Management and Outcomes Following Surgery for Gastrointestinal Typhoid: An International, Prospective, Multicentre Cohort Study

Collaborative Globalsurg Collaborative, Thomas M. Drake, James Glasbey, J. Edward Fitzgerald, Riinu Ots, Ewen M. Harrison, Stephen Tabiri, Aneel Bhangu, Adesoji O. Ademuyiwa, Maria Lorena Aguilera, Philip Alexander, Sara W. Al-Saqqa, Giuliano Borda-Luque, Ainhoa Costas-Chavarri, Thomas M. Drake, Faustin Ntirenganya, J. Edward Fitzgerald, Stuart J. Fergusson, James Glasbey, J. C. Allen IngabireLawani Ismaïl, Hosni Khairy Salem, Anyomih Theophilus Teddy Kojo, Marie Carmela Lapitan, Richard Lilford, Andre L. Mihaljevic, Dion Morton, Alphonse Zeta Mutabazi, Dmitri Nepogodiev, Adewale O. Adisa, Riinu Ots, Francesco Pata, Thomas Pinkney, Tomas Poškus, Ahmad Uzair Qureshi, Antonio Ramos De la Medina, Sarah Rayne, Catherine A. Shaw, Sebastian Shu, Richard Spence, Neil Smart, Stephen Tabiri, Ewen M. Harrison, A. O. Ademuyiwa, S. Tabiri, Cutting Edge Manipal, M. Mohan, J. Jeyakumar, Ashrarur Rahman Mitul, Khalid Mahmud, Margub Hussain, Hafiz Hakim, Tapan Kumar, Antje Oosterkamp, Francis Abantanga, Kwaku Boakye-Yiadom, Mohammed Bukari, Frank Owusu, Joseph Awuku-Asabre, Stephen Tabiri, Lemuel Davies Bray, S. S. Prasad, Anand Kirishnan, Nidhi Gyanchandani, Bylapudi Seshu Kumar, Muthukumaran Rangarajan, Sriram Bhat, Anjana Sreedharan, S. V. Kinnera, Yella Reddy, Caranj Venugopal, Sunil Kumar, Abhishek Mittal, Shravan Nadkarni, Harish Neelamraju Lakshmi, Puneet Malik, Neel Limaye, Srinivas Pai, Pratik Jain, Monty Khajanchi, Savni Satoskar, Rajeev Satoskar, Abid Bin Mahamood, Ross Coomber, Kenneth Johnson, Jennifer Nowers, Aminu Mohammad, Lofty John Anyanwu, Abdulrahman Sheshe, Alaba Adesina, Olubukola Faturoti, Ogechukwu Taiwo, Muhammad Habib Ibrahim, Abdulrasheed A. Nasir, Siyaka Itopa Suleiman, Adewale Adeniyi, Opeoluwa Adesanya, Ademola Adebanjo, Omolara Williams, Kazeem Atobatele, Ayokunle Ogunyemi, Mobolaji Oludara, Olabode Oshodi, Roland Osuoji, Adesoji Ademuyiwa, Abdul Razzaq Oluwagbemiga Lawal, Felix Alakaloko, Olumide Elebute, Adedapo Osinowo, Christopher Bode, Abidemi Adesuyi, Adesoji Tade, Adeleke Adekoya, Collins Nwokoro, Omobolaji O. Ayandipo, Taiwo Akeem Lawal, Akinlabi E. Ajao, Samuel Sani Ali, Babatunde Odeyemi, Samson Olori, Ademola Popoola, Ademola Adeyeye, James Adeniran, Kamran Faisal Bhopal, Zainab Iftikhar, Muhammad Mohsin Furqan, Bakhtiar Nighat, Masood Jawaid, Abdul Khalique, Ahsan Zil-E-Ali, Anam Rashid, Hasnain Abbas Dharamshi, Tahira Naqvi, Ahmad Faraz, Abdul Wahid Anwar, Tahir Muhammad Yaseen, Ghina Shamim Shamsi, Ghina Shamsi, Tahir Yaseen, Wahid Anwer, Prasad Pitigala Arachchi, Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha Senanayake, Lalith Asanka Jayasooriya Jayasooriya Arachchige, Sivasuriya Sivaganesh, Dulan Irusha Samaraweera, Vimalakanthan Thanusan, Lawani Ismaïl, Stephen Tabiri, Yong Yong Tew, Adesoji O. Ademuyiwa, Tanzeela Gala, Fernande Djivoh, Lawani Ismaïl, Francis Dossou, Djifid Morel Seto, Dansou Gaspard Gbessi, Bruno Noukpozounkou, Yacoubou Imorou Souaibou, Kpèmahouton René Keke, Fred Hodonou, Ernest Yemalin Stephane Ahounou, Thierry Alihonou, Max Dénakpo, Germain Ahlonsou, Stephen Tabiri, Anyomih Theophilus Teddy Kojo, Dickson Bandoh, Francis Abantanga, Martin Kyereh, Hamza Asumah, Eric Kofi Appiah, Paul Wondoh, Adam Gyedu, Charles Dally, Kwabena Agbedinu, Michael Amoah, Abiboye Yifieyeh, Frank Owusu, Mabel Amoako-Boateng, Makafui Dayie, Richmond Hagan, Sam Debrah, Micheal Ohene-Yeboah, Joe Nat Clegg-Lampety, Victor Etwire, Jonathan Dakubo, Samuel Essoun, William Bonney, Hope Glover-Addy, Samuel Osei-Nketiah, Joachim Amoako, Niiarmah Adu-Aryee, William Appeadu-Mensah, Antoinette Bediako-Bowan, Florence Dedey, Mattew Ekow, Emmanuel Akatibo, Musah Yakubu, Hope Edem Kofi Kordorwu, Kwasi Asare-Bediako, Enoch Tackie, Kenneth Aaniana, Emmanuel Acquah, Richard Opoku-Agyeman, Anthony Avoka, Kwasi Kusi, Kwame Maison, Frank Enoch Gyamfi, Gandau Naa Barnabas, Saiba Abdul-Latif, Philip Taah Amoako, Anthony Davor, Victor Dassah, Enoch Dagoe, Prince Kwakyeafriyie, Elliot Akoto, Eric Ackom, Ekow Mensah, Ebenezer Takyi Atkins, Christian Lari Coompson, Taha Yusufali, Hussein Mohammed, Justus Lando, Robert Parker, Wairimu Ndegwa, Feng Yih Chai, Siti Mohd Desa Asilah, Khuzaimah Zahid Syibrah, Pui Xin Chin, Afizah Salleh, Nur Zulaika Riswan, April Camilla Roslani, Hoong Yin Chong, Nora Abdul Aziz, Keat Seong Poh, Chu Ann Chai, Sandip Kumar, Mustafa Mohammed Taher, Nik Ritza Kosai, Dayang Nita Abdul Aziz, Reynu Rajan, Rokayah Julaihi, Durvesh Lacthman Jethwani, Muhammad Taqiyuddin Yahaya, Nik Azim Nik Abdullah, Susan Wndy Mathew, Kuet Jun Chung, Milaksh Kumar Nirumal, R. Goh Ern Tze, Syed Abdul Wahhab Eusoffee Wan Ali, Yiing Yee Gan, Jesse Ron Swire Ting, Samuel S.Y. Sii, Kean Leong Koay, Yi Koon Tan, Alvin Ee Zhiun Cheah, Chui Yee Wong, Tuan Nur’Azmah Tuan Mat, Crystal Yern Nee Chow, Prisca A.L. Har, Yishan Der, Yong Yong Tew, Fitjerald Henry, Xinwei Low, Ya Theng Neo, Hian Ee Heng, Shu Ning Kong, Cheewei Gan, Yi Ting Mok, Yee Wen Tan, Kandasami Palayan, Mahadevan Deva Tata, Yih Jeng Cheong, Kuhaendran Gunaseelan, Wan Nurul ‘Ain Wan Mohd Nasir, Pigeneswaren Yoganathan, Eu Xian Lee, Jian Er Saw, Li Jing Yeang, Pei Ying Koh, Shyang Yee Lim, Shuang Yi Teo, Akinlabi Ajao, Omobolaji Ayandipo, Taiwo Lawal, Abdussemiu Abdurrazzaaq, Muslimat Alada, Abdulrasheed Nasir, James Adeniran, Olufemi Habeeb, Ademola Popoola, Ademola Adeyeye, Ademola Adebanjo, Opeoluwa Adesanya, Adewale Adeniyi, Henry Mendel, Bashir Bello, Umar Muktar, Adedapo Osinowo, Thomas Olagboyega Olajide, Oyindamola Oshati, George Ihediwa, Babajide Adenekan, Victor Nwinee, Felix Alakaloko, Adesoji Ademuyiwa, Olumide Elebute, Abdulrazzaq Lawal, Chris Bode, Mojolaoluwa Olugbemi, Alaba Adesina, Olubukola Faturoti, Oluwatomi Odutola, Oluwaseyi Adebola, Clement Onuoha, Ogechukwu Taiwo, Omolara Williams, Fatai Balogun, Olalekan Ajai, Mobolaji Oludara, Iloba Njokanma, Roland Osuoji, Stephen Kache, Jonathan Ajah, Jerry Makama, Ahmed Adamu, Suleiman Baba, Mohammad Aliyu, Shamsudeen Aliyu, Yahaya Ukwenya, Halima Aliyu, Tunde Sholadoye, Muhammad Daniyan, Oluseyi Ogunsua, Lofty John Anyanwu, Abdurrahaman Sheshe, Aminu Mohammad, Samson Olori, Philip Mshelbwala, Babatunde Odeyemi, Garba Samson, Oyediran Kehinde Timothy, Sani Ali Samuel, Anthony Ajiboye, Ademola Adeyeye, Isaac Amole, Olajide Abiola, Akin Olaolorun, Najwa Nadeem, Muhammad Saqlain, Jibran Abbasy, Abdul Rehman Alvi, Tanzeela Gala, Noman Shahzad, Kamran Faisal Bhopal, Zainab Iftikhar, Muhammad Talha Butt, Syed Asaat Ul Razi, Asdaq Ahmed, Ali Khan Niazi, Ibrahim Raza, Fatima Baluch, Ahmed Raza, Ahmad Bani-Sadar, Ahmad Uzair Qureshi, Muhammad Adil, Awais Raza, Mahnoor Javaid, Muhammad Waqar, Maryam Ali Khan, Mohammad Mohsin Arshad, Mohammadasim Amjad, J. C. Allen Ingabire, Alphonse Zeta Mutabazi, Norbert Uzabumwana, Dieudonne Duhoranenayo, Joe Nat Clegg-Lamptey, Osman Imoro, Owusu Emmanuel Abem, Paul Wondoh, Danjuma Sale, Lawal Abdullahi, Olabisi Osagie, Omolara Faboya, Adedeji Fatuga, Agboola Taiwo, Emeka Nwabuoku, Zain Ali Khan, Jennifer Rickard, Choy Ling Tan, Jia Yng Siaw, Sir Young Yam, Ling Wilson, Mohamed Rezal Abdul Aziz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Gastrointestinal perforation is the most serious complication of typhoid fever, with a high disease burden in low-income countries. Reliable, prospective, contemporary surgical outcome data are scarce in these settings. This study aimed to investigate surgical outcomes following surgery for intestinal typhoid. Methods: Two multicentre, international prospective cohort studies of consecutive patients undergoing surgery for gastrointestinal typhoid perforation were conducted. Outcomes were measured at 30 days and included mortality, surgical site infection, organ space infection and reintervention rate. Multilevel logistic regression models were used to adjust for clinically plausible explanatory variables. Effect estimates are expressed as odds ratios (ORs) alongside their corresponding 95% confidence intervals. Results: A total of 88 patients across the GlobalSurg 1 and GlobalSurg 2 studies were included, from 11 countries. Children comprised 38.6% (34/88) of included patients. Most patients (87/88) had intestinal perforation. The 30-day mortality rate was 9.1% (8/88), which was higher in children (14.7 vs. 5.6%). Surgical site infection was common, at 67.0% (59/88). Organ site infection was common, with 10.2% of patients affected. An ASA grade of III and above was a strong predictor of 30-day post-operative mortality, at the univariable level and following adjustment for explanatory variables (OR 15.82, 95% CI 1.53–163.57, p = 0.021). Conclusions: With high mortality and complication rates, outcomes from surgery for intestinal typhoid remain poor. Future studies in this area should focus on sustainable interventions which can reduce perioperative morbidity. At a policy level, improving these outcomes will require both surgical and public health system advances.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalWorld Journal of Surgery
DOIs
Publication statusAccepted/In press - 3 May 2018

