Local specific Immunoglobulin E among patients with nonallergic rhinitis: a systematic review

Aneeza Khairiyah Wan Hamizan, Janet Rimmer, Salina Husain, Raquel Alvarado, Jessica Tatersall, William Sewell, Larry Kalish, Richard J. Harvey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Allergen specific immunoglobulin can be present in the nasal mucosa of patients with non-allergic rhinitis (NAR). This condition is defined as local allergic rhinitis. However, the reported presence of nasal specific immunoglobulin E (nspIgE) among NAR is variable. The aim of this review was to summarize the studies which reported the presence of nspIgE among patients diagnosed as NAR. METHODS: Embase (1947- ) and Medline (1946-) were searched until 6th June 2017. A search strategy was utilized to identify studies on nspIgE among patients with NAR. The target population was patients with symptoms of rhinitis, but negative systemic allergen sensitization. Studies with original data on detectable nspIgE among the NAR population were included. Meta-analysis of single proportions as a weighted probability %(95%CI) was performed. Heterogeneity was explored amongst studies. RESULTS: A search strategy returned 2286 studies and 21 were included. These studies involved 648 participants with NAR. NspIgE was detected using either; 1. nasal secretions, 2. epithelial mucosa sampling, 3. tissue biopsies or 4. In-situ tests. Metaanalysis was performed on studies with nasal secretions. The weighted proportion of detectable nspIgE in nasal secretions within patients with NAR was 10.2 (7.4-13.4) %. Population definitions partly explained variability. Detection of nspIgE was lower in patients without a history suggestive of allergy compared to those with a positive allergic history (0 (0-3.1) % v 19.8 (14.5-25.6) %, p<0.01). CONCLUSION: NAR with positive allergy history suggests presence of nspIgE. These patients warrant further allergology evaluation to confirm localized nasal allergy, as they benefit from allergy therapy such as immunotherapy.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalRhinology
Volume57
Issue number1
DOIs
Publication statusPublished - 1 Feb 2019

Fingerprint

Rhinitis
Nose
Immunoglobulin E
Hypersensitivity
Allergens
History
Nasal Mucosa
Health Services Needs and Demand
Immunotherapy
Population
Meta-Analysis
Immunoglobulins
Mucous Membrane
Biopsy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Local specific Immunoglobulin E among patients with nonallergic rhinitis : a systematic review. / Wan Hamizan, Aneeza Khairiyah; Rimmer, Janet; Husain, Salina; Alvarado, Raquel; Tatersall, Jessica; Sewell, William; Kalish, Larry; Harvey, Richard J.

In: Rhinology, Vol. 57, No. 1, 01.02.2019, p. 10-20.

Research output: Contribution to journalArticle

Wan Hamizan, AK, Rimmer, J, Husain, S, Alvarado, R, Tatersall, J, Sewell, W, Kalish, L & Harvey, RJ 2019, 'Local specific Immunoglobulin E among patients with nonallergic rhinitis: a systematic review', Rhinology, vol. 57, no. 1, pp. 10-20. https://doi.org/10.4193/Rhin18.074
Wan Hamizan, Aneeza Khairiyah ; Rimmer, Janet ; Husain, Salina ; Alvarado, Raquel ; Tatersall, Jessica ; Sewell, William ; Kalish, Larry ; Harvey, Richard J. / Local specific Immunoglobulin E among patients with nonallergic rhinitis : a systematic review. In: Rhinology. 2019 ; Vol. 57, No. 1. pp. 10-20.
@article{e1b055faf4974c43a79c056a4db2a133,
title = "Local specific Immunoglobulin E among patients with nonallergic rhinitis: a systematic review",
abstract = "BACKGROUND: Allergen specific immunoglobulin can be present in the nasal mucosa of patients with non-allergic rhinitis (NAR). This condition is defined as local allergic rhinitis. However, the reported presence of nasal specific immunoglobulin E (nspIgE) among NAR is variable. The aim of this review was to summarize the studies which reported the presence of nspIgE among patients diagnosed as NAR. METHODS: Embase (1947- ) and Medline (1946-) were searched until 6th June 2017. A search strategy was utilized to identify studies on nspIgE among patients with NAR. The target population was patients with symptoms of rhinitis, but negative systemic allergen sensitization. Studies with original data on detectable nspIgE among the NAR population were included. Meta-analysis of single proportions as a weighted probability {\%}(95{\%}CI) was performed. Heterogeneity was explored amongst studies. RESULTS: A search strategy returned 2286 studies and 21 were included. These studies involved 648 participants with NAR. NspIgE was detected using either; 1. nasal secretions, 2. epithelial mucosa sampling, 3. tissue biopsies or 4. In-situ tests. Metaanalysis was performed on studies with nasal secretions. The weighted proportion of detectable nspIgE in nasal secretions within patients with NAR was 10.2 (7.4-13.4) {\%}. Population definitions partly explained variability. Detection of nspIgE was lower in patients without a history suggestive of allergy compared to those with a positive allergic history (0 (0-3.1) {\%} v 19.8 (14.5-25.6) {\%}, p<0.01). CONCLUSION: NAR with positive allergy history suggests presence of nspIgE. These patients warrant further allergology evaluation to confirm localized nasal allergy, as they benefit from allergy therapy such as immunotherapy.",
author = "{Wan Hamizan}, {Aneeza Khairiyah} and Janet Rimmer and Salina Husain and Raquel Alvarado and Jessica Tatersall and William Sewell and Larry Kalish and Harvey, {Richard J.}",
year = "2019",
month = "2",
day = "1",
doi = "10.4193/Rhin18.074",
language = "English",
volume = "57",
pages = "10--20",
journal = "Rhinology",
issn = "0300-0729",
publisher = "University Hospital Utrecht",
number = "1",

