Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease

Aroma Agape Gopalai, Shen Yang Lim, Zariah Abdul Aziz, Soo Kun Lim, Li Ping Tan, Yip Boon Chong, Chong Tin Tan, Santhi Puvanarajah, Shanti Viswanathan, Rishikesan Kuppusamy, Ai Huey Tan, Thien Thien Lim, Gaik Bee Eow, Norlinah Mohamed Ibrahim, Hui Hua Li, Yi Zhao, Azlina Ahmad-Annuar

Research output: Contribution to journalArticle

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Abstract

Introduction: The G2385R and R1628P LRRK2 gene variants have been associated with an increased risk of Parkinson's disease (PD) in the Asian population. Recently, a new LRRK2 gene variant, A419V, was reported to be a third risk variant for PD in Asian patients. Our objective was to investigate this finding in our cohort of Asian subjects. Materials and Methods: Eight hundred and twenty-eight subjects (404 PD patients, and 424 age and gender-matched control subjects without neurological disorders) were recruited. Genotyping was done by Taqman® allelic discrimination assay on an Applied Biosystems 7500 Fast Real-Time PCR machine. Results: The heterozygous A419V genotype was found in only 1 patient with PD, compared to 3 in the control group (0.4% vs 1.3%), giving an odds ratio of 0.35 (95% confidence interval (CI), 0.01 to 3.79; P = 0.624). Conclusion: A419V is not an important LRRK2 risk variant in our Asian cohort of patients with PD. Our data are further supported by a literature review which showed that 4 out of 6 published studies reported a negative association of this variant in PD.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalAnnals of the Academy of Medicine Singapore
Volume42
Issue number5
Publication statusPublished - May 2013

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Parkinson Disease
Nervous System Diseases
Genes
Real-Time Polymerase Chain Reaction
Odds Ratio
Genotype
Confidence Intervals
Control Groups
Population

Keywords

  • A419V
  • Asian
  • Genetics
  • LRRK2
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gopalai, A. A., Lim, S. Y., Abdul Aziz, Z., Lim, S. K., Tan, L. P., Chong, Y. B., ... Ahmad-Annuar, A. (2013). Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease. Annals of the Academy of Medicine Singapore, 42(5), 237-240.

Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease. / Gopalai, Aroma Agape; Lim, Shen Yang; Abdul Aziz, Zariah; Lim, Soo Kun; Tan, Li Ping; Chong, Yip Boon; Tan, Chong Tin; Puvanarajah, Santhi; Viswanathan, Shanti; Kuppusamy, Rishikesan; Tan, Ai Huey; Lim, Thien Thien; Eow, Gaik Bee; Mohamed Ibrahim, Norlinah; Li, Hui Hua; Zhao, Yi; Ahmad-Annuar, Azlina.

In: Annals of the Academy of Medicine Singapore, Vol. 42, No. 5, 05.2013, p. 237-240.

Research output: Contribution to journalArticle

Gopalai, AA, Lim, SY, Abdul Aziz, Z, Lim, SK, Tan, LP, Chong, YB, Tan, CT, Puvanarajah, S, Viswanathan, S, Kuppusamy, R, Tan, AH, Lim, TT, Eow, GB, Mohamed Ibrahim, N, Li, HH, Zhao, Y & Ahmad-Annuar, A 2013, 'Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease', Annals of the Academy of Medicine Singapore, vol. 42, no. 5, pp. 237-240.
Gopalai AA, Lim SY, Abdul Aziz Z, Lim SK, Tan LP, Chong YB et al. Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease. Annals of the Academy of Medicine Singapore. 2013 May;42(5):237-240.
Gopalai, Aroma Agape ; Lim, Shen Yang ; Abdul Aziz, Zariah ; Lim, Soo Kun ; Tan, Li Ping ; Chong, Yip Boon ; Tan, Chong Tin ; Puvanarajah, Santhi ; Viswanathan, Shanti ; Kuppusamy, Rishikesan ; Tan, Ai Huey ; Lim, Thien Thien ; Eow, Gaik Bee ; Mohamed Ibrahim, Norlinah ; Li, Hui Hua ; Zhao, Yi ; Ahmad-Annuar, Azlina. / Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease. In: Annals of the Academy of Medicine Singapore. 2013 ; Vol. 42, No. 5. pp. 237-240.
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AU - Tan, Li Ping

AU - Chong, Yip Boon

AU - Tan, Chong Tin

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AU - Tan, Ai Huey

AU - Lim, Thien Thien

AU - Eow, Gaik Bee

AU - Mohamed Ibrahim, Norlinah

AU - Li, Hui Hua

AU - Zhao, Yi

AU - Ahmad-Annuar, Azlina

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N2 - Introduction: The G2385R and R1628P LRRK2 gene variants have been associated with an increased risk of Parkinson's disease (PD) in the Asian population. Recently, a new LRRK2 gene variant, A419V, was reported to be a third risk variant for PD in Asian patients. Our objective was to investigate this finding in our cohort of Asian subjects. Materials and Methods: Eight hundred and twenty-eight subjects (404 PD patients, and 424 age and gender-matched control subjects without neurological disorders) were recruited. Genotyping was done by Taqman® allelic discrimination assay on an Applied Biosystems 7500 Fast Real-Time PCR machine. Results: The heterozygous A419V genotype was found in only 1 patient with PD, compared to 3 in the control group (0.4% vs 1.3%), giving an odds ratio of 0.35 (95% confidence interval (CI), 0.01 to 3.79; P = 0.624). Conclusion: A419V is not an important LRRK2 risk variant in our Asian cohort of patients with PD. Our data are further supported by a literature review which showed that 4 out of 6 published studies reported a negative association of this variant in PD.

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