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Typhoid Fever
Multicenter Studies
Cohort Studies
Surgical Wound Infection
Mortality
Logistic Models
Odds Ratio
Intestinal Perforation
Infection
Public Health
Prospective Studies
Confidence Intervals
Morbidity

ASJC Scopus subject areas

  • Surgery

Cite this

Globalsurg Collaborative, C., Drake, T. M., Glasbey, J., Fitzgerald, J. E., Ots, R., Harrison, E. M., ... Aziz, M. R. A. (Accepted/In press). Management and Outcomes Following Surgery for Gastrointestinal Typhoid: An International, Prospective, Multicentre Cohort Study. World Journal of Surgery, 1-10. https://doi.org/10.1007/s00268-018-4624-8

Management and Outcomes Following Surgery for Gastrointestinal Typhoid : An International, Prospective, Multicentre Cohort Study. / Globalsurg Collaborative, Collaborative; Drake, Thomas M.; Glasbey, James; Fitzgerald, J. Edward; Ots, Riinu; Harrison, Ewen M.; Tabiri, Stephen; Bhangu, Aneel; Ademuyiwa, Adesoji O.; Aguilera, Maria Lorena; Alexander, Philip; Al-Saqqa, Sara W.; Borda-Luque, Giuliano; Costas-Chavarri, Ainhoa; Drake, Thomas M.; Ntirenganya, Faustin; Fitzgerald, J. Edward; Fergusson, Stuart J.; Glasbey, James; Allen Ingabire, J. C.; Ismaïl, Lawani; Salem, Hosni Khairy; Kojo, Anyomih Theophilus Teddy; Lapitan, Marie Carmela; Lilford, Richard; Mihaljevic, Andre L.; Morton, Dion; Mutabazi, Alphonse Zeta; Nepogodiev, Dmitri; Adisa, Adewale O.; Ots, Riinu; Pata, Francesco; Pinkney, Thomas; Poškus, Tomas; Qureshi, Ahmad Uzair; la Medina, Antonio Ramos De; Rayne, Sarah; Shaw, Catherine A.; Shu, Sebastian; Spence, Richard; Smart, Neil; Tabiri, Stephen; Harrison, Ewen M.; Ademuyiwa, A. O.; Tabiri, S.; Manipal, Cutting Edge; Mohan, M.; Jeyakumar, J.; Mitul, Ashrarur Rahman; Mahmud, Khalid; Hussain, Margub; Hakim, Hafiz; Kumar, Tapan; Oosterkamp, Antje; Abantanga, Francis; Boakye-Yiadom, Kwaku; Bukari, Mohammed; Owusu, Frank; Awuku-Asabre, Joseph; Tabiri, Stephen; Bray, Lemuel Davies; Prasad, S. S.; Kirishnan, Anand; Gyanchandani, Nidhi; Kumar, Bylapudi Seshu; Rangarajan, Muthukumaran; Bhat, Sriram; Sreedharan, Anjana; Kinnera, S. V.; Reddy, Yella; Venugopal, Caranj; Kumar, Sunil; Mittal, Abhishek; Nadkarni, Shravan; Lakshmi, Harish Neelamraju; Malik, Puneet; Limaye, Neel; Pai, Srinivas; Jain, Pratik; Khajanchi, Monty; Satoskar, Savni; Satoskar, Rajeev; Mahamood, Abid Bin; Coomber, Ross; Johnson, Kenneth; Nowers, Jennifer; Mohammad, Aminu; Anyanwu, Lofty John; Sheshe, Abdulrahman; Adesina, Alaba; Faturoti, Olubukola; Taiwo, Ogechukwu; Ibrahim, Muhammad Habib; Nasir, Abdulrasheed A.; Suleiman, Siyaka Itopa; Adeniyi, Adewale; Adesanya, Opeoluwa; Adebanjo, Ademola; Williams, Omolara; Atobatele, Kazeem; Ogunyemi, Ayokunle; Oludara, Mobolaji; Oshodi, Olabode; Osuoji, Roland; Ademuyiwa, Adesoji; Lawal, Abdul Razzaq Oluwagbemiga; Alakaloko, Felix; Elebute, Olumide; Osinowo, Adedapo; Bode, Christopher; Adesuyi, Abidemi; Tade, Adesoji; Adekoya, Adeleke; Nwokoro, Collins; Ayandipo, Omobolaji O.; Lawal, Taiwo Akeem; Ajao, Akinlabi E.; Ali, Samuel Sani; Odeyemi, Babatunde; Olori, Samson; Popoola, Ademola; Adeyeye, Ademola; Adeniran, James; Bhopal, Kamran Faisal; Iftikhar, Zainab; Furqan, Muhammad Mohsin; Nighat, Bakhtiar; Jawaid, Masood; Khalique, Abdul; Zil-E-Ali, Ahsan; Rashid, Anam; Dharamshi, Hasnain Abbas; Naqvi, Tahira; Faraz, Ahmad; Anwar, Abdul Wahid; Yaseen, Tahir Muhammad; Shamsi, Ghina Shamim; Shamsi, Ghina; Yaseen, Tahir; Anwer, Wahid; Arachchi, Prasad Pitigala; Senanayake, Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha; Arachchige, Lalith Asanka Jayasooriya Jayasooriya; Sivaganesh, Sivasuriya; Samaraweera, Dulan Irusha; Thanusan, Vimalakanthan; Ismaïl, Lawani; Tabiri, Stephen; Tew, Yong Yong; Ademuyiwa, Adesoji O.; Gala, Tanzeela; Djivoh, Fernande; Ismaïl, Lawani; Dossou, Francis; Seto, Djifid Morel; Gbessi, Dansou Gaspard; Noukpozounkou, Bruno; Souaibou, Yacoubou Imorou; Keke, Kpèmahouton René; Hodonou, Fred; Ahounou, Ernest Yemalin Stephane; Alihonou, Thierry; Dénakpo, Max; Ahlonsou, Germain; Tabiri, Stephen; Kojo, Anyomih Theophilus Teddy; Bandoh, Dickson; Abantanga, Francis; Kyereh, Martin; Asumah, Hamza; Appiah, Eric Kofi; Wondoh, Paul; Gyedu, Adam; Dally, Charles; Agbedinu, Kwabena; Amoah, Michael; Yifieyeh, Abiboye; Owusu, Frank; Amoako-Boateng, Mabel; Dayie, Makafui; Hagan, Richmond; Debrah, Sam; Ohene-Yeboah, Micheal; Clegg-Lampety, Joe Nat; Etwire, Victor; Dakubo, Jonathan; Essoun, Samuel; Bonney, William; Glover-Addy, Hope; Osei-Nketiah, Samuel; Amoako, Joachim; Adu-Aryee, Niiarmah; Appeadu-Mensah, William; Bediako-Bowan, Antoinette; Dedey, Florence; Ekow, Mattew; Akatibo, Emmanuel; Yakubu, Musah; Kordorwu, Hope Edem Kofi; Asare-Bediako, Kwasi; Tackie, Enoch; Aaniana, Kenneth; Acquah, Emmanuel; Opoku-Agyeman, Richard; Avoka, Anthony; Kusi, Kwasi; Maison, Kwame; Gyamfi, Frank Enoch; Barnabas, Gandau Naa; Abdul-Latif, Saiba; Amoako, Philip Taah; Davor, Anthony; Dassah, Victor; Dagoe, Enoch; Kwakyeafriyie, Prince; Akoto, Elliot; Ackom, Eric; Mensah, Ekow; Atkins, Ebenezer Takyi; Coompson, Christian Lari; Yusufali, Taha; Mohammed, Hussein; Lando, Justus; Parker, Robert; Ndegwa, Wairimu; Chai, Feng Yih; Asilah, Siti Mohd Desa; Syibrah, Khuzaimah Zahid; Chin, Pui Xin; Salleh, Afizah; Riswan, Nur Zulaika; Roslani, April Camilla; Chong, Hoong Yin; Aziz, Nora Abdul; Poh, Keat Seong; Chai, Chu Ann; Kumar, Sandip; Taher, Mustafa Mohammed; Kosai, Nik Ritza; Aziz, Dayang Nita Abdul; Rajan, Reynu; Julaihi, Rokayah; Jethwani, Durvesh Lacthman; Yahaya, Muhammad Taqiyuddin; Abdullah, Nik Azim Nik; Mathew, Susan Wndy; Chung, Kuet Jun; Nirumal, Milaksh Kumar; Goh Ern Tze, R.; Ali, Syed Abdul Wahhab Eusoffee Wan; Gan, Yiing Yee; Ting, Jesse Ron Swire; Sii, Samuel S.Y.; Koay, Kean Leong; Tan, Yi Koon; Cheah, Alvin Ee Zhiun; Wong, Chui Yee; Mat, Tuan Nur’Azmah Tuan; Chow, Crystal Yern Nee; Har, Prisca A.L.; Der, Yishan; Tew, Yong Yong; Henry, Fitjerald; Low, Xinwei; Neo, Ya Theng; Heng, Hian Ee; Kong, Shu Ning; Gan, Cheewei; Mok, Yi Ting; Tan, Yee Wen; Palayan, Kandasami; Tata, Mahadevan Deva; Cheong, Yih Jeng; Gunaseelan, Kuhaendran; Nasir, Wan Nurul ‘Ain Wan Mohd; Yoganathan, Pigeneswaren; Lee, Eu Xian; Saw, Jian Er; Yeang, Li Jing; Koh, Pei Ying; Lim, Shyang Yee; Teo, Shuang Yi; Ajao, Akinlabi; Ayandipo, Omobolaji; Lawal, Taiwo; Abdurrazzaaq, Abdussemiu; Alada, Muslimat; Nasir, Abdulrasheed; Adeniran, James; Habeeb, Olufemi; Popoola, Ademola; Adeyeye, Ademola; Adebanjo, Ademola; Adesanya, Opeoluwa; Adeniyi, Adewale; Mendel, Henry; Bello, Bashir; Muktar, Umar; Osinowo, Adedapo; Olajide, Thomas Olagboyega; Oshati, Oyindamola; Ihediwa, George; Adenekan, Babajide; Nwinee, Victor; Alakaloko, Felix; Ademuyiwa, Adesoji; Elebute, Olumide; Lawal, Abdulrazzaq; Bode, Chris; Olugbemi, Mojolaoluwa; Adesina, Alaba; Faturoti, Olubukola; Odutola, Oluwatomi; Adebola, Oluwaseyi; Onuoha, Clement; Taiwo, Ogechukwu; Williams, Omolara; Balogun, Fatai; Ajai, Olalekan; Oludara, Mobolaji; Njokanma, Iloba; Osuoji, Roland; Kache, Stephen; Ajah, Jonathan; Makama, Jerry; Adamu, Ahmed; Baba, Suleiman; Aliyu, Mohammad; Aliyu, Shamsudeen; Ukwenya, Yahaya; Aliyu, Halima; Sholadoye, Tunde; Daniyan, Muhammad; Ogunsua, Oluseyi; Anyanwu, Lofty John; Sheshe, Abdurrahaman; Mohammad, Aminu; Olori, Samson; Mshelbwala, Philip; Odeyemi, Babatunde; Samson, Garba; Timothy, Oyediran Kehinde; Samuel, Sani Ali; Ajiboye, Anthony; Adeyeye, Ademola; Amole, Isaac; Abiola, Olajide; Olaolorun, Akin; Nadeem, Najwa; Saqlain, Muhammad; Abbasy, Jibran; Alvi, Abdul Rehman; Gala, Tanzeela; Shahzad, Noman; Bhopal, Kamran Faisal; Iftikhar, Zainab; Butt, Muhammad Talha; Razi, Syed Asaat Ul; Ahmed, Asdaq; Niazi, Ali Khan; Raza, Ibrahim; Baluch, Fatima; Raza, Ahmed; Bani-Sadar, Ahmad; Qureshi, Ahmad Uzair; Adil, Muhammad; Raza, Awais; Javaid, Mahnoor; Waqar, Muhammad; Khan, Maryam Ali; Arshad, Mohammad Mohsin; Amjad, Mohammadasim; Allen Ingabire, J. C.; Mutabazi, Alphonse Zeta; Uzabumwana, Norbert; Duhoranenayo, Dieudonne; Clegg-Lamptey, Joe Nat; Imoro, Osman; Abem, Owusu Emmanuel; Wondoh, Paul; Sale, Danjuma; Abdullahi, Lawal; Osagie, Olabisi; Faboya, Omolara; Fatuga, Adedeji; Taiwo, Agboola; Nwabuoku, Emeka; Khan, Zain Ali; Rickard, Jennifer; Tan, Choy Ling; Siaw, Jia Yng; Yam, Sir Young; Wilson, Ling; Aziz, Mohamed Rezal Abdul.

