Living bilayered human skin equivalent: promising potentials for wound healing.

Mazlyzam Abdul Latif, B. S. Aminuddin, L. Saim, Ruszymah Idrus

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The angiogenic potential of native skin (NS), keratinocytes single skin equivalent (SSE-K), fibroblasts single skin equivalent (SSE-F) and bilayered skin equivalent secreting angiogenic growth factors such as transforming growth factor beta1 (TGF-beta1), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF) and basic fibroblast growth factor (bFGF) in the in vitro systems at 24, 48, 72 hours and 7 days was compared using Enzyme-Linked Immunosorbent Assay (ELISA). Bilayered skin equivalent exhibit highest release of growth factors within 24 hours to 7 days of culture compared to NS, SSE-K and SSE-F. This proved the potential of bilayered skin equivalent in producing and sustaining growth factors release to enhance angiogenesis, fibroblasts proliferation, matrix deposition, migration and growth of keratinocytes.

Original languageEnglish
Pages (from-to)32-33
Number of pages2
JournalThe Medical journal of Malaysia
Volume63 Suppl A
Publication statusPublished - Jul 2008

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Wound Healing
Skin
Intercellular Signaling Peptides and Proteins
Keratinocytes
Fibroblasts
Fibroblast Growth Factor 7
Transforming Growth Factor beta1
Angiogenesis Inducing Agents
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Enzyme-Linked Immunosorbent Assay
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Living bilayered human skin equivalent : promising potentials for wound healing. / Abdul Latif, Mazlyzam; Aminuddin, B. S.; Saim, L.; Idrus, Ruszymah.

In: The Medical journal of Malaysia, Vol. 63 Suppl A, 07.2008, p. 32-33.

Research output: Contribution to journalArticle

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