Macular thickness as determined by optical coherence tomography in relation to degree of myopia, axial length and vitreous chamber depth in Malay subjects

Shah Farez Othman, Sharanjeet Kaur Malkeet Singh, Faudziah Abd Manan, Ahmad Iskandar Zulkarnain, Zainal Mohamad, Azrin E. Ariffin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: This study aimed to determine the relationship between macular thickness and spherical equivalent refraction (SER), axial length (AL) and vitreous chamber depth (VCD) in Malay subjects. Methods: Sixty-three subjects (aged 19-24years) with a mean SER of -1.79 ± 2.24D, mean axial length of 24.26 ± 1.35mm and mean vitreous chamber depth of 17.02 ± 1.33mm were included in this clinical cross-sectional study. Stratus optical coherence tomography (Time Domain optical coherence tomography) was used to determine the thickness of the outer macular (perifovea) and inner macular (parafovea) at four different locations, that is, temporal, superior, nasal and inferior quadrants and also the fovea itself. Results: Positive correlations were found between the outer macular (perifovea) thickness and SER at the temporal (R = 0.47, p < 0.05), superior (R = 0.36, p < 0.05) and inferior (R = 0.31, p < 0.05) quadrants. Foveal thickness was also positively correlated with AL (R = 0.34, p < 0.05) and VCD (R = 0.32, p < 0.05). Negative correlations were found between outer macular thickness and axial length at the temporal (R = -0.46, p < 0.05), superior (R = -0.27, p < 0.05), nasal (R = -0.25, p < 0.05) and inferior (R = -0.36, p < 0.05) quadrants. Negative correlations were also found between outer macular thickness and VCD at the temporal (R = -0.51, p < 0.05), superior (R = -0.32, p < 0.05), nasal (R = -0.31, p < 0.05) and inferior (R = -0.40, p < 0.05) quadrants. Conclusions: This study shows that the degree of myopia and elongation of the globe are associated with thinning of most areas of the perifovea. A trend for foveal thickening in the high myopia group is also inferred, although this does not apply to the low and moderate myopia groups.

Original languageEnglish
Pages (from-to)484-491
Number of pages8
JournalClinical and Experimental Optometry
Volume95
Issue number5
DOIs
Publication statusPublished - Sep 2012

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Myopia
Optical Coherence Tomography
Nose
Cross-Sectional Studies

Keywords

  • Axial length
  • Macular
  • Myopia
  • Optical coherence tomography
  • Refraction
  • Vitreous chamber depth

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Macular thickness as determined by optical coherence tomography in relation to degree of myopia, axial length and vitreous chamber depth in Malay subjects. / Othman, Shah Farez; Malkeet Singh, Sharanjeet Kaur; Manan, Faudziah Abd; Zulkarnain, Ahmad Iskandar; Mohamad, Zainal; Ariffin, Azrin E.

In: Clinical and Experimental Optometry, Vol. 95, No. 5, 09.2012, p. 484-491.

Research output: Contribution to journalArticle

Othman, Shah Farez ; Malkeet Singh, Sharanjeet Kaur ; Manan, Faudziah Abd ; Zulkarnain, Ahmad Iskandar ; Mohamad, Zainal ; Ariffin, Azrin E. / Macular thickness as determined by optical coherence tomography in relation to degree of myopia, axial length and vitreous chamber depth in Malay subjects. In: Clinical and Experimental Optometry. 2012 ; Vol. 95, No. 5. pp. 484-491.
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AU - Malkeet Singh, Sharanjeet Kaur

AU - Manan, Faudziah Abd

AU - Zulkarnain, Ahmad Iskandar

AU - Mohamad, Zainal

AU - Ariffin, Azrin E.

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N2 - Purpose: This study aimed to determine the relationship between macular thickness and spherical equivalent refraction (SER), axial length (AL) and vitreous chamber depth (VCD) in Malay subjects. Methods: Sixty-three subjects (aged 19-24years) with a mean SER of -1.79 ± 2.24D, mean axial length of 24.26 ± 1.35mm and mean vitreous chamber depth of 17.02 ± 1.33mm were included in this clinical cross-sectional study. Stratus optical coherence tomography (Time Domain optical coherence tomography) was used to determine the thickness of the outer macular (perifovea) and inner macular (parafovea) at four different locations, that is, temporal, superior, nasal and inferior quadrants and also the fovea itself. Results: Positive correlations were found between the outer macular (perifovea) thickness and SER at the temporal (R = 0.47, p < 0.05), superior (R = 0.36, p < 0.05) and inferior (R = 0.31, p < 0.05) quadrants. Foveal thickness was also positively correlated with AL (R = 0.34, p < 0.05) and VCD (R = 0.32, p < 0.05). Negative correlations were found between outer macular thickness and axial length at the temporal (R = -0.46, p < 0.05), superior (R = -0.27, p < 0.05), nasal (R = -0.25, p < 0.05) and inferior (R = -0.36, p < 0.05) quadrants. Negative correlations were also found between outer macular thickness and VCD at the temporal (R = -0.51, p < 0.05), superior (R = -0.32, p < 0.05), nasal (R = -0.31, p < 0.05) and inferior (R = -0.40, p < 0.05) quadrants. Conclusions: This study shows that the degree of myopia and elongation of the globe are associated with thinning of most areas of the perifovea. A trend for foveal thickening in the high myopia group is also inferred, although this does not apply to the low and moderate myopia groups.

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