In: World Journal of Surgery, 03.05.2018, p. 1-10.

Research output: Contribution to journalArticle

Globalsurg Collaborative, C, Drake, TM, Glasbey, J, Fitzgerald, JE, Ots, R, Harrison, EM, Tabiri, S, Bhangu, A, Ademuyiwa, AO, Aguilera, ML, Alexander, P, Al-Saqqa, SW, Borda-Luque, G, Costas-Chavarri, A, Drake, TM, Ntirenganya, F, Fitzgerald, JE, Fergusson, SJ, Glasbey, J, Allen Ingabire, JC, Ismaïl, L, Salem, HK, Kojo, ATT, Lapitan, MC, Lilford, R, Mihaljevic, AL, Morton, D, Mutabazi, AZ, Nepogodiev, D, Adisa, AO, Ots, R, Pata, F, Pinkney, T, Poškus, T, Qureshi, AU, la Medina, ARD, Rayne, S, Shaw, CA, Shu, S, Spence, R, Smart, N, Tabiri, S, Harrison, EM, Ademuyiwa, AO, Tabiri, S, Manipal, CE, Mohan, M, Jeyakumar, J, Mitul, AR, Mahmud, K, Hussain, M, Hakim, H, Kumar, T, Oosterkamp, A, Abantanga, F, Boakye-Yiadom, K, Bukari, M, Owusu, F, Awuku-Asabre, J, Tabiri, S, Bray, LD, Prasad, SS, Kirishnan, A, Gyanchandani, N, Kumar, BS, Rangarajan, M, Bhat, S, Sreedharan, A, Kinnera, SV, Reddy, Y, Venugopal, C, Kumar, S, Mittal, A, Nadkarni, S, Lakshmi, HN, Malik, P, Limaye, N, Pai, S, Jain, P, Khajanchi, M, Satoskar, S, Satoskar, R, Mahamood, AB, Coomber, R, Johnson, K, Nowers, J, Mohammad, A, Anyanwu, LJ, Sheshe, A, Adesina, A, Faturoti, O, Taiwo, O, Ibrahim, MH, Nasir, AA, Suleiman, SI, Adeniyi, A, Adesanya, O, Adebanjo, A, Williams, O, Atobatele, K, Ogunyemi, A, Oludara, M, Oshodi, O, Osuoji, R, Ademuyiwa, A, Lawal, ARO, Alakaloko, F, Elebute, O, Osinowo, A, Bode, C, Adesuyi, A, Tade, A, Adekoya, A, Nwokoro, C, Ayandipo, OO, Lawal, TA, Ajao, AE, Ali, SS, Odeyemi, B, Olori, S, Popoola, A, Adeyeye, A, Adeniran, J, Bhopal, KF, Iftikhar, Z, Furqan, MM, Nighat, B, Jawaid, M, Khalique, A, Zil-E-Ali, A, Rashid, A, Dharamshi, HA, Naqvi, T, Faraz, A, Anwar, AW, Yaseen, TM, Shamsi, GS, Shamsi, G, Yaseen, T, Anwer, W, Arachchi, PP, Senanayake, WSMKJ, Arachchige, LAJJ, Sivaganesh, S, Samaraweera, DI, Thanusan, V, Ismaïl, L, Tabiri, S, Tew, YY, Ademuyiwa, AO, Gala, T, Djivoh, F, Ismaïl, L, Dossou, F, Seto, DM, Gbessi, DG, Noukpozounkou, B, Souaibou, YI, Keke, KR, Hodonou, F, Ahounou, EYS, Alihonou, T, Dénakpo, M, Ahlonsou, G, Tabiri, S, Kojo, ATT, Bandoh, D, Abantanga, F, Kyereh, M, Asumah, H, Appiah, EK, Wondoh, P, Gyedu, A, Dally, C, Agbedinu, K, Amoah, M, Yifieyeh, A, Owusu, F, Amoako-Boateng, M, Dayie, M, Hagan, R, Debrah, S, Ohene-Yeboah, M, Clegg-Lampety, JN, Etwire, V, Dakubo, J, Essoun, S, Bonney, W, Glover-Addy, H, Osei-Nketiah, S, Amoako, J, Adu-Aryee, N, Appeadu-Mensah, W, Bediako-Bowan, A, Dedey, F, Ekow, M, Akatibo, E, Yakubu, M, Kordorwu, HEK, Asare-Bediako, K, Tackie, E, Aaniana, K, Acquah, E, Opoku-Agyeman, R, Avoka, A, Kusi, K, Maison, K, Gyamfi, FE, Barnabas, GN, Abdul-Latif, S, Amoako, PT, Davor, A, Dassah, V, Dagoe, E, Kwakyeafriyie, P, Akoto, E, Ackom, E, Mensah, E, Atkins, ET, Coompson, CL, Yusufali, T, Mohammed, H, Lando, J, Parker, R, Ndegwa, W, Chai, FY, Asilah, SMD, Syibrah, KZ, Chin, PX, Salleh, A, Riswan, NZ, Roslani, AC, Chong, HY, Aziz, NA, Poh, KS, Chai, CA, Kumar, S, Taher, MM, Kosai, NR, Aziz, DNA, Rajan, R, Julaihi, R, Jethwani, DL, Yahaya, MT, Abdullah, NAN, Mathew, SW, Chung, KJ, Nirumal, MK, Goh Ern Tze, R, Ali, SAWEW, Gan, YY, Ting, JRS, Sii, SSY, Koay, KL, Tan, YK, Cheah, AEZ, Wong, CY, Mat, TNAT, Chow, CYN, Har, PAL, Der, Y, Tew, YY, Henry, F, Low, X, Neo, YT, Heng, HE, Kong, SN, Gan, C, Mok, YT, Tan, YW, Palayan, K, Tata, MD, Cheong, YJ, Gunaseelan, K, Nasir, WNAWM, Yoganathan, P, Lee, EX, Saw, JE, Yeang, LJ, Koh, PY, Lim, SY, Teo, SY, Ajao, A, Ayandipo, O, Lawal, T, Abdurrazzaaq, A, Alada, M, Nasir, A, Adeniran, J, Habeeb, O, Popoola, A, Adeyeye, A, Adebanjo, A, Adesanya, O, Adeniyi, A, Mendel, H, Bello, B, Muktar, U, Osinowo, A, Olajide, TO, Oshati, O, Ihediwa, G, Adenekan, B, Nwinee, V, Alakaloko, F, Ademuyiwa, A, Elebute, O, Lawal, A, Bode, C, Olugbemi, M, Adesina, A, Faturoti, O, Odutola, O, Adebola, O, Onuoha, C, Taiwo, O, Williams, O, Balogun, F, Ajai, O, Oludara, M, Njokanma, I, Osuoji, R, Kache, S, Ajah, J, Makama, J, Adamu, A, Baba, S, Aliyu, M, Aliyu, S, Ukwenya, Y, Aliyu, H, Sholadoye, T, Daniyan, M, Ogunsua, O, Anyanwu, LJ, Sheshe, A, Mohammad, A, Olori, S, Mshelbwala, P, Odeyemi, B, Samson, G, Timothy, OK, Samuel, SA, Ajiboye, A, Adeyeye, A, Amole, I, Abiola, O, Olaolorun, A, Nadeem, N, Saqlain, M, Abbasy, J, Alvi, AR, Gala, T, Shahzad, N, Bhopal, KF, Iftikhar, Z, Butt, MT, Razi, SAU, Ahmed, A, Niazi, AK, Raza, I, Baluch, F, Raza, A, Bani-Sadar, A, Qureshi, AU, Adil, M, Raza, A, Javaid, M, Waqar, M, Khan, MA, Arshad, MM, Amjad, M, Allen Ingabire, JC, Mutabazi, AZ, Uzabumwana, N, Duhoranenayo, D, Clegg-Lamptey, JN, Imoro, O, Abem, OE, Wondoh, P, Sale, D, Abdullahi, L, Osagie, O, Faboya, O, Fatuga, A, Taiwo, A, Nwabuoku, E, Khan, ZA, Rickard, J, Tan, CL, Siaw, JY, Yam, SY, Wilson, L & Aziz, MRA 2018, 'Management and Outcomes Following Surgery for Gastrointestinal Typhoid: An International, Prospective, Multicentre Cohort Study', World Journal of Surgery, pp. 1-10. https://doi.org/10.1007/s00268-018-4624-8
Globalsurg Collaborative, Collaborative ; Drake, Thomas M. ; Glasbey, James ; Fitzgerald, J. Edward ; Ots, Riinu ; Harrison, Ewen M. ; Tabiri, Stephen ; Bhangu, Aneel ; Ademuyiwa, Adesoji O. ; Aguilera, Maria Lorena ; Alexander, Philip ; Al-Saqqa, Sara W. ; Borda-Luque, Giuliano ; Costas-Chavarri, Ainhoa ; Drake, Thomas M. ; Ntirenganya, Faustin ; Fitzgerald, J. Edward ; Fergusson, Stuart J. ; Glasbey, James ; Allen Ingabire, J. C. ; Ismaïl, Lawani ; Salem, Hosni Khairy ; Kojo, Anyomih Theophilus Teddy ; Lapitan, Marie Carmela ; Lilford, Richard ; Mihaljevic, Andre L. ; Morton, Dion ; Mutabazi, Alphonse Zeta ; Nepogodiev, Dmitri ; Adisa, Adewale O. ; Ots, Riinu ; Pata, Francesco ; Pinkney, Thomas ; Poškus, Tomas ; Qureshi, Ahmad Uzair ; la Medina, Antonio Ramos De ; Rayne, Sarah ; Shaw, Catherine A. ; Shu, Sebastian ; Spence, Richard ; Smart, Neil ; Tabiri, Stephen ; Harrison, Ewen M. ; Ademuyiwa, A. O. ; Tabiri, S. ; Manipal, Cutting Edge ; Mohan, M. ; Jeyakumar, J. ; Mitul, Ashrarur Rahman ; Mahmud, Khalid ; Hussain, Margub ; Hakim, Hafiz ; Kumar, Tapan ; Oosterkamp, Antje ; Abantanga, Francis ; Boakye-Yiadom, Kwaku ; Bukari, Mohammed ; Owusu, Frank ; Awuku-Asabre, Joseph ; Tabiri, Stephen ; Bray, Lemuel Davies ; Prasad, S. S. ; Kirishnan, Anand ; Gyanchandani, Nidhi ; Kumar, Bylapudi Seshu ; Rangarajan, Muthukumaran ; Bhat, Sriram ; Sreedharan, Anjana ; Kinnera, S. V. ; Reddy, Yella ; Venugopal, Caranj ; Kumar, Sunil ; Mittal, Abhishek ; Nadkarni, Shravan ; Lakshmi, Harish Neelamraju ; Malik, Puneet ; Limaye, Neel ; Pai, Srinivas ; Jain, Pratik ; Khajanchi, Monty ; Satoskar, Savni ; Satoskar, Rajeev ; Mahamood, Abid Bin ; Coomber, Ross ; Johnson, Kenneth ; Nowers, Jennifer ; Mohammad, Aminu ; Anyanwu, Lofty John ; Sheshe, Abdulrahman ; Adesina, Alaba ; Faturoti, Olubukola ; Taiwo, Ogechukwu ; Ibrahim, Muhammad Habib ; Nasir, Abdulrasheed A. ; Suleiman, Siyaka Itopa ; Adeniyi, Adewale ; Adesanya, Opeoluwa ; Adebanjo, Ademola ; Williams, Omolara ; Atobatele, Kazeem ; Ogunyemi, Ayokunle ; Oludara, Mobolaji ; Oshodi, Olabode ; Osuoji, Roland ; Ademuyiwa, Adesoji ; Lawal, Abdul Razzaq Oluwagbemiga ; Alakaloko, Felix ; Elebute, Olumide ; Osinowo, Adedapo ; Bode, Christopher ; Adesuyi, Abidemi ; Tade, Adesoji ; Adekoya, Adeleke ; Nwokoro, Collins ; Ayandipo, Omobolaji O. ; Lawal, Taiwo Akeem ; Ajao, Akinlabi E. ; Ali, Samuel Sani ; Odeyemi, Babatunde ; Olori, Samson ; Popoola, Ademola ; Adeyeye, Ademola ; Adeniran, James ; Bhopal, Kamran Faisal ; Iftikhar, Zainab ; Furqan, Muhammad Mohsin ; Nighat, Bakhtiar ; Jawaid, Masood ; Khalique, Abdul ; Zil-E-Ali, Ahsan ; Rashid, Anam ; Dharamshi, Hasnain Abbas ; Naqvi, Tahira ; Faraz, Ahmad ; Anwar, Abdul Wahid ; Yaseen, Tahir Muhammad ; Shamsi, Ghina Shamim ; Shamsi, Ghina ; Yaseen, Tahir ; Anwer, Wahid ; Arachchi, Prasad Pitigala ; Senanayake, Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha ; Arachchige, Lalith Asanka Jayasooriya Jayasooriya ; Sivaganesh, Sivasuriya ; Samaraweera, Dulan Irusha ; Thanusan, Vimalakanthan ; Ismaïl, Lawani ; Tabiri, Stephen ; Tew, Yong Yong ; Ademuyiwa, Adesoji O. ; Gala, Tanzeela ; Djivoh, Fernande ; Ismaïl, Lawani ; Dossou, Francis ; Seto, Djifid Morel ; Gbessi, Dansou Gaspard ; Noukpozounkou, Bruno ; Souaibou, Yacoubou Imorou ; Keke, Kpèmahouton René ; Hodonou, Fred ; Ahounou, Ernest Yemalin Stephane ; Alihonou, Thierry ; Dénakpo, Max ; Ahlonsou, Germain ; Tabiri, Stephen ; Kojo, Anyomih Theophilus Teddy ; Bandoh, Dickson ; Abantanga, Francis ; Kyereh, Martin ; Asumah, Hamza ; Appiah, Eric Kofi ; Wondoh, Paul ; Gyedu, Adam ; Dally, Charles ; Agbedinu, Kwabena ; Amoah, Michael ; Yifieyeh, Abiboye ; Owusu, Frank ; Amoako-Boateng, Mabel ; Dayie, Makafui ; Hagan, Richmond ; Debrah, Sam ; Ohene-Yeboah, Micheal ; Clegg-Lampety, Joe Nat ; Etwire, Victor ; Dakubo, Jonathan ; Essoun, Samuel ; Bonney, William ; Glover-Addy, Hope ; Osei-Nketiah, Samuel ; Amoako, Joachim ; Adu-Aryee, Niiarmah ; Appeadu-Mensah, William ; Bediako-Bowan, Antoinette ; Dedey, Florence ; Ekow, Mattew ; Akatibo, Emmanuel ; Yakubu, Musah ; Kordorwu, Hope Edem Kofi ; Asare-Bediako, Kwasi ; Tackie, Enoch ; Aaniana, Kenneth ; Acquah, Emmanuel ; Opoku-Agyeman, Richard ; Avoka, Anthony ; Kusi, Kwasi ; Maison, Kwame ; Gyamfi, Frank Enoch ; Barnabas, Gandau Naa ; Abdul-Latif, Saiba ; Amoako, Philip Taah ; Davor, Anthony ; Dassah, Victor ; Dagoe, Enoch ; Kwakyeafriyie, Prince ; Akoto, Elliot ; Ackom, Eric ; Mensah, Ekow ; Atkins, Ebenezer Takyi ; Coompson, Christian Lari ; Yusufali, Taha ; Mohammed, Hussein ; Lando, Justus ; Parker, Robert ; Ndegwa, Wairimu ; Chai, Feng Yih ; Asilah, Siti Mohd Desa ; Syibrah, Khuzaimah Zahid ; Chin, Pui Xin ; Salleh, Afizah ; Riswan, Nur Zulaika ; Roslani, April Camilla ; Chong, Hoong Yin ; Aziz, Nora Abdul ; Poh, Keat Seong ; Chai, Chu Ann ; Kumar, Sandip ; Taher, Mustafa Mohammed ; Kosai, Nik Ritza ; Aziz, Dayang Nita Abdul ; Rajan, Reynu ; Julaihi, Rokayah ; Jethwani, Durvesh Lacthman ; Yahaya, Muhammad Taqiyuddin ; Abdullah, Nik Azim Nik ; Mathew, Susan Wndy ; Chung, Kuet Jun ; Nirumal, Milaksh Kumar ; Goh Ern Tze, R. ; Ali, Syed Abdul Wahhab Eusoffee Wan ; Gan, Yiing Yee ; Ting, Jesse Ron Swire ; Sii, Samuel S.Y. ; Koay, Kean Leong ; Tan, Yi Koon ; Cheah, Alvin Ee Zhiun ; Wong, Chui Yee ; Mat, Tuan Nur’Azmah Tuan ; Chow, Crystal Yern Nee ; Har, Prisca A.L. ; Der, Yishan ; Tew, Yong Yong ; Henry, Fitjerald ; Low, Xinwei ; Neo, Ya Theng ; Heng, Hian Ee ; Kong, Shu Ning ; Gan, Cheewei ; Mok, Yi Ting ; Tan, Yee Wen ; Palayan, Kandasami ; Tata, Mahadevan Deva ; Cheong, Yih Jeng ; Gunaseelan, Kuhaendran ; Nasir, Wan Nurul ‘Ain Wan Mohd ; Yoganathan, Pigeneswaren ; Lee, Eu Xian ; Saw, Jian Er ; Yeang, Li Jing ; Koh, Pei Ying ; Lim, Shyang Yee ; Teo, Shuang Yi ; Ajao, Akinlabi ; Ayandipo, Omobolaji ; Lawal, Taiwo ; Abdurrazzaaq, Abdussemiu ; Alada, Muslimat ; Nasir, Abdulrasheed ; Adeniran, James ; Habeeb, Olufemi ; Popoola, Ademola ; Adeyeye, Ademola ; Adebanjo, Ademola ; Adesanya, Opeoluwa ; Adeniyi, Adewale ; Mendel, Henry ; Bello, Bashir ; Muktar, Umar ; Osinowo, Adedapo ; Olajide, Thomas Olagboyega ; Oshati, Oyindamola ; Ihediwa, George ; Adenekan, Babajide ; Nwinee, Victor ; Alakaloko, Felix ; Ademuyiwa, Adesoji ; Elebute, Olumide ; Lawal, Abdulrazzaq ; Bode, Chris ; Olugbemi, Mojolaoluwa ; Adesina, Alaba ; Faturoti, Olubukola ; Odutola, Oluwatomi ; Adebola, Oluwaseyi ; Onuoha, Clement ; Taiwo, Ogechukwu ; Williams, Omolara ; Balogun, Fatai ; Ajai, Olalekan ; Oludara, Mobolaji ; Njokanma, Iloba ; Osuoji, Roland ; Kache, Stephen ; Ajah, Jonathan ; Makama, Jerry ; Adamu, Ahmed ; Baba, Suleiman ; Aliyu, Mohammad ; Aliyu, Shamsudeen ; Ukwenya, Yahaya ; Aliyu, Halima ; Sholadoye, Tunde ; Daniyan, Muhammad ; Ogunsua, Oluseyi ; Anyanwu, Lofty John ; Sheshe, Abdurrahaman ; Mohammad, Aminu ; Olori, Samson ; Mshelbwala, Philip ; Odeyemi, Babatunde ; Samson, Garba ; Timothy, Oyediran Kehinde ; Samuel, Sani Ali ; Ajiboye, Anthony ; Adeyeye, Ademola ; Amole, Isaac ; Abiola, Olajide ; Olaolorun, Akin ; Nadeem, Najwa ; Saqlain, Muhammad ; Abbasy, Jibran ; Alvi, Abdul Rehman ; Gala, Tanzeela ; Shahzad, Noman ; Bhopal, Kamran Faisal ; Iftikhar, Zainab ; Butt, Muhammad Talha ; Razi, Syed Asaat Ul ; Ahmed, Asdaq ; Niazi, Ali Khan ; Raza, Ibrahim ; Baluch, Fatima ; Raza, Ahmed ; Bani-Sadar, Ahmad ; Qureshi, Ahmad Uzair ; Adil, Muhammad ; Raza, Awais ; Javaid, Mahnoor ; Waqar, Muhammad ; Khan, Maryam Ali ; Arshad, Mohammad Mohsin ; Amjad, Mohammadasim ; Allen Ingabire, J. C. ; Mutabazi, Alphonse Zeta ; Uzabumwana, Norbert ; Duhoranenayo, Dieudonne ; Clegg-Lamptey, Joe Nat ; Imoro, Osman ; Abem, Owusu Emmanuel ; Wondoh, Paul ; Sale, Danjuma ; Abdullahi, Lawal ; Osagie, Olabisi ; Faboya, Omolara ; Fatuga, Adedeji ; Taiwo, Agboola ; Nwabuoku, Emeka ; Khan, Zain Ali ; Rickard, Jennifer ; Tan, Choy Ling ; Siaw, Jia Yng ; Yam, Sir Young ; Wilson, Ling ; Aziz, Mohamed Rezal Abdul. / Management and Outcomes Following Surgery for Gastrointestinal Typhoid : An International, Prospective, Multicentre Cohort Study. In: World Journal of Surgery. 2018 ; pp. 1-10.
@article{430cd665d3d848a0a7325f87cf1becdb,
title = "Management and Outcomes Following Surgery for Gastrointestinal Typhoid: An International, Prospective, Multicentre Cohort Study",
abstract = "Background: Gastrointestinal perforation is the most serious complication of typhoid fever, with a high disease burden in low-income countries. Reliable, prospective, contemporary surgical outcome data are scarce in these settings. This study aimed to investigate surgical outcomes following surgery for intestinal typhoid. Methods: Two multicentre, international prospective cohort studies of consecutive patients undergoing surgery for gastrointestinal typhoid perforation were conducted. Outcomes were measured at 30 days and included mortality, surgical site infection, organ space infection and reintervention rate. Multilevel logistic regression models were used to adjust for clinically plausible explanatory variables. Effect estimates are expressed as odds ratios (ORs) alongside their corresponding 95{\%} confidence intervals. Results: A total of 88 patients across the GlobalSurg 1 and GlobalSurg 2 studies were included, from 11 countries. Children comprised 38.6{\%} (34/88) of included patients. Most patients (87/88) had intestinal perforation. The 30-day mortality rate was 9.1{\%} (8/88), which was higher in children (14.7 vs. 5.6{\%}). Surgical site infection was common, at 67.0{\%} (59/88). Organ site infection was common, with 10.2{\%} of patients affected. An ASA grade of III and above was a strong predictor of 30-day post-operative mortality, at the univariable level and following adjustment for explanatory variables (OR 15.82, 95{\%} CI 1.53–163.57, p = 0.021). Conclusions: With high mortality and complication rates, outcomes from surgery for intestinal typhoid remain poor. Future studies in this area should focus on sustainable interventions which can reduce perioperative morbidity. At a policy level, improving these outcomes will require both surgical and public health system advances.",
author = "{Globalsurg Collaborative}, Collaborative and Drake, {Thomas M.} and James Glasbey and Fitzgerald, {J. Edward} and Riinu Ots and Harrison, {Ewen M.} and Stephen Tabiri and Aneel Bhangu and Ademuyiwa, {Adesoji O.} and Aguilera, {Maria Lorena} and Philip Alexander and Al-Saqqa, {Sara W.} and Giuliano Borda-Luque and Ainhoa Costas-Chavarri and Drake, {Thomas M.} and Faustin Ntirenganya and Fitzgerald, {J. Edward} and Fergusson, {Stuart J.} and James Glasbey and {Allen Ingabire}, {J. C.} and Lawani Isma{\"i}l and Salem, {Hosni Khairy} and Kojo, {Anyomih Theophilus Teddy} and Lapitan, {Marie Carmela} and Richard Lilford and Mihaljevic, {Andre L.} and Dion Morton and Mutabazi, {Alphonse Zeta} and Dmitri Nepogodiev and Adisa, {Adewale O.} and Riinu Ots and Francesco Pata and Thomas Pinkney and Tomas Poškus and Qureshi, {Ahmad Uzair} and {la Medina}, {Antonio Ramos De} and Sarah Rayne and Shaw, {Catherine A.} and Sebastian Shu and Richard Spence and Neil Smart and Stephen Tabiri and Harrison, {Ewen M.} and Ademuyiwa, {A. O.} and S. Tabiri and Manipal, {Cutting Edge} and M. Mohan and J. Jeyakumar and Mitul, {Ashrarur Rahman} and Khalid Mahmud and Margub Hussain and Hafiz Hakim and Tapan Kumar and Antje Oosterkamp and Francis Abantanga and Kwaku Boakye-Yiadom and Mohammed Bukari and Frank Owusu and Joseph Awuku-Asabre and Stephen Tabiri and Bray, {Lemuel Davies} and Prasad, {S. S.} and Anand Kirishnan and Nidhi Gyanchandani and Kumar, {Bylapudi Seshu} and Muthukumaran Rangarajan and Sriram Bhat and Anjana Sreedharan and Kinnera, {S. V.} and Yella Reddy and Caranj Venugopal and Sunil Kumar and Abhishek Mittal and Shravan Nadkarni and Lakshmi, {Harish Neelamraju} and Puneet Malik and Neel Limaye and Srinivas Pai and Pratik Jain and Monty Khajanchi and Savni Satoskar and Rajeev Satoskar and Mahamood, {Abid Bin} and Ross Coomber and Kenneth Johnson and Jennifer Nowers and Aminu Mohammad and Anyanwu, {Lofty John} and Abdulrahman Sheshe and Alaba Adesina and Olubukola Faturoti and Ogechukwu Taiwo and Ibrahim, {Muhammad Habib} and Nasir, {Abdulrasheed A.} and Suleiman, {Siyaka Itopa} and Adewale Adeniyi and Opeoluwa Adesanya and Ademola Adebanjo and Omolara Williams and Kazeem Atobatele and Ayokunle Ogunyemi and Mobolaji Oludara and Olabode Oshodi and Roland Osuoji and Adesoji Ademuyiwa and Lawal, {Abdul Razzaq Oluwagbemiga} and Felix Alakaloko and Olumide Elebute and Adedapo Osinowo and Christopher Bode and Abidemi Adesuyi and Adesoji Tade and Adeleke Adekoya and Collins Nwokoro and Ayandipo, {Omobolaji O.} and Lawal, {Taiwo Akeem} and Ajao, {Akinlabi E.