Abstract
Chronic and slow/non-healing wounds require extensive management to reduce the repair and recovery time. Wound dressings and devices are often designed to suit varying wound characteristics and strategically manage the complexity of different wound types. The main challenges in managing the chronic wound environment include: delivery of sufficient antimicrobial agent to maintain bioavailability at biocidal concentrations control of the quantity of wound exudate whilst promoting/maintaining the availability of pro-healing factors reduction of the risk of uneven antimicrobial deposition, lowering the risk of localized toxicity improvement in the ease of antimicrobial and wound dressing application reduction of the frequency of dressing changes thus minimising patient discomfort and avoid risk opportunity for further infection Topical administration of agents can require penetration through dead matter, purulent exudates and scar tissue as well as the dermis, which serves as the first line of defence. The dermal barrier has low permeability to large hydrophilic entities but will selectively allow permeation of small lipophilic molecules. Whilst essential for maintenance of host homeostasis, this limited permeability dramatically restricts delivery of many antimicrobial agents both to the wound surface as well as into the various layers of the dermis. These issues can be reduced with the aid of controlled release drug delivery systems such as liposomes, which can improve targeting, efficacy and the biopharmaceutical properties of the antimicrobial agent. Liposomes are biocompatible, biodegradable, lipid bilayer vesicles with a large aqueous inner-core for encapsulation and delivery of active agents. Encapsulation of antimicrobial agents in liposomes provides protection from enzymatic and immunological inactivation. Additionally, the liposome's capacity to bind water may aid moisture retention, which promotes an environment that is highly conducive to tissue repair. The capacity to transport both hydrophilic and hydrophobic materials, has allowed a wide range of pharmaceutical formulations to be incorporated into liposome vesicles. In terms of encapsulation, agents with varying lipophilicities can be sequestered within the phospholipid bilayer (hydrophobic), entrapped in the inner core (hydrophilic), as well as in the inner and outer bilayer interface (hydrophilic) of the liposome. This ability of liposomes to encapsulate antimicrobial agents with a broad range of physicochemical properties makes them valuable in wound management applications. This chapter will examine the diverse antimicrobial payloads, including antibiotics, antifungals, natural products and essential oils, which are amenable to liposome delivery and show enhanced therapeutic outcomes. The advantages of liposome encapsulated antimicrobials are their potential to achieve effective drug delivery whilst reducing problems related to targeting, biodistribution and bioavailability of microbiocidal agents.
| Original language | English |
|---|---|
| Title of host publication | Advances in Liposomes Research |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 27-61 |
| Number of pages | 35 |
| ISBN (Print) | 9781631170775, 9781631170744 |
| Publication status | Published - 1 Jan 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Liposomal delivery of antimicrobial agents in advances in liposome research. / Martin, Claire; Low, Wan Li; Gupta, Abhishek; Mohd Amin, Mohd Cairul Iqbal; Radecka, Iza; Raj, Prem; Britland, Stephen; Kenward, Ken.
Advances in Liposomes Research. Nova Science Publishers, Inc., 2014. p. 27-61.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Liposomal delivery of antimicrobial agents in advances in liposome research
AU - Martin, Claire
AU - Low, Wan Li
AU - Gupta, Abhishek
AU - Mohd Amin, Mohd Cairul Iqbal
AU - Radecka, Iza
AU - Raj, Prem
AU - Britland, Stephen
AU - Kenward, Ken
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Chronic and slow/non-healing wounds require extensive management to reduce the repair and recovery time. Wound dressings and devices are often designed to suit varying wound characteristics and strategically manage the complexity of different wound types. The main challenges in managing the chronic wound environment include: delivery of sufficient antimicrobial agent to maintain bioavailability at biocidal concentrations control of the quantity of wound exudate whilst promoting/maintaining the availability of pro-healing factors reduction of the risk of uneven antimicrobial deposition, lowering the risk of localized toxicity improvement in the ease of antimicrobial and wound dressing application reduction of the frequency of dressing changes thus minimising patient discomfort and avoid risk opportunity for further infection Topical administration of agents can require penetration through dead matter, purulent exudates and scar tissue as well as the dermis, which serves as the first line of defence. The dermal barrier has low permeability to large hydrophilic entities but will selectively allow permeation of small