}

TY - JOUR

T1 - Local specific Immunoglobulin E among patients with nonallergic rhinitis

T2 - a systematic review

AU - Wan Hamizan, Aneeza Khairiyah

AU - Rimmer, Janet

AU - Husain, Salina

AU - Alvarado, Raquel

AU - Tatersall, Jessica

AU - Sewell, William

AU - Kalish, Larry

AU - Harvey, Richard J.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - BACKGROUND: Allergen specific immunoglobulin can be present in the nasal mucosa of patients with non-allergic rhinitis (NAR). This condition is defined as local allergic rhinitis. However, the reported presence of nasal specific immunoglobulin E (nspIgE) among NAR is variable. The aim of this review was to summarize the studies which reported the presence of nspIgE among patients diagnosed as NAR. METHODS: Embase (1947- ) and Medline (1946-) were searched until 6th June 2017. A search strategy was utilized to identify studies on nspIgE among patients with NAR. The target population was patients with symptoms of rhinitis, but negative systemic allergen sensitization. Studies with original data on detectable nspIgE among the NAR population were included. Meta-analysis of single proportions as a weighted probability %(95%CI) was performed. Heterogeneity was explored amongst studies. RESULTS: A search strategy returned 2286 studies and 21 were included. These studies involved 648 participants with NAR. NspIgE was detected using either; 1. nasal secretions, 2. epithelial mucosa sampling, 3. tissue biopsies or 4. In-situ tests. Metaanalysis was performed on studies with nasal secretions. The weighted proportion of detectable nspIgE in nasal secretions within patients with NAR was 10.2 (7.4-13.4) %. Population definitions partly explained variability. Detection of nspIgE was lower in patients without a history suggestive of allergy compared to those with a positive allergic history (0 (0-3.1) % v 19.8 (14.5-25.6) %, p<0.01). CONCLUSION: NAR with positive allergy history suggests presence of nspIgE. These patients warrant further allergology evaluation to confirm localized nasal allergy, as they benefit from allergy therapy such as immunotherapy.

AB - BACKGROUND: Allergen specific immunoglobulin can be present in the nasal mucosa of patients with non-allergic rhinitis (NAR). This condition is defined as local allergic rhinitis. However, the reported presence of nasal specific immunoglobulin E (nspIgE) among NAR is variable. The aim of this review was to summarize the studies which reported the presence of nspIgE among patients diagnosed as NAR. METHODS: Embase (1947- ) and Medline (1946-) were searched until 6th June 2017. A search strategy was utilized to identify studies on nspIgE among patients with NAR. The target population was patients with symptoms of rhinitis, but negative systemic allergen sensitization. Studies with original data on detectable nspIgE among the NAR population were included. Meta-analysis of single proportions as a weighted probability %(95%CI) was performed. Heterogeneity was explored amongst studies. RESULTS: A search strategy returned 2286 studies and 21 were included. These studies involved 648 participants with NAR. NspIgE was detected using either; 1. nasal secretions, 2. epithelial mucosa sampling, 3. tissue biopsies or 4. In-situ tests. Metaanalysis was performed on studies with nasal secretions. The weighted proportion of detectable nspIgE in nasal secretions within patients with NAR was 10.2 (7.4-13.4) %. Population definitions partly explained variability. Detection of nspIgE was lower in patients without a history suggestive of allergy compared to those with a positive allergic history (0 (0-3.1) % v 19.8 (14.5-25.6) %, p<0.01). CONCLUSION: NAR with positive allergy history suggests presence of nspIgE. These patients warrant further allergology evaluation to confirm localized nasal allergy, as they benefit from allergy therapy such as immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=85060658042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060658042&partnerID=8YFLogxK

U2 - 10.4193/Rhin18.074

DO - 10.4193/Rhin18.074

M3 - Article

C2 - 30219822

AN - SCOPUS:85060658042

VL - 57

SP - 10

EP - 20

JO - Rhinology

JF - Rhinology

SN - 0300-0729

IS - 1

ER -