} and Ali, {Samuel Sani} and Babatunde Odeyemi and Samson Olori and Ademola Popoola and Ademola Adeyeye and James Adeniran and Bhopal, {Kamran Faisal} and Zainab Iftikhar and Furqan, {Muhammad Mohsin} and Bakhtiar Nighat and Masood Jawaid and Abdul Khalique and Ahsan Zil-E-Ali and Anam Rashid and Dharamshi, {Hasnain Abbas} and Tahira Naqvi and Ahmad Faraz and Anwar, {Abdul Wahid} and Yaseen, {Tahir Muhammad} and Shamsi, {Ghina Shamim} and Ghina Shamsi and Tahir Yaseen and Wahid Anwer and Arachchi, {Prasad Pitigala} and Senanayake, {Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha} and Arachchige, {Lalith Asanka Jayasooriya Jayasooriya} and Sivasuriya Sivaganesh and Samaraweera, {Dulan Irusha} and Vimalakanthan Thanusan and Lawani Isma{\"i}l and Stephen Tabiri and Tew, {Yong Yong} and Ademuyiwa, {Adesoji O.} and Tanzeela Gala and Fernande Djivoh and Lawani Isma{\"i}l and Francis Dossou and Seto, {Djifid Morel} and Gbessi, {Dansou Gaspard} and Bruno Noukpozounkou and Souaibou, {Yacoubou Imorou} and Keke, {Kp{\`e}mahouton Ren{\'e}} and Fred Hodonou and Ahounou, {Ernest Yemalin Stephane} and Thierry Alihonou and Max D{\'e}nakpo and Germain Ahlonsou and Stephen Tabiri and Kojo, {Anyomih Theophilus Teddy} and Dickson Bandoh and Francis Abantanga and Martin Kyereh and Hamza Asumah and Appiah, {Eric Kofi} and Paul Wondoh and Adam Gyedu and Charles Dally and Kwabena Agbedinu and Michael Amoah and Abiboye Yifieyeh and Frank Owusu and Mabel Amoako-Boateng and Makafui Dayie and Richmond Hagan and Sam Debrah and Micheal Ohene-Yeboah and Clegg-Lampety, {Joe Nat} and Victor Etwire and Jonathan Dakubo and Samuel Essoun and William Bonney and Hope Glover-Addy and Samuel Osei-Nketiah and Joachim Amoako and Niiarmah Adu-Aryee and William Appeadu-Mensah and Antoinette Bediako-Bowan and Florence Dedey and Mattew Ekow and Emmanuel Akatibo and Musah Yakubu and Kordorwu, {Hope Edem Kofi} and Kwasi Asare-Bediako and Enoch Tackie and Kenneth Aaniana and Emmanuel Acquah and Richard Opoku-Agyeman and Anthony Avoka and Kwasi Kusi and Kwame Maison and Gyamfi, {Frank Enoch} and Barnabas, {Gandau Naa} and Saiba Abdul-Latif and Amoako, {Philip Taah} and Anthony Davor and Victor Dassah and Enoch Dagoe and Prince Kwakyeafriyie and Elliot Akoto and Eric Ackom and Ekow Mensah and Atkins, {Ebenezer Takyi} and Coompson, {Christian Lari} and Taha Yusufali and Hussein Mohammed and Justus Lando and Robert Parker and Wairimu Ndegwa and Chai, {Feng Yih} and Asilah, {Siti Mohd Desa} and Syibrah, {Khuzaimah Zahid} and Chin, {Pui Xin} and Afizah Salleh and Riswan, {Nur Zulaika} and Roslani, {April Camilla} and Chong, {Hoong Yin} and Aziz, {Nora Abdul} and Poh, {Keat Seong} and Chai, {Chu Ann} and Sandip Kumar and Taher, {Mustafa Mohammed} and Kosai, {Nik Ritza} and Aziz, {Dayang Nita Abdul} and Reynu Rajan and Rokayah Julaihi and Jethwani, {Durvesh Lacthman} and Yahaya, {Muhammad Taqiyuddin} and Abdullah, {Nik Azim Nik} and Mathew, {Susan Wndy} and Chung, {Kuet Jun} and Nirumal, {Milaksh Kumar} and {Goh Ern Tze}, R. and Ali, {Syed Abdul Wahhab Eusoffee Wan} and Gan, {Yiing Yee} and Ting, {Jesse Ron Swire} and Sii, {Samuel S.Y.} and Koay, {Kean Leong} and Tan, {Yi Koon} and Cheah, {Alvin Ee Zhiun} and Wong, {Chui Yee} and Mat, {Tuan Nur’Azmah Tuan} and Chow, {Crystal Yern Nee} and Har, {Prisca A.L.} and Yishan Der and Tew, {Yong Yong} and Fitjerald Henry and Xinwei Low and Neo, {Ya Theng} and Heng, {Hian Ee} and Kong, {Shu Ning} and Cheewei Gan and Mok, {Yi Ting} and Tan, {Yee Wen} and Kandasami Palayan and Tata, {Mahadevan Deva} and Cheong, {Yih Jeng} and Kuhaendran Gunaseelan and Nasir, {Wan Nurul ‘Ain Wan Mohd} and Pigeneswaren Yoganathan and Lee, {Eu Xian} and Saw, {Jian Er} and Yeang, {Li Jing} and Koh, {Pei Ying} and Lim, {Shyang Yee} and Teo, {Shuang Yi} and Akinlabi Ajao and Omobolaji Ayandipo and Taiwo Lawal and Abdussemiu Abdurrazzaaq and Muslimat Alada and Abdulrasheed Nasir and James Adeniran and Olufemi Habeeb and Ademola Popoola and Ademola Adeyeye and Ademola Adebanjo and Opeoluwa Adesanya and Adewale Adeniyi and Henry Mendel and Bashir Bello and Umar Muktar and Adedapo Osinowo and Olajide, {Thomas Olagboyega} and Oyindamola Oshati and George Ihediwa and Babajide Adenekan and Victor Nwinee and Felix Alakaloko and Adesoji Ademuyiwa and Olumide Elebute and Abdulrazzaq Lawal and Chris Bode and Mojolaoluwa Olugbemi and Alaba Adesina and Olubukola Faturoti and Oluwatomi Odutola and Oluwaseyi Adebola and Clement Onuoha and Ogechukwu Taiwo and Omolara Williams and Fatai Balogun and Olalekan Ajai and Mobolaji Oludara and Iloba Njokanma and Roland Osuoji and Stephen Kache and Jonathan Ajah and Jerry Makama and Ahmed Adamu and Suleiman Baba and Mohammad Aliyu and Shamsudeen Aliyu and Yahaya Ukwenya and Halima Aliyu and Tunde Sholadoye and Muhammad Daniyan and Oluseyi Ogunsua and Anyanwu, {Lofty John} and Abdurrahaman Sheshe and Aminu Mohammad and Samson Olori and Philip Mshelbwala and Babatunde Odeyemi and Garba Samson and Timothy, {Oyediran Kehinde} and Samuel, {Sani Ali} and Anthony Ajiboye and Ademola Adeyeye and Isaac Amole and Olajide Abiola and Akin Olaolorun and Najwa Nadeem and Muhammad Saqlain and Jibran Abbasy and Alvi, {Abdul Rehman} and Tanzeela Gala and Noman Shahzad and Bhopal, {Kamran Faisal} and Zainab Iftikhar and Butt, {Muhammad Talha} and Razi, {Syed Asaat Ul} and Asdaq Ahmed and Niazi, {Ali Khan} and Ibrahim Raza and Fatima Baluch and Ahmed Raza and Ahmad Bani-Sadar and Qureshi, {Ahmad Uzair} and Muhammad Adil and Awais Raza and Mahnoor Javaid and Muhammad Waqar and Khan, {Maryam Ali} and Arshad, {Mohammad Mohsin} and Mohammadasim Amjad and {Allen Ingabire}, {J. C.} and Mutabazi, {Alphonse Zeta} and Norbert Uzabumwana and Dieudonne Duhoranenayo and Clegg-Lamptey, {Joe Nat} and Osman Imoro and Abem, {Owusu Emmanuel} and Paul Wondoh and Danjuma Sale and Lawal Abdullahi and Olabisi Osagie and Omolara Faboya and Adedeji Fatuga and Agboola Taiwo and Emeka Nwabuoku and Khan, {Zain Ali} and Jennifer Rickard and Tan, {Choy Ling} and Siaw, {Jia Yng} and Yam, {Sir Young} and Ling Wilson and Aziz, {Mohamed Rezal Abdul}",
year = "2018",
month = "5",
day = "3",
doi = "10.1007/s00268-018-4624-8",
language = "English",
pages = "1--10",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York",

