Macro coumarins as novel antioxidants

Dunya L. AL-Duhaidahawi, Yasameen K. Al-Majedy, Hiba H. Ibraheem, Abdul Amir H. Kadhum, Ahmed A. Al-Amiery

Research output: Contribution to journalArticle

Abstract

The present work pointed at the design and synthesis of novel coumarin compounds as antioxidants. The alteration of 4-hydroxycoumarin by several reaction levels was performed to generate destination compounds. Spectroscopic methods like Infrared Spectra FT-IR, 1H-NMR and 13CNMR, elemental analysis techniques, melting point, and thin layer chromatography defined the structure of the prepared compounds. The antioxidant activities of individual compounds were tested against stable free radical 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH), hydrogen peroxide (H2O2) and FRAP (ferric reducing antioxidant power) and the results were related to the Gallic acid, ascorbic acid and Trolox as standards. The effects revealed that most of the syntheses presented greater activity as an antioxidant than the standards in different concentration range. The distinguished competence inactivating action was observed for compound 2 (86.3±1%) followed by compounds 3 (85±0.5%) using DPPH method. The antioxidant mode of action of the prepared compounds was also investigated.

Original languageEnglish
Pages (from-to)2562-2569
Number of pages8
JournalOriental Journal of Chemistry
Volume34
Issue number5
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Coumarins
antioxidant
Macros
Antioxidants
Thin layer chromatography
Gallic Acid
free radical
ascorbic acid
Thin Layer Chromatography
Mental Competency
hydrogen peroxide
Hydrogen Peroxide
Freezing
Ascorbic Acid
chromatography
Free Radicals
nuclear magnetic resonance
Melting point
melting
Nuclear magnetic resonance

Keywords

  • Antioxidant
  • DPPH
  • FRAP hydroxycoumarin HO in activators
  • Macromolecules.

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Drug Discovery

Cite this

AL-Duhaidahawi, D. L., Al-Majedy, Y. K., Ibraheem, H. H., Kadhum, A. A. H., & Al-Amiery, A. A. (2018). Macro coumarins as novel antioxidants. Oriental Journal of Chemistry, 34(5), 2562-2569. https://doi.org/10.13005/ojc/340544

Macro coumarins as novel antioxidants. / AL-Duhaidahawi, Dunya L.; Al-Majedy, Yasameen K.; Ibraheem, Hiba H.; Kadhum, Abdul Amir H.; Al-Amiery, Ahmed A.

In: Oriental Journal of Chemistry, Vol. 34, No. 5, 01.01.2018, p. 2562-2569.

Research output: Contribution to journalArticle

AL-Duhaidahawi, DL, Al-Majedy, YK, Ibraheem, HH, Kadhum, AAH & Al-Amiery, AA 2018, 'Macro coumarins as novel antioxidants', Oriental Journal of Chemistry, vol. 34, no. 5, pp. 2562-2569. https://doi.org/10.13005/ojc/340544
AL-Duhaidahawi DL, Al-Majedy YK, Ibraheem HH, Kadhum AAH, Al-Amiery AA. Macro coumarins as novel antioxidants. Oriental Journal of Chemistry. 2018 Jan 1;34(5):2562-2569. https://doi.org/10.13005/ojc/340544
AL-Duhaidahawi, Dunya L. ; Al-Majedy, Yasameen K. ; Ibraheem, Hiba H. ; Kadhum, Abdul Amir H. ; Al-Amiery, Ahmed A. / Macro coumarins as novel antioxidants. In: Oriental Journal of Chemistry. 2018 ; Vol. 34, No. 5. pp. 2562-2569.
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