Lowering blood pressure after acute intracerebral haemorrhage

Protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)

Tom J. Moullaali, Xia Wang, Lisa J. Woodhouse, Zhe Kang Law, Candice Delcourt, Nikola Sprigg, Kailash Krishnan, Thompson G. Robinson, Joanna M. Wardlaw, Rustam Al-Shahi Salman, Eivind Berge, Else C. Sandset, Craig S. Anderson, Philip M. Bath

Research output: Contribution to journalArticle

Abstract

Introduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH. Methods and analysis A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of Individual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient's demographic, clinical and prestroke neuroradiological characteristics. Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals. PROSPERO registration number CRD42019141136.

Original languageEnglish
Article number030121
Pages (from-to)1DUMMY
JournalBMJ Open
Volume9
Issue number7
DOIs
Publication statusPublished - 1 Jul 2019

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Cerebral Hemorrhage
Meta-Analysis
Randomized Controlled Trials
Stroke
Blood Pressure
Ethics
MEDLINE
Hypotension
Hemodynamics
Demography
Guidelines
Safety
Therapeutics

Keywords

  • blood pressure lowering
  • individual participant data meta-analysis
  • intracerebral haemorrhage
  • stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lowering blood pressure after acute intracerebral haemorrhage : Protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC). / Moullaali, Tom J.; Wang, Xia; Woodhouse, Lisa J.; Law, Zhe Kang; Delcourt, Candice; Sprigg, Nikola; Krishnan, Kailash; Robinson, Thompson G.; Wardlaw, Joanna M.; Al-Shahi Salman, Rustam; Berge, Eivind; Sandset, Else C.; Anderson, Craig S.; Bath, Philip M.

In: BMJ Open, Vol. 9, No. 7, 030121, 01.07.2019, p. 1DUMMY.

Research output: Contribution to journalArticle

Moullaali, TJ, Wang, X, Woodhouse, LJ, Law, ZK, Delcourt, C, Sprigg, N, Krishnan, K, Robinson, TG, Wardlaw, JM, Al-Shahi Salman, R, Berge, E, Sandset, EC, Anderson, CS & Bath, PM 2019, 'Lowering blood pressure after acute intracerebral haemorrhage: Protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)', BMJ Open, vol. 9, no. 7, 030121, pp. 1DUMMY. https://doi.org/10.1136/bmjopen-2019-030121
Moullaali, Tom J. ; Wang, Xia ; Woodhouse, Lisa J. ; Law, Zhe Kang ; Delcourt, Candice ; Sprigg, Nikola ; Krishnan, Kailash ; Robinson, Thompson G. ; Wardlaw, Joanna M. ; Al-Shahi Salman, Rustam ; Berge, Eivind ; Sandset, Else C. ; Anderson, Craig S. ; Bath, Philip M. / Lowering blood pressure after acute intracerebral haemorrhage : Protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC). In: BMJ Open. 2019 ; Vol. 9, No. 7. pp. 1DUMMY.
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abstract = "Introduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH. Methods and analysis A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of Individual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient's demographic, clinical and prestroke neuroradiological characteristics. Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals. PROSPERO registration number CRD42019141136.",
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AU - Wang, Xia

AU - Woodhouse, Lisa J.

AU - Law, Zhe Kang

AU - Delcourt, Candice

AU - Sprigg, Nikola

AU - Krishnan, Kailash

AU - Robinson, Thompson G.

AU - Wardlaw, Joanna M.

AU - Al-Shahi Salman, Rustam

AU - Berge, Eivind

AU - Sandset, Else C.

AU - Anderson, Craig S.

AU - Bath, Philip M.

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N2 - Introduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH. Methods and analysis A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of Individual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient's demographic, clinical and prestroke neuroradiological characteristics. Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals. PROSPERO registration number CRD42019141136.

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