Lymphangioma

Is intralesional bleomycin sclerotherapy effective?

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: This study aims to evaluate the effectiveness of intralesional bleomycin sclerotherapy in the treatment of lymphangioma in children and to determine the incidence of complications in the treatment. Methods: This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Results: Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed. Conclusion: Intralesional bleomycin therapy was very effective in the treatment of lymphangioma. Our results were comparable to other published studies. Bleomycin administered as intralesional injection was found to be safe as there was no serious complication or side effect observed in this study.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiomedical Imaging and Intervention Journal
Volume7
Issue number3
DOIs
Publication statusPublished - 2011

Fingerprint

Lymphangioma
Sclerotherapy
Bleomycin
Tumors
Intralesional Injections
Therapeutics
Abscess
Retrospective Studies
Injections
Incidence
Neoplasms

Keywords

  • Bleomycin
  • Lymphangioma
  • Sclerotherapy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Lymphangioma : Is intralesional bleomycin sclerotherapy effective? / Zakaria, Rozman; Thambidorai, C. R.; Abdullah Mahdy, Zaleha; Syed Zakaria, Syed Zulkifli; Zulfiqar, M. A.

In: Biomedical Imaging and Intervention Journal, Vol. 7, No. 3, 2011, p. 1-8.

Research output: Contribution to journalArticle

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N2 - Purpose: This study aims to evaluate the effectiveness of intralesional bleomycin sclerotherapy in the treatment of lymphangioma in children and to determine the incidence of complications in the treatment. Methods: This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Results: Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed. Conclusion: Intralesional bleomycin therapy was very effective in the treatment of lymphangioma. Our results were comparable to other published studies. Bleomycin administered as intralesional injection was found to be safe as there was no serious complication or side effect observed in this study.

AB - Purpose: This study aims to evaluate the effectiveness of intralesional bleomycin sclerotherapy in the treatment of lymphangioma in children and to determine the incidence of complications in the treatment. Methods: This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Results: Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed. Conclusion: Intralesional bleomycin therapy was very effective in the treatment of lymphangioma. Our results were comparable to other published studies. Bleomycin administered as intralesional injection was found to be safe as there was no serious complication or side effect observed in this study.

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