}

TY - JOUR

T1 - Management and Outcomes Following Surgery for Gastrointestinal Typhoid

T2 - An International, Prospective, Multicentre Cohort Study

AU - Globalsurg Collaborative, Collaborative

AU - Drake, Thomas M.

AU - Glasbey, James

AU - Fitzgerald, J. Edward

AU - Ots, Riinu

AU - Harrison, Ewen M.

AU - Tabiri, Stephen

AU - Bhangu, Aneel

AU - Ademuyiwa, Adesoji O.

AU - Aguilera, Maria Lorena

AU - Alexander, Philip

AU - Al-Saqqa, Sara W.

AU - Borda-Luque, Giuliano

AU - Costas-Chavarri, Ainhoa

AU - Drake, Thomas M.

AU - Ntirenganya, Faustin

AU - Fitzgerald, J. Edward

AU - Fergusson, Stuart J.

AU - Glasbey, James

AU - Allen Ingabire, J. C.

AU - Ismaïl, Lawani

AU - Salem, Hosni Khairy

AU - Kojo, Anyomih Theophilus Teddy

AU - Lapitan, Marie Carmela

AU - Lilford, Richard

AU - Mihaljevic, Andre L.

AU - Morton, Dion

AU - Mutabazi, Alphonse Zeta

AU - Nepogodiev, Dmitri

AU - Adisa, Adewale O.

AU - Ots, Riinu

AU - Pata, Francesco

AU - Pinkney, Thomas

AU - Poškus, Tomas

AU - Qureshi, Ahmad Uzair

AU - la Medina, Antonio Ramos De

AU - Rayne, Sarah

AU - Shaw, Catherine A.

AU - Shu, Sebastian

AU - Spence, Richard

AU - Smart, Neil

AU - Tabiri, Stephen

AU - Harrison, Ewen M.

AU - Ademuyiwa, A. O.

AU - Tabiri, S.

AU - Manipal, Cutting Edge

AU - Mohan, M.

AU - Jeyakumar, J.

AU - Mitul, Ashrarur Rahman

AU - Mahmud, Khalid

AU - Hussain, Margub

AU - Hakim, Hafiz

AU - Kumar, Tapan

AU - Oosterkamp, Antje

AU - Abantanga, Francis

AU - Boakye-Yiadom, Kwaku

AU - Bukari, Mohammed

AU - Owusu, Frank

AU - Awuku-Asabre, Joseph

AU - Tabiri, Stephen

AU - Bray, Lemuel Davies

AU - Prasad, S. S.

AU - Kirishnan, Anand

AU - Gyanchandani, Nidhi

AU - Kumar, Bylapudi Seshu

AU - Rangarajan, Muthukumaran

AU - Bhat, Sriram

AU - Sreedharan, Anjana

AU - Kinnera, S. V.

AU - Reddy, Yella

AU - Venugopal, Caranj

AU - Kumar, Sunil

AU - Mittal, Abhishek

AU - Nadkarni, Shravan

AU - Lakshmi, Harish Neelamraju

AU - Malik, Puneet

AU - Limaye, Neel

AU - Pai, Srinivas

AU - Jain, Pratik

AU - Khajanchi, Monty

AU - Satoskar, Savni

AU - Satoskar, Rajeev

AU - Mahamood, Abid Bin

AU - Coomber, Ross

AU - Johnson, Kenneth

AU - Nowers, Jennifer

AU - Mohammad, Aminu

AU - Anyanwu, Lofty John

AU - Sheshe, Abdulrahman

AU - Adesina, Alaba

AU - Faturoti, Olubukola

AU - Taiwo, Ogechukwu

AU - Ibrahim, Muhammad Habib

AU - Nasir, Abdulrasheed A.

AU - Suleiman, Siyaka Itopa

AU - Adeniyi, Adewale

AU - Adesanya, Opeoluwa

AU - Adebanjo, Ademola

AU - Williams, Omolara

AU - Atobatele, Kazeem

AU - Ogunyemi, Ayokunle

AU - Oludara, Mobolaji

AU - Oshodi, Olabode

AU - Osuoji, Roland

AU - Ademuyiwa, Adesoji

AU - Lawal, Abdul Razzaq Oluwagbemiga

AU - Alakaloko, Felix

AU - Elebute, Olumide

AU - Osinowo, Adedapo

AU - Bode, Christopher

AU - Adesuyi, Abidemi

AU - Tade, Adesoji

AU - Adekoya, Adeleke

AU - Nwokoro, Collins

AU - Ayandipo, Omobolaji O.

AU - Lawal, Taiwo Akeem

AU - Ajao, Akinlabi E.

AU - Ali, Samuel Sani

AU - Odeyemi, Babatunde

AU - Olori, Samson

AU - Popoola, Ademola

AU - Adeyeye, Ademola

AU - Adeniran, James

AU - Bhopal, Kamran Faisal

AU - Iftikhar, Zainab

AU - Furqan, Muhammad Mohsin

AU - Nighat, Bakhtiar

AU - Jawaid, Masood

AU - Khalique, Abdul

AU - Zil-E-Ali, Ahsan

AU - Rashid, Anam

AU - Dharamshi, Hasnain Abbas

AU - Naqvi, Tahira

AU - Faraz, Ahmad

AU - Anwar, Abdul Wahid

AU - Yaseen, Tahir Muhammad

AU - Shamsi, Ghina Shamim

AU - Shamsi, Ghina

AU - Yaseen, Tahir

AU - Anwer, Wahid

AU - Arachchi, Prasad Pitigala

AU - Senanayake, Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha

AU - Arachchige, Lalith Asanka Jayasooriya Jayasooriya

AU - Sivaganesh, Sivasuriya

AU - Samaraweera, Dulan Irusha

AU - Thanusan, Vimalakanthan

AU - Ismaïl, Lawani

AU - Tabiri, Stephen

AU - Tew, Yong Yong

AU - Ademuyiwa, Adesoji O.

AU - Gala, Tanzeela

AU - Djivoh, Fernande

AU - Ismaïl, Lawani

AU - Dossou, Francis

AU - Seto, Djifid Morel

AU - Gbessi, Dansou Gaspard

AU - Noukpozounkou, Bruno

AU - Souaibou, Yacoubou Imorou

AU - Keke, Kpèmahouton René

AU - Hodonou, Fred

AU - Ahounou, Ernest Yemalin Stephane

AU - Alihonou, Thierry

AU - Dénakpo, Max

AU - Ahlonsou, Germain

AU - Tabiri, Stephen

AU - Kojo, Anyomih Theophilus Teddy

AU - Bandoh, Dickson

AU - Abantanga, Francis

AU - Kyereh, Martin

AU - Asumah, Hamza

AU - Appiah, Eric Kofi

AU - Wondoh, Paul

AU - Gyedu, Adam

AU - Dally, Charles

AU - Agbedinu, Kwabena

AU - Amoah, Michael

AU - Yifieyeh, Abiboye

AU - Owusu, Frank

AU - Amoako-Boateng, Mabel

AU - Dayie, Makafui

AU - Hagan, Richmond

AU - Debrah, Sam

AU - Ohene-Yeboah, Micheal

AU - Clegg-Lampety, Joe Nat

AU - Etwire, Victor

AU - Dakubo, Jonathan

AU - Essoun, Samuel

AU - Bonney, William

AU - Glover-Addy, Hope

AU - Osei-Nketiah, Samuel

AU - Amoako, Joachim

AU - Adu-Aryee, Niiarmah

AU - Appeadu-Mensah, William

AU - Bediako-Bowan, Antoinette

AU - Dedey, Florence

AU - Ekow, Mattew

AU - Akatibo, Emmanuel

AU - Yakubu, Musah

AU - Kordorwu, Hope Edem Kofi

AU - Asare-Bediako, Kwasi

AU - Tackie, Enoch

AU - Aaniana, Kenneth

AU - Acquah, Emmanuel

AU - Opoku-Agyeman, Richard

AU - Avoka, Anthony

AU - Kusi, Kwasi

AU - Maison, Kwame

AU - Gyamfi, Frank Enoch

AU - Barnabas, Gandau Naa

AU - Abdul-Latif, Saiba

AU - Amoako, Philip Taah

AU - Davor, Anthony

AU - Dassah, Victor

AU - Dagoe, Enoch

AU - Kwakyeafriyie, Prince

AU - Akoto, Elliot

AU - Ackom, Eric

AU - Mensah, Ekow

AU - Atkins, Ebenezer Takyi

AU - Coompson, Christian Lari

AU - Yusufali, Taha

AU - Mohammed, Hussein

AU - Lando, Justus

AU - Parker, Robert

AU - Ndegwa, Wairimu

AU - Chai, Feng Yih

AU - Asilah, Siti Mohd Desa

AU - Syibrah, Khuzaimah Zahid

AU - Chin, Pui Xin

AU - Salleh, Afizah

AU - Riswan, Nur Zulaika

AU - Roslani, April Camilla

AU - Chong, Hoong Yin

AU - Aziz, Nora Abdul

AU - Poh, Keat Seong

AU - Chai, Chu Ann

AU - Kumar, Sandip

AU - Taher, Mustafa Mohammed

AU - Kosai, Nik Ritza

AU - Aziz, Dayang Nita Abdul

AU - Rajan, Reynu

AU - Julaihi, Rokayah

AU - Jethwani, Durvesh Lacthman

AU - Yahaya, Muhammad Taqiyuddin

AU - Abdullah, Nik Azim Nik

AU - Mathew, Susan Wndy

AU - Chung, Kuet Jun

AU - Nirumal, Milaksh Kumar

AU - Goh Ern Tze, R.

