Malignant hyperthermia in a cleft lip and palate patient: A case report

Research output: Contribution to journalArticle

Abstract

Malignant hyperthermia (MH) is a rare genetic disorder that develops following exposure to volatile anaesthetic agents and depolarizing muscle relaxants. In this case report, a 10-year-old boy with cleft lip and palate underwent alveolar bone grafting for right cleft alveolus. In this surgery, the MH episode occurred approximately 2 h following induction of anaesthesia when the patient was noted to develop hypercapnia, tachycardia and hyperthermia. An MH crisis was declared. Immediate management included active cooling and intravenous dantrolene, to which the patient responded. In conclusion, early diagnosis and prompt action are very important in the successful management of MH.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalJournal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume27
Issue number4
DOIs
Publication statusPublished - 1 Jul 2015

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Malignant Hyperthermia
Cleft Lip
Cleft Palate
Neuromuscular Depolarizing Agents
Alveolar Bone Grafting
Dantrolene
Inborn Genetic Diseases
Hypercapnia
Tachycardia
Anesthetics
Early Diagnosis
Fever
Anesthesia

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pathology and Forensic Medicine
  • Surgery
  • Oral Surgery

Cite this

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title = "Malignant hyperthermia in a cleft lip and palate patient: A case report",
abstract = "Malignant hyperthermia (MH) is a rare genetic disorder that develops following exposure to volatile anaesthetic agents and depolarizing muscle relaxants. In this case report, a 10-year-old boy with cleft lip and palate underwent alveolar bone grafting for right cleft alveolus. In this surgery, the MH episode occurred approximately 2 h following induction of anaesthesia when the patient was noted to develop hypercapnia, tachycardia and hyperthermia. An MH crisis was declared. Immediate management included active cooling and intravenous dantrolene, to which the patient responded. In conclusion, early diagnosis and prompt action are very important in the successful management of MH.",
author = "S. Ramasamy and Lee, {Choon Yee} and {Syed Omar}, {Syed Nabil} and {Abd Jabar}, {Mohd Nazimi} and Rifqah Nordin and Roszalina Ramli",
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T1 - Malignant hyperthermia in a cleft lip and palate patient

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AU - Ramasamy, S.

AU - Lee, Choon Yee

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AU - Abd Jabar, Mohd Nazimi

AU - Nordin, Rifqah

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AB - Malignant hyperthermia (MH) is a rare genetic disorder that develops following exposure to volatile anaesthetic agents and depolarizing muscle relaxants. In this case report, a 10-year-old boy with cleft lip and palate underwent alveolar bone grafting for right cleft alveolus. In this surgery, the MH episode occurred approximately 2 h following induction of anaesthesia when the patient was noted to develop hypercapnia, tachycardia and hyperthermia. An MH crisis was declared. Immediate management included active cooling and intravenous dantrolene, to which the patient responded. In conclusion, early diagnosis and prompt action are very important in the successful management of MH.

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