Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy

B. S. Haerian, K. S. Lim, E. H M Mohamed, Hui Jan Tan, C. T. Tan, Raymond Azman Ali, C. P. Wong, Sau Wei Wong, Z. Mohamed

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs). Overexpression of P-glycoprotein (P-gp) efflux transporter has been proposed to have a critical role in causing resistance to AEDs. P-gp is a product of the ATP-binding cassette subfamily B member 1 (ABCB1) gene. The purpose of this study was to investigate a possible link between ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes with response to carbamazepine (CBZ) or sodium valproate (VPA) monotherapy in Malaysian epilepsy patients. No ABCB1 haplotype association was found with response to either CBZ or VPA monotherapy in the Chinese, Indian, and Malay patients. C3435 allele carriers of the Indian males with cryptogenic epilepsy were more prone to resistance to either CBZ or VPA than carriers of T allele. Moreover, rs3789243T allele carriers of Malay females with symptomatic epilepsy were more resistant to either CBZ or VPA than C allele carriers. Our findings suggest that the ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.

Original languageEnglish
Pages (from-to)546-553
Number of pages8
JournalSeizure
Volume20
Issue number7
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Haplotypes
Carbamazepine
Valproic Acid
Epilepsy
Adenosine Triphosphate
Alleles
Anticonvulsants
P-Glycoprotein
Therapeutics
Genes

Keywords

  • ABCB1
  • Carbamazepine
  • Epilepsy
  • P-glycoprotein
  • Polymorphism
  • Sodium valproate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. / Haerian, B. S.; Lim, K. S.; Mohamed, E. H M; Tan, Hui Jan; Tan, C. T.; Ali, Raymond Azman; Wong, C. P.; Wong, Sau Wei; Mohamed, Z.

In: Seizure, Vol. 20, No. 7, 09.2011, p. 546-553.

Research output: Contribution to journalArticle

Haerian, B. S. ; Lim, K. S. ; Mohamed, E. H M ; Tan, Hui Jan ; Tan, C. T. ; Ali, Raymond Azman ; Wong, C. P. ; Wong, Sau Wei ; Mohamed, Z. / Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. In: Seizure. 2011 ; Vol. 20, No. 7. pp. 546-553.
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