Malignant melanoma of the gastrointestinal tract presenting as a bleeding gastric ulcer.

Noraidah Masir, A. Y. Jasmi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Malignant melanoma involving the gastrointestinal tract is diagnosed antemortem in only a small percentage of patients with the disease. Presenting symptoms are often non-specific, causing a diagnostic problem. The vast majority of such melanomas are metastatic from a cutaneous primary, however there is evidence that the tumour can arise de novo in the gastrointestinal system. We report a 74-year-old man with malignant melanoma with an unusual presentation simulating a symptomatic gastric ulcer. He presented with epigastric pain, haematemesis and melaena. Explorative laparotomy revealed a large ulcerated tumour with several pigmented satellite nodules in the proximal stomach, multiple ileal nodules and widespread nodal and liver metastases. Proximal gastrectomy and limited small bowel resection was performed. Histology revealed the tumour to be composed of nests of epithelioid cells with melanin pigment. The tumour cells showed immunohistochemical positivity for S100 protein and HMB45 antibodies. This report emphasizes that melanoma should be a diagnostic consideration in patients with gastric ulcer.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalThe Malaysian journal of pathology
Volume25
Issue number1
Publication statusPublished - 2003

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Stomach Ulcer
Gastrointestinal Tract
Melanoma
Hemorrhage
Neoplasms
Melena
Hematemesis
Epithelioid Cells
S100 Proteins
Melanins
Gastrectomy
Laparotomy
Stomach
Histology
Neoplasm Metastasis
Pain
Skin
Antibodies
Liver

Cite this

Malignant melanoma of the gastrointestinal tract presenting as a bleeding gastric ulcer. / Masir, Noraidah; Jasmi, A. Y.

In: The Malaysian journal of pathology, Vol. 25, No. 1, 2003, p. 57-61.

Research output: Contribution to journalArticle

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