Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats

Wei Boon Yap, Faisal Malau Ahmad, Yi Cheng Lim, Satirah Zainalabidin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalKorean Journal of Physiology and Pharmacology
Volume20
Issue number6
DOIs
Publication statusPublished - 1 Nov 2016

Fingerprint

Lactobacillus casei
Inbred SHR Rats
Blood Vessels
Lactic Acid
Bacteria
Blood Pressure
Hypertension
Nitric Oxide
Probiotics
Body Fluids
Cardiovascular System
Serum
Vasodilation
Antihypertensive Agents
Glutathione
Wistar Rats
Suspensions
Arterial Pressure
Buffers
Stem Cells

Keywords

  • Antioxidant
  • Blood pressure
  • Nitric oxide
  • Probiotic
  • Vascular reactivity

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats. / Yap, Wei Boon; Ahmad, Faisal Malau; Lim, Yi Cheng; Zainalabidin, Satirah.

In: Korean Journal of Physiology and Pharmacology, Vol. 20, No. 6, 01.11.2016, p. 621-628.

Research output: Contribution to journalArticle

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