Labisia pumila protects the bone of estrogen-deficient rat model: A histomorphometric study

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Abstract

Ethnopharmacological relevance: Labisia pumila var. alata (LP) is a phytoestrogenic herb with potential as an alternative to Estrogen Replacement Therapy (ERT) in the treatment of postmenopausal osteoporosis. LP has been reported to produce similar effects to ERT on the bone markers, but could not match ERT in terms of maintaining the bone calcium in postmenopausal osteoporosis rat model. This study aimed to examine in detail the effects of LP on the bone of postmenopausal osteoporosis rat model using bone histomorphometry. Materials and methods: Thirty two female rats were randomly divided into groups of: Sham operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var. alata (LP) and ovariectomized with ERT (Premarin®) (ERT). The LP and ERT were administered through the route of oral gavage daily at the dose of 17.5 mg/kg and 64.5 μg/kg respectively. Following 2 months of treatment, rats were euthanized and the left femurs were dissected out and prepared for bone histomorphometry. Results: Histomorphometric analysis revealed osteoporotic changes for the ovariectomized rats. Supplementation of LP to ovariectomized rats could prevent these osteoporotic changes, as effective as ERT. Conclusion: This confirmed that LP has potential as an alternative to ERT for prevention of postmenopausal osteoporosis.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJournal of Ethnopharmacology
Volume142
Issue number1
DOIs
Publication statusPublished - 26 Jun 2012

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Estrogen Replacement Therapy
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
Conjugated (USP) Estrogens
Femur
Calcium
Therapeutics

Keywords

  • Estrogen
  • Histomorphometry
  • Labisia pumila
  • Menopause
  • Osteoporosis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

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title = "Labisia pumila protects the bone of estrogen-deficient rat model: A histomorphometric study",
abstract = "Ethnopharmacological relevance: Labisia pumila var. alata (LP) is a phytoestrogenic herb with potential as an alternative to Estrogen Replacement Therapy (ERT) in the treatment of postmenopausal osteoporosis. LP has been reported to produce similar effects to ERT on the bone markers, but could not match ERT in terms of maintaining the bone calcium in postmenopausal osteoporosis rat model. This study aimed to examine in detail the effects of LP on the bone of postmenopausal osteoporosis rat model using bone histomorphometry. Materials and methods: Thirty two female rats were randomly divided into groups of: Sham operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var. alata (LP) and ovariectomized with ERT (Premarin{\circledR}) (ERT). The LP and ERT were administered through the route of oral gavage daily at the dose of 17.5 mg/kg and 64.5 μg/kg respectively. Following 2 months of treatment, rats were euthanized and the left femurs were dissected out and prepared for bone histomorphometry. Results: Histomorphometric analysis revealed osteoporotic changes for the ovariectomized rats. Supplementation of LP to ovariectomized rats could prevent these osteoporotic changes, as effective as ERT. Conclusion: This confirmed that LP has potential as an alternative to ERT for prevention of postmenopausal osteoporosis.",
keywords = "Estrogen, Histomorphometry, Labisia pumila, Menopause, Osteoporosis",
author = "Fathilah, {Siti Noor} and Shuid, {Ahmad Nazrun} and Norazlina Mohamed and Norliza Muhammad and Soelaiman, {Ima Nirwana}",
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AU - Shuid, Ahmad Nazrun

AU - Mohamed, Norazlina

AU - Muhammad, Norliza

AU - Soelaiman, Ima Nirwana

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