Abstract
Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs). Overexpression of P-glycoprotein (P-gp) efflux transporter has been proposed to have a critical role in causing resistance to AEDs. P-gp is a product of the ATP-binding cassette subfamily B member 1 (ABCB1) gene. The purpose of this study was to investigate a possible link between ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes with response to carbamazepine (CBZ) or sodium valproate (VPA) monotherapy in Malaysian epilepsy patients. No ABCB1 haplotype association was found with response to either CBZ or VPA monotherapy in the Chinese, Indian, and Malay patients. C3435 allele carriers of the Indian males with cryptogenic epilepsy were more prone to resistance to either CBZ or VPA than carriers of T allele. Moreover, rs3789243T allele carriers of Malay females with symptomatic epilepsy were more resistant to either CBZ or VPA than C allele carriers. Our findings suggest that the ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 546-553 |
| Number of pages | 8 |
| Journal | Seizure |
| Volume | 20 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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Keywords
- ABCB1
- Carbamazepine
- Epilepsy
- P-glycoprotein
- Polymorphism
- Sodium valproate
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. / Haerian, B. S.; Lim, K. S.; Mohamed, E. H M; Tan, Hui Jan; Tan, C. T.; Ali, Raymond Azman; Wong, C. P.; Wong, Sau Wei; Mohamed, Z.
In: Seizure, Vol. 20, No. 7, 09.2011, p. 546-553.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy
AU - Haerian, B. S.
AU - Lim, K. S.
AU - Mohamed, E. H M
AU - Tan, Hui Jan
AU - Tan, C. T.
AU - Ali, Raymond Azman
AU - Wong, C. P.
AU - Wong, Sau Wei
AU - Mohamed, Z.
PY - 2011/9
Y1 - 2011/9
N2 - Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs). Overexpression of P-glycoprotein (P-gp) efflux transporter has been proposed to have a critical role in causing resistance to AEDs. P-gp is a product of the ATP-binding cassette subfamily B member 1 (ABCB1) gene. The purpose of this study was to investigate a possible link between ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes with response to carbamazepine (CBZ) or sodium valproate (VPA) monotherapy in Malaysian epilepsy patients. No ABCB1 haplotype association was found with response to either CBZ or VPA monotherapy in the Chinese, Indian, and Malay patients. C3435 allele carriers of the Indian males with cryptogenic epilepsy were more prone to resistance to either CBZ or VPA than carriers of T allele. Moreover, rs3789243T allele carriers of Malay females with symptomatic epilepsy were more resistant to either CBZ or VPA than C allele carriers. Our findings suggest that the ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
AB - Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs). Overexpression of P-glycoprotein (P-gp) efflux transporter has been proposed to have a critical role in causing resistance to AEDs. P-gp is a product of the ATP-binding cassette subfamily B member 1 (ABCB1) gene. The purpose of this study was to investigate a possible link between ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes with response to carbamazepine (CBZ) or sodium valproate (VPA) monotherapy in Malaysian epilepsy patients. No ABCB1 haplotype association was found with response to either CBZ or VPA monotherapy in the Chinese, Indian, and Malay patients. C3435 allele carriers of the Indian males with cryptogenic epilepsy were more prone to resistance to either CBZ or VPA than carriers of T allele. Moreover, rs3789243T allele carriers of Malay females with symptomatic epilepsy were more resistant to either CBZ or VPA than C allele carriers. Our findings suggest that the ABCB1 rs3789243 C > T, C1236T, G2677T/A, rs6949448 C > T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
KW - ABCB1
KW - Carbamazepine
KW - Epilepsy
KW - P-glycoprotein
KW - Polymorphism
KW - Sodium valproate
UR - http://www.scopus.com/inward/record.url?scp=79960922166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960922166&partnerID=8YFLogxK
U2 - 10.1016/j.seizure.2011.04.003
DO - 10.1016/j.seizure.2011.04.003
M3 - Article
C2 - 21530324
AN - SCOPUS:79960922166
VL - 20
SP - 546
EP - 553
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
IS - 7
ER -