AU - Ali, Syed Abdul Wahhab Eusoffee Wan

AU - Gan, Yiing Yee

AU - Ting, Jesse Ron Swire

AU - Sii, Samuel S.Y.

AU - Koay, Kean Leong

AU - Tan, Yi Koon

AU - Cheah, Alvin Ee Zhiun

AU - Wong, Chui Yee

AU - Mat, Tuan Nur’Azmah Tuan

AU - Chow, Crystal Yern Nee

AU - Har, Prisca A.L.

AU - Der, Yishan

AU - Tew, Yong Yong

AU - Henry, Fitjerald

AU - Low, Xinwei

AU - Neo, Ya Theng

AU - Heng, Hian Ee

AU - Kong, Shu Ning

AU - Gan, Cheewei

AU - Mok, Yi Ting

AU - Tan, Yee Wen

AU - Palayan, Kandasami

AU - Tata, Mahadevan Deva

AU - Cheong, Yih Jeng

AU - Gunaseelan, Kuhaendran

AU - Nasir, Wan Nurul ‘Ain Wan Mohd

AU - Yoganathan, Pigeneswaren

AU - Lee, Eu Xian

AU - Saw, Jian Er

AU - Yeang, Li Jing

AU - Koh, Pei Ying

AU - Lim, Shyang Yee

AU - Teo, Shuang Yi

AU - Ajao, Akinlabi

AU - Ayandipo, Omobolaji

AU - Lawal, Taiwo

AU - Abdurrazzaaq, Abdussemiu

AU - Alada, Muslimat

AU - Nasir, Abdulrasheed

AU - Adeniran, James

AU - Habeeb, Olufemi

AU - Popoola, Ademola

AU - Adeyeye, Ademola

AU - Adebanjo, Ademola

AU - Adesanya, Opeoluwa

AU - Adeniyi, Adewale

AU - Mendel, Henry

AU - Bello, Bashir

AU - Muktar, Umar

AU - Osinowo, Adedapo

AU - Olajide, Thomas Olagboyega

AU - Oshati, Oyindamola

AU - Ihediwa, George

AU - Adenekan, Babajide

AU - Nwinee, Victor

AU - Alakaloko, Felix

AU - Ademuyiwa, Adesoji

AU - Elebute, Olumide

AU - Lawal, Abdulrazzaq

AU - Bode, Chris

AU - Olugbemi, Mojolaoluwa

AU - Adesina, Alaba

AU - Faturoti, Olubukola

AU - Odutola, Oluwatomi

AU - Adebola, Oluwaseyi

AU - Onuoha, Clement

AU - Taiwo, Ogechukwu

AU - Williams, Omolara

AU - Balogun, Fatai

AU - Ajai, Olalekan

AU - Oludara, Mobolaji

AU - Njokanma, Iloba

AU - Osuoji, Roland

AU - Kache, Stephen

AU - Ajah, Jonathan

AU - Makama, Jerry

AU - Adamu, Ahmed

AU - Baba, Suleiman

AU - Aliyu, Mohammad

AU - Aliyu, Shamsudeen

AU - Ukwenya, Yahaya

AU - Aliyu, Halima

AU - Sholadoye, Tunde

AU - Daniyan, Muhammad

AU - Ogunsua, Oluseyi

AU - Anyanwu, Lofty John

AU - Sheshe, Abdurrahaman

AU - Mohammad, Aminu

AU - Olori, Samson

AU - Mshelbwala, Philip

AU - Odeyemi, Babatunde

AU - Samson, Garba

AU - Timothy, Oyediran Kehinde

AU - Samuel, Sani Ali

AU - Ajiboye, Anthony

AU - Adeyeye, Ademola

AU - Amole, Isaac

AU - Abiola, Olajide

AU - Olaolorun, Akin

AU - Nadeem, Najwa

AU - Saqlain, Muhammad

AU - Abbasy, Jibran

AU - Alvi, Abdul Rehman

AU - Gala, Tanzeela

AU - Shahzad, Noman

AU - Bhopal, Kamran Faisal

AU - Iftikhar, Zainab

AU - Butt, Muhammad Talha

AU - Razi, Syed Asaat Ul

AU - Ahmed, Asdaq

AU - Niazi, Ali Khan

AU - Raza, Ibrahim

AU - Baluch, Fatima

AU - Raza, Ahmed

AU - Bani-Sadar, Ahmad

AU - Qureshi, Ahmad Uzair

AU - Adil, Muhammad

AU - Raza, Awais

AU - Javaid, Mahnoor

AU - Waqar, Muhammad

AU - Khan, Maryam Ali

AU - Arshad, Mohammad Mohsin

AU - Amjad, Mohammadasim

AU - Allen Ingabire, J. C.

AU - Mutabazi, Alphonse Zeta

AU - Uzabumwana, Norbert

AU - Duhoranenayo, Dieudonne

AU - Clegg-Lamptey, Joe Nat

AU - Imoro, Osman

AU - Abem, Owusu Emmanuel

AU - Wondoh, Paul

AU - Sale, Danjuma

AU - Abdullahi, Lawal

AU - Osagie, Olabisi

AU - Faboya, Omolara

AU - Fatuga, Adedeji

AU - Taiwo, Agboola

AU - Nwabuoku, Emeka

AU - Khan, Zain Ali

AU - Rickard, Jennifer

AU - Tan, Choy Ling

AU - Siaw, Jia Yng

AU - Yam, Sir Young

AU - Wilson, Ling

AU - Aziz, Mohamed Rezal Abdul

PY - 2018/5/3

Y1 - 2018/5/3

N2 - Background: Gastrointestinal perforation is the most serious complication of typhoid fever, with a high disease burden in low-income countries. Reliable, prospective, contemporary surgical outcome data are scarce in these settings. This study aimed to investigate surgical outcomes following surgery for intestinal typhoid. Methods: Two multicentre, international prospective cohort studies of consecutive patients undergoing surgery for gastrointestinal typhoid perforation were conducted. Outcomes were measured at 30 days and included mortality, surgical site infection, organ space infection and reintervention rate. Multilevel logistic regression models were used to adjust for clinically plausible explanatory variables. Effect estimates are expressed as odds ratios (ORs) alongside their corresponding 95% confidence intervals. Results: A total of 88 patients across the GlobalSurg 1 and GlobalSurg 2 studies were included, from 11 countries. Children comprised 38.6% (34/88) of included patients. Most patients (87/88) had intestinal perforation. The 30-day mortality rate was 9.1% (8/88), which was higher in children (14.7 vs. 5.6%). Surgical site infection was common, at 67.0% (59/88). Organ site infection was common, with 10.2% of patients affected. An ASA grade of III and above was a strong predictor of 30-day post-operative mortality, at the univariable level and following adjustment for explanatory variables (OR 15.82, 95% CI 1.53–163.57, p = 0.021). Conclusions: With high mortality and complication rates, outcomes from surgery for intestinal typhoid remain poor. Future studies in this area should focus on sustainable interventions which can reduce perioperative morbidity. At a policy level, improving these outcomes will require both surgical and public health system advances.

AB - Background: Gastrointestinal perforation is the most serious complication of typhoid fever, with a high disease burden in low-income countries. Reliable, prospective, contemporary surgical outcome data are scarce in these settings. This study aimed to investigate surgical outcomes following surgery for intestinal typhoid. Methods: Two multicentre, international prospective cohort studies of consecutive patients undergoing surgery for gastrointestinal typhoid perforation were conducted. Outcomes were measured at 30 days and included mortality, surgical site infection, organ space infection and reintervention rate. Multilevel logistic regression models were used to adjust for clinically plausible explanatory variables. Effect estimates are expressed as odds ratios (ORs) alongside their corresponding 95% confidence intervals. Results: A total of 88 patients across the GlobalSurg 1 and GlobalSurg 2 studies were included, from 11 countries. Children comprised 38.6% (34/88) of included patients. Most patients (87/88) had intestinal perforation. The 30-day mortality rate was 9.1% (8/88), which was higher in children (14.7 vs. 5.6%). Surgical site infection was common, at 67.0% (59/88). Organ site infection was common, with 10.2% of patients affected. An ASA grade of III and above was a strong predictor of 30-day post-operative mortality, at the univariable level and following adjustment for explanatory variables (OR 15.82, 95% CI 1.53–163.57, p = 0.021). Conclusions: With high mortality and complication rates, outcomes from surgery for intestinal typhoid remain poor. Future studies in this area should focus on sustainable interventions which can reduce perioperative morbidity. At a policy level, improving these outcomes will require both surgical and public health system advances.

UR - http://www.scopus.com/inward/record.url?scp=85046421984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046421984&partnerID=8YFLogxK

U2 - 10.1007/s00268-018-4624-8

DO - 10.1007/s00268-018-4624-8

M3 - Article

C2 - 29725797

AN - SCOPUS:85046421984

SP - 1

EP - 10

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

ER -