Trimester
Pregnancy Outcome
Thyroxine
Fertility
Cohort Studies
Prospective Studies
Pregnancy

Keywords

  • Assisted reproductive techniques
  • Fertilization in vitro
  • Infertility
  • Ovulation induction
  • Thyroid gland

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Maternal thyroid function in women undergoing controlled ovarian hyperstimulation during in-vitro fertilization and its relation to reproductive outcome. / Karim, Abdul; Azraibu, Muhammad; Chelliah, Buvanes; Mohd. Razi, Zainul Rashid; Omar, Mohd Hashim; Thman, Hanita O.; Man, Zuraidah C.

In: Minerva Ginecologica, Vol. 69, No. 5, 01.10.2017, p. 431-437.

Research output: Contribution to journalArticle

Karim, Abdul ; Azraibu, Muhammad ; Chelliah, Buvanes ; Mohd. Razi, Zainul Rashid ; Omar, Mohd Hashim ; Thman, Hanita O. ; Man, Zuraidah C. / Maternal thyroid function in women undergoing controlled ovarian hyperstimulation during in-vitro fertilization and its relation to reproductive outcome. In: Minerva Ginecologica. 2017 ; Vol. 69, No. 5. pp. 431-437.
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AU - Karim, Abdul

AU - Azraibu, Muhammad

AU - Chelliah, Buvanes

AU - Mohd. Razi, Zainul Rashid

AU - Omar, Mohd Hashim

AU - Thman, Hanita O.

AU - Man, Zuraidah C.

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N2 - BACKGROUND: We conducted a study to evaluate the changes in thyroid function during controlled ovarian hyperstimulation (COH) and its association with the outcome of assisted reproductive technique (ART). METHODS: This is a prospective cohort study done in University Hospital Fertility Clinic for one year duration. Atotal of 88 euthyroid women who underwent COH as part of planned in-vitro fertilization (IVF) were invited to participate in this study. Serum thyroid function of each women will be monitored before stimulation (T1), day 10-13 of cycle (T2), during oocyte retrieval (T3), one week following embryo transfer (T4), and at four weeks after embryo transfer (T5). Reproductive outcome of IVF will be observed and documented. RESULTS: Nine women had ongoing singleton pregnancy, seven suffered from miscarriage, while the rest had implantation failure. Serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) increased throughout stimulation, peaking at 32-36 hours after hCG administration compared to baseline (1.250 vs. 1.740 mIU/Land 13.94 vs. 15.25 pmol/L). It remains elevated until one week following embryo transfer. The increment of serum TSH exceeded the upper limit, acceptable for first trimester (<1.60 mIU/L). However, the evolution of serum TSH and fT4 did not significantly differ with pregnancy outcome. CONCLUSIONS: In euthyroid women, thyroid function changed significantly during COH, but these changes were not different between the three reproductive outcomes. Thus, we do not suggest continuous thyroid function monitoring during COH.

AB - BACKGROUND: We conducted a study to evaluate the changes in thyroid function during controlled ovarian hyperstimulation (COH) and its association with the outcome of assisted reproductive technique (ART). METHODS: This is a prospective cohort study done in University Hospital Fertility Clinic for one year duration. Atotal of 88 euthyroid women who underwent COH as part of planned in-vitro fertilization (IVF) were invited to participate in this study. Serum thyroid function of each women will be monitored before stimulation (T1), day 10-13 of cycle (T2), during oocyte retrieval (T3), one week following embryo transfer (T4), and at four weeks after embryo transfer (T5). Reproductive outcome of IVF will be observed and documented. RESULTS: Nine women had ongoing singleton pregnancy, seven suffered from miscarriage, while the rest had implantation failure. Serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) increased throughout stimulation, peaking at 32-36 hours after hCG administration compared to baseline (1.250 vs. 1.740 mIU/Land 13.94 vs. 15.25 pmol/L). It remains elevated until one week following embryo transfer. The increment of serum TSH exceeded the upper limit, acceptable for first trimester (<1.60 mIU/L). However, the evolution of serum TSH and fT4 did not significantly differ with pregnancy outcome. CONCLUSIONS: In euthyroid women, thyroid function changed significantly during COH, but these changes were not different between the three reproductive outcomes. Thus, we do not suggest continuous thyroid function monitoring during COH.

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