lipophilic molecules. Whilst essential for maintenance of host homeostasis, this limited permeability dramatically restricts delivery of many antimicrobial agents both to the wound surface as well as into the various layers of the dermis. These issues can be reduced with the aid of controlled release drug delivery systems such as liposomes, which can improve targeting, efficacy and the biopharmaceutical properties of the antimicrobial agent. Liposomes are biocompatible, biodegradable, lipid bilayer vesicles with a large aqueous inner-core for encapsulation and delivery of active agents. Encapsulation of antimicrobial agents in liposomes provides protection from enzymatic and immunological inactivation. Additionally, the liposome's capacity to bind water may aid moisture retention, which promotes an environment that is highly conducive to tissue repair. The capacity to transport both hydrophilic and hydrophobic materials, has allowed a wide range of pharmaceutical formulations to be incorporated into liposome vesicles. In terms of encapsulation, agents with varying lipophilicities can be sequestered within the phospholipid bilayer (hydrophobic), entrapped in the inner core (hydrophilic), as well as in the inner and outer bilayer interface (hydrophilic) of the liposome. This ability of liposomes to encapsulate antimicrobial agents with a broad range of physicochemical properties makes them valuable in wound management applications. This chapter will examine the diverse antimicrobial payloads, including antibiotics, antifungals, natural products and essential oils, which are amenable to liposome delivery and show enhanced therapeutic outcomes. The advantages of liposome encapsulated antimicrobials are their potential to achieve effective drug delivery whilst reducing problems related to targeting, biodistribution and bioavailability of microbiocidal agents.
AB - Chronic and slow/non-healing wounds require extensive management to reduce the repair and recovery time. Wound dressings and devices are often designed to suit varying wound characteristics and strategically manage the complexity of different wound types. The main challenges in managing the chronic wound environment include: delivery of sufficient antimicrobial agent to maintain bioavailability at biocidal concentrations control of the quantity of wound exudate whilst promoting/maintaining the availability of pro-healing factors reduction of the risk of uneven antimicrobial deposition, lowering the risk of localized toxicity improvement in the ease of antimicrobial and wound dressing application reduction of the frequency of dressing changes thus minimising patient discomfort and avoid risk opportunity for further infection Topical administration of agents can require penetration through dead matter, purulent exudates and scar tissue as well as the dermis, which serves as the first line of defence. The dermal barrier has low permeability to large hydrophilic entities but will selectively allow permeation of small lipophilic molecules. Whilst essential for maintenance of host homeostasis, this limited permeability dramatically restricts delivery of many antimicrobial agents both to the wound surface as well as into the various layers of the dermis. These issues can be reduced with the aid of controlled release drug delivery systems such as liposomes, which can improve targeting, efficacy and the biopharmaceutical properties of the antimicrobial agent. Liposomes are biocompatible, biodegradable, lipid bilayer vesicles with a large aqueous inner-core for encapsulation and delivery of active agents. Encapsulation of antimicrobial agents in liposomes provides protection from enzymatic and immunological inactivation. Additionally, the liposome's capacity to bind water may aid moisture retention, which promotes an environment that is highly conducive to tissue repair. The capacity to transport both hydrophilic and hydrophobic materials, has allowed a wide range of pharmaceutical formulations to be incorporated into liposome vesicles. In terms of encapsulation, agents with varying lipophilicities can be sequestered within the phospholipid bilayer (hydrophobic), entrapped in the inner core (hydrophilic), as well as in the inner and outer bilayer interface (hydrophilic) of the liposome. This ability of liposomes to encapsulate antimicrobial agents with a broad range of physicochemical properties makes them valuable in wound management applications. This chapter will examine the diverse antimicrobial payloads, including antibiotics, antifungals, natural products and essential oils, which are amenable to liposome delivery and show enhanced therapeutic outcomes. The advantages of liposome encapsulated antimicrobials are their potential to achieve effective drug delivery whilst reducing problems related to targeting, biodistribution and bioavailability of microbiocidal agents.
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M3 - Chapter
AN - SCOPUS:84949514430
SN - 9781631170775
SN - 9781631170744
SP - 27
EP - 61
BT - Advances in Liposomes Research
PB - Nova Science Publishers, Inc.
ER -