Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice

Renuka Gunasekaran, Mohammed Rafid Shaker, Siti Waheeda Mohd-Zin, Aminah Abdullah, Azlina Ahmad-Annuar, Noraishah Mydin Abdul-Aziz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Coconut oil is commonly used as herbal medicine worldwide. There is limited information regarding its effects on the developing embryo and infant growth. Methods: We investigated the effect of virgin coconut oil post-natally and until 6 weeks old in mice (age of maturity). Females were fed with either standard, virgin olive oil or virgin coconut oil diets 1 month prior to copulation, during gestation and continued until weaning of pups. Subsequently, groups of pups borne of the respective diets were continuously fed the same diet as its mother from weaning until 6 weeks old. Profiles of the standard and coconut oil diets were analysed by gas chromatography flame ionization detector (GCFID). Results: Analysis of the mean of the total weight gained/ loss over 6 weeks revealed that in the first 3 weeks, pups whose mothers were fed virgin coconut oil and virgin olive oil have a significantly lower body weight than that of standard diet pups. At 6 weeks of age, only virgin coconut oil fed pups exhibited significantly lower body weight. We report that virgin coconut oil modifies the fatty acid profiles of the standard diet by inducing high levels of medium chain fatty acids with low levels of essential fatty acids. Furthermore, pups borne by females fed with virgin coconut oil developed spiky fur. Conclusion: Our study has demonstrated that virgin coconut oil could affect infant growth and appearance via maternal intake; we suggest the use of virgin coconut oil as herbal medicine to be treated with caution.

Original languageEnglish
Article number79
JournalBMC Complementary and Alternative Medicine
Volume17
Issue number1
DOIs
Publication statusPublished - 28 Jan 2017

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Essential Fatty Acids
Body Weight
Mothers
Diet
Herbal Medicine
Weaning
Fatty Acids
coconut oil
Flame Ionization
Copulation
Growth
Gas Chromatography
Weight Loss
Embryonic Structures
Pregnancy

Keywords

  • Body weight
  • Coconut oil
  • Essential fatty acids
  • GCFID
  • Spiky fur

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice. / Gunasekaran, Renuka; Shaker, Mohammed Rafid; Mohd-Zin, Siti Waheeda; Abdullah, Aminah; Ahmad-Annuar, Azlina; Abdul-Aziz, Noraishah Mydin.

In: BMC Complementary and Alternative Medicine, Vol. 17, No. 1, 79, 28.01.2017.

Research output: Contribution to journalArticle

Gunasekaran, Renuka ; Shaker, Mohammed Rafid ; Mohd-Zin, Siti Waheeda ; Abdullah, Aminah ; Ahmad-Annuar, Azlina ; Abdul-Aziz, Noraishah Mydin. / Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice. In: BMC Complementary and Alternative Medicine. 2017 ; Vol. 17, No. 1.
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