Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus

M. R. Azizah, S. S. Ainol, S. H. Kuak, N. C T Kong, Y. Normaznah, M. N. Rahim

Research output: Contribution to journalArticle

Abstract

Objective: Serum soluble IL-2 receptors (sIL2R) levels was determined in patients with systemic lupus erythematosus (SLE) to assess whether there was any relationship between serum levels of sIL2R and disease activity, and their clinical and serological parameters. Design: A cohort of 134 patients with SLE was enrolled into this study. The demographic, and previous clinical and serological features were obtained from medical records. They were also seen on follow-up for present clinical manifestations and blood obtained for serological work-out. Materials and Methods: Serum sIL2R levels was measured in 134 patients with SLE (122 females and 12 males, mean age: 34 years) using the technique of enzyme-linked immunosorbent assay (ELISA). Clinical activity was evaluated by the Lupus Activity Index. Results: Levels of sIL2R correlated significantly with disease activity (r=0.2261, p<0.05). We found a significant increase of sIL2R in the SLE group compared to controls {299±63pg/ml (mean±SEM) vs 103± 5pg/ml, p<0.05} and the active compared to the inactive groups (318.3±71 vs 162.4 ±63pg/m, p<0.05). However sIL2R levels were not significantly higher in the inactive group compared to normal individuals. Levels of sIL2R were found to correlate significantly with clinical manifestations; fatigue, central nervous system, renal and pulmonary involvements but did not correlate with anti ds DNA antibodies and levels of C3 and C4. We did not observe any significant differences in sIL2R levels between patients receiving steroids and those not on steroids. Conclusion: These findings suggest that serum soluble receptor of IL2 may represent a new potentially useful serological marker to monitor disease activity in patients with SLE.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalInternational Medical Journal
Volume8
Issue number4
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Interleukin-2 Receptors
Systemic Lupus Erythematosus
Serum
Steroids
Antinuclear Antibodies
Medical Records
Fatigue
Central Nervous System
Enzyme-Linked Immunosorbent Assay
Demography
Kidney
Lung
DNA

Keywords

  • Clinical
  • Disease activity
  • Immunology
  • SLE
  • Soluble IL-2R

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Azizah, M. R., Ainol, S. S., Kuak, S. H., Kong, N. C. T., Normaznah, Y., & Rahim, M. N. (2001). Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus. International Medical Journal, 8(4), 275-279.

Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus. / Azizah, M. R.; Ainol, S. S.; Kuak, S. H.; Kong, N. C T; Normaznah, Y.; Rahim, M. N.

In: International Medical Journal, Vol. 8, No. 4, 2001, p. 275-279.

Research output: Contribution to journalArticle

Azizah, MR, Ainol, SS, Kuak, SH, Kong, NCT, Normaznah, Y & Rahim, MN 2001, 'Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus', International Medical Journal, vol. 8, no. 4, pp. 275-279.
Azizah MR, Ainol SS, Kuak SH, Kong NCT, Normaznah Y, Rahim MN. Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus. International Medical Journal. 2001;8(4):275-279.
Azizah, M. R. ; Ainol, S. S. ; Kuak, S. H. ; Kong, N. C T ; Normaznah, Y. ; Rahim, M. N. / Levels of serum soluble interleukin-2 receptor in patients with systemic lupus erythematosus. In: International Medical Journal. 2001 ; Vol. 8, No. 4. pp. 275-279.
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