Lung cancers and the roles of natural compounds as potential chemotherapeutic and chemopreventive agents

Research output: Contribution to journalArticle

Abstract

Among all types of human cancers, lung cancer is one of the most common and has the highest mortality rate. Two major groups of lung cancer based on histological features are non-small cell lung cancers (NSCLCs) and small cell lung cancers (SCLCs). NSCLCs are further subdivided into few subtypes such as adenocarcinoma(AD), squamous cell carcinoma (SCC) and large cell carcinoma(LCC). Focusing on specific treatments or molecular targeted therapy for each type of lung cancers promising the better results as each subtype of lung cancers differ in genomic alterations, the cell of origin and growth pattern. Numerous studies have been done to search for the best chemotherapeutic and chemopreventive agents that can reduce the burden of lung cancer, primarily focusing on potential natural products. This review is focused on genomic alterations and current potential natural compounds as chemotherapeutic and chemoprevention agents specifically on each subtype of lung cancers.

Original languageEnglish
Pages (from-to)85-98
Number of pages14
JournalBiomedical and Pharmacology Journal
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Mar 2019

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Lung Neoplasms
Non-Small Cell Lung Carcinoma
Molecular Targeted Therapy
Large Cell Carcinoma
Small Cell Lung Carcinoma
Chemoprevention
Biological Products
Squamous Cell Carcinoma
Adenocarcinoma
Mortality
Growth

Keywords

  • Chemoprevention
  • Chemotherapeutic
  • Lung cancers
  • Natural compounds
  • Non-small cell lung cancers
  • Small cell lung cancer

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Among all types of human cancers, lung cancer is one of the most common and has the highest mortality rate. Two major groups of lung cancer based on histological features are non-small cell lung cancers (NSCLCs) and small cell lung cancers (SCLCs). NSCLCs are further subdivided into few subtypes such as adenocarcinoma(AD), squamous cell carcinoma (SCC) and large cell carcinoma(LCC). Focusing on specific treatments or molecular targeted therapy for each type of lung cancers promising the better results as each subtype of lung cancers differ in genomic alterations, the cell of origin and growth pattern. Numerous studies have been done to search for the best chemotherapeutic and chemopreventive agents that can reduce the burden of lung cancer, primarily focusing on potential natural products. This review is focused on genomic alterations and current potential natural compounds as chemotherapeutic and chemoprevention agents specifically on each subtype of lung cancers.",
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