Penglipidan asid amino ringkas dan dwi-fungsi

Translated title of the contribution: Lipidization of simple and di-functional amino acids

Zainab Idris, Mohd Wahid Samsudin, Salmiah Ahmad

    Research output: Contribution to journalArticle

    Abstract

    This paper discuss the modification of azelaic acid into its applicable form by attachment of both its carboxyl sites to N-terminal of amino acid ethyl ester forming amide linkages in anhydrous medium. Acylation of glycine ethyl ester hydrochloride with azelaic acid dichloride was best conducted in a 100% anhydrous medium. L-amino acid ethyl ester bearing a primary hydroxyl group on its side chain gave mixtures of product and variation in composition depending on the mole ratio of reactants used. Reduction in purity was also observed for L-amino acid ethyl ester with primary -SH group on its side chain as compared to L-amino acid ethyl ester having -SCH3 group on the L-amino acid side chain. The diamidoester of azelaic acid with L-alanine ethyl ester, L-valine ethyl ester, L-leucine ethyl ester and L-glutamic acid diethyl ester were in good yield when prepared through the modified Schotten-Baumann reaction conditions.

    Original languageUndefined/Unknown
    Pages (from-to)193-199
    Number of pages7
    JournalMalaysian Journal of Analytical Sciences
    Volume17
    Issue number1
    Publication statusPublished - 2013

    Fingerprint

    Esters
    Amino Acids
    Bearings (structural)
    Acylation
    Valine
    Amides
    Leucine
    Alanine
    Hydroxyl Radical
    Glutamic Acid
    Chemical analysis
    azelaic acid

    Keywords

    • Azelaic acid dichloride
    • Glycine ethyl ester hydrochloride
    • L-amino acid ethyl ester
    • Schotten-bauman condition

    ASJC Scopus subject areas

    • Analytical Chemistry

    Cite this

    Idris, Z., Samsudin, M. W., & Ahmad, S. (2013). Penglipidan asid amino ringkas dan dwi-fungsi. Malaysian Journal of Analytical Sciences, 17(1), 193-199.

    Penglipidan asid amino ringkas dan dwi-fungsi. / Idris, Zainab; Samsudin, Mohd Wahid; Ahmad, Salmiah.

    In: Malaysian Journal of Analytical Sciences, Vol. 17, No. 1, 2013, p. 193-199.

    Research output: Contribution to journalArticle

    Idris, Z, Samsudin, MW & Ahmad, S 2013, 'Penglipidan asid amino ringkas dan dwi-fungsi', Malaysian Journal of Analytical Sciences, vol. 17, no. 1, pp. 193-199.
    Idris, Zainab ; Samsudin, Mohd Wahid ; Ahmad, Salmiah. / Penglipidan asid amino ringkas dan dwi-fungsi. In: Malaysian Journal of Analytical Sciences. 2013 ; Vol. 17, No. 1. pp. 193-199.
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