Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: A case-control study and meta-analysis

Batoul Sadat Haerian, Kheng Seang Lim, Hui Jan Tan, Chee Piau Wong, Sau Wei Wong, Chong Tin Tan, Raymond Azman Ali, Zahurin Mohamed

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The SYN2 rs3773364 A>G polymorphism has been proposed to be involved in susceptibility to epilepsy, but research results have been inconclusive. The aim of this study was to investigate the association between the SYN2 rs3773364 A>G polymorphism and susceptibility against epilepsy in a case-control study and a meta-analysis. Methods: The SYN2 rs3773364 A>G polymorphism was successfully genotyped in 1182 samples (618 epilepsy patients) of Chinese, Indian, and Malay ethnicities. Meta-analysis of the related studies, including this case-control study, was performed under alternative genetic models. Results: Data from the case-control study indicated no allelic and genotypic association of this locus with susceptibility to epilepsy in the tri-ethnic Malaysian population. Similar finding was obtained by stratified analysis by epilepsy syndrome for idiopathic epilepsy. These results were verified by meta-analysis of the related pooled data. Conclusions: Our study indicated that SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy. Synapse 2011.

Original languageEnglish
Pages (from-to)1073-1079
Number of pages7
JournalSynapse
Volume65
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Synapsins
Meta-Analysis
Case-Control Studies
Epilepsy
Genes
Genetic Models
Synapses

Keywords

  • Epilepsy
  • Meta-analysis
  • Polymorphism
  • SYN2
  • Synapsin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy : A case-control study and meta-analysis. / Haerian, Batoul Sadat; Lim, Kheng Seang; Tan, Hui Jan; Wong, Chee Piau; Wong, Sau Wei; Tan, Chong Tin; Ali, Raymond Azman; Mohamed, Zahurin.

In: Synapse, Vol. 65, No. 10, 10.2011, p. 1073-1079.

Research output: Contribution to journalArticle

Haerian, Batoul Sadat ; Lim, Kheng Seang ; Tan, Hui Jan ; Wong, Chee Piau ; Wong, Sau Wei ; Tan, Chong Tin ; Ali, Raymond Azman ; Mohamed, Zahurin. / Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy : A case-control study and meta-analysis. In: Synapse. 2011 ; Vol. 65, No. 10. pp. 1073-1079.
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