LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population

Aroma A gape Gopalai, Shen Yang Lim, Jing Y i Chua, Shelisa Tey, Thien T hien Lim, Norlinah Mohamed Ibrahim, Ai H uey Tan, Gaik B ee Eow, Zariah Abdul Aziz, Santhi D atuk Puvanarajah, Shanthi Viswanathan, Irene Looi, Soo K un Lim, Li P ing Tan, Yip B oon Chong, Chong T in Tan, Yi Zhao, E. K. Tan, Azlina Ahmad-Annuar

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Abstract

The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies.

Original languageEnglish
Pages (from-to)867321
Number of pages1
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Parkinson Disease
Mutation
Population
Genes

ASJC Scopus subject areas

  • Medicine(all)

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LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population. / Gopalai, Aroma A gape; Lim, Shen Yang; Chua, Jing Y i; Tey, Shelisa; Lim, Thien T hien; Mohamed Ibrahim, Norlinah; Tan, Ai H uey; Eow, Gaik B ee; Abdul Aziz, Zariah; Puvanarajah, Santhi D atuk; Viswanathan, Shanthi; Looi, Irene; Lim, Soo K un; Tan, Li P ing; Chong, Yip B oon; Tan, Chong T in; Zhao, Yi; Tan, E. K.; Ahmad-Annuar, Azlina.

In: BioMed Research International, Vol. 2014, 2014, p. 867321.

Research output: Contribution to journalArticle

Gopalai, AAG, Lim, SY, Chua, JYI, Tey, S, Lim, TTH, Mohamed Ibrahim, N, Tan, AHU, Eow, GBE, Abdul Aziz, Z, Puvanarajah, SDA, Viswanathan, S, Looi, I, Lim, SKU, Tan, LPI, Chong, YBO, Tan, CTI, Zhao, Y, Tan, EK & Ahmad-Annuar, A 2014, 'LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population', BioMed Research International, vol. 2014, pp. 867321. https://doi.org/10.1155/2014/867321
Gopalai, Aroma A gape ; Lim, Shen Yang ; Chua, Jing Y i ; Tey, Shelisa ; Lim, Thien T hien ; Mohamed Ibrahim, Norlinah ; Tan, Ai H uey ; Eow, Gaik B ee ; Abdul Aziz, Zariah ; Puvanarajah, Santhi D atuk ; Viswanathan, Shanthi ; Looi, Irene ; Lim, Soo K un ; Tan, Li P ing ; Chong, Yip B oon ; Tan, Chong T in ; Zhao, Yi ; Tan, E. K. ; Ahmad-Annuar, Azlina. / LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population. In: BioMed Research International. 2014 ; Vol. 2014. pp. 867321.
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AU - Viswanathan, Shanthi

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AU - Lim, Soo K un

AU - Tan, Li P ing

AU - Chong, Yip B oon

AU - Tan, Chong T in

AU - Zhao, Yi

AU - Tan, E. K.

AU - Ahmad-Annuar, Azlina

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