Large retrosternal parathyroid carcinoma with primary hyperparathyroidism

Geok Chin Tan, M. Sidik Shiran, Manickam Swaminathan, K. Seng Phang, Rohaizak Muhammad

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective tteatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathytoid carcinomas is quite vatiable; 5-year survival rates vary from 40% to 86%, while the 10-year survival rate is approximately 49%. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalAsian Journal of Surgery
Volume30
Issue number4
Publication statusPublished - Oct 2007

Fingerprint

Parathyroid Neoplasms
Primary Hyperparathyroidism
Hypercalcemia
Parathyroid Hormone
Survival Rate
Hyperparathyroidism
Alkaline Phosphatase
Differential Diagnosis
Neck
Calcium
Morbidity
Carcinoma
Kidney
Bone and Bones
Recurrence
Pain
Mortality
Serum

Keywords

  • Carcinoma
  • Endocrine
  • Hypercalcaemia
  • Hyperparathyroidism
  • Parathyroid

ASJC Scopus subject areas

  • Surgery

Cite this

Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. / Tan, Geok Chin; Shiran, M. Sidik; Swaminathan, Manickam; Phang, K. Seng; Muhammad, Rohaizak.

In: Asian Journal of Surgery, Vol. 30, No. 4, 10.2007, p. 286-289.

Research output: Contribution to journalArticle

Tan, GC, Shiran, MS, Swaminathan, M, Phang, KS & Muhammad, R 2007, 'Large retrosternal parathyroid carcinoma with primary hyperparathyroidism', Asian Journal of Surgery, vol. 30, no. 4, pp. 286-289.
Tan, Geok Chin ; Shiran, M. Sidik ; Swaminathan, Manickam ; Phang, K. Seng ; Muhammad, Rohaizak. / Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. In: Asian Journal of Surgery. 2007 ; Vol. 30, No. 4. pp. 286-289.
@article{be59651da30d4d588ed5056ad0a33752,
title = "Large retrosternal parathyroid carcinoma with primary hyperparathyroidism",
abstract = "Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1{\%} of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective tteatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathytoid carcinomas is quite vatiable; 5-year survival rates vary from 40{\%} to 86{\%}, while the 10-year survival rate is approximately 49{\%}. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.",
keywords = "Carcinoma, Endocrine, Hypercalcaemia, Hyperparathyroidism, Parathyroid",
author = "Tan, {Geok Chin} and Shiran, {M. Sidik} and Manickam Swaminathan and Phang, {K. Seng} and Rohaizak Muhammad",
year = "2007",
month = "10",
language = "English",
volume = "30",
pages = "286--289",
journal = "Asian Journal of Surgery",
issn = "1015-9584",
publisher = "Elsevier Taiwan LLC",
number = "4",

}

TY - JOUR

T1 - Large retrosternal parathyroid carcinoma with primary hyperparathyroidism

AU - Tan, Geok Chin

AU - Shiran, M. Sidik

AU - Swaminathan, Manickam

AU - Phang, K. Seng

AU - Muhammad, Rohaizak

PY - 2007/10

Y1 - 2007/10

N2 - Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective tteatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathytoid carcinomas is quite vatiable; 5-year survival rates vary from 40% to 86%, while the 10-year survival rate is approximately 49%. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.

AB - Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective tteatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathytoid carcinomas is quite vatiable; 5-year survival rates vary from 40% to 86%, while the 10-year survival rate is approximately 49%. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.

KW - Carcinoma

KW - Endocrine

KW - Hypercalcaemia

KW - Hyperparathyroidism

KW - Parathyroid

UR - http://www.scopus.com/inward/record.url?scp=35748978578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748978578&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 286

EP - 289

JO - Asian Journal of Surgery

JF - Asian Journal of Surgery

SN - 1015-9584

IS - 4

ER -