Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia.

S. Selvalingam, M. N. Mahmud, C. R. Thambidorai, Syed Zulkifli Syed Zakaria, N. Mohan, Isa, M. Sheila

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Sixty-one patients with biliary atresia, who underwent portoenterostomy (PE) between 1992 to 1998 in the Institute of Pediatrics, Kuala Lumpur and were followed for a period of one year, were studied to analyze the factors associated with jaundice clearance and cholangitis following PE. Sex distribution was equal. Majority of patients were Malays. Mean age in days at admission to the surgical ward was 66.90 +/- 23.36 and mean age at PE was 75.85 +/- 24.05. At the end of one-year follow-up, six patients (10%) had died, 35 (57%) developed one or more attacks of cholangitis, 35 (57%) had portal hypertension, eight (13%) liver failure and six patients had esophageal variceal bleeding. Thirty-three patients (54%) had jaundice clearance with a mean clearance time of 85 days after PE. The study shows that when the ductules in the porta hepatis were < 150 mu in size, persistence of jaundice after PE and the incidence of cholangitis in the first post-operative year were higher; patients with cholangitis in the first year had lower rate of jaundice clearance. Jaundice clearance was achieved in more patients when their postnatal age at the time of PE was lower but the relationship was not linear. Age at PE also did not have a linear temporal relationship to the incidence of cholangitis and the size of portal ductules. Prospective, multi-center based local studies on a bigger patient population are needed to identify other indicators of successful outcome following PE. This would help to define the indications for primary liver transplantation in the local population.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalThe Medical journal of Malaysia
Volume57
Issue number1
Publication statusPublished - Mar 2002

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Biliary Atresia
Cholangitis
Jaundice
Sex Distribution
Incidence
Liver Failure
Portal Hypertension
Liver Transplantation
Population
Statistical Factor Analysis
Pediatrics
Hemorrhage

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Selvalingam, S., Mahmud, M. N., Thambidorai, C. R., Syed Zakaria, S. Z., Mohan, N., Isa, & Sheila, M. (2002). Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia. The Medical journal of Malaysia, 57(1), 92-96.

Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia. / Selvalingam, S.; Mahmud, M. N.; Thambidorai, C. R.; Syed Zakaria, Syed Zulkifli; Mohan, N.; Isa; Sheila, M.

In: The Medical journal of Malaysia, Vol. 57, No. 1, 03.2002, p. 92-96.

Research output: Contribution to journalArticle

Selvalingam, S, Mahmud, MN, Thambidorai, CR, Syed Zakaria, SZ, Mohan, N, Isa & Sheila, M 2002, 'Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia.', The Medical journal of Malaysia, vol. 57, no. 1, pp. 92-96.
Selvalingam, S. ; Mahmud, M. N. ; Thambidorai, C. R. ; Syed Zakaria, Syed Zulkifli ; Mohan, N. ; Isa ; Sheila, M. / Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia. In: The Medical journal of Malaysia. 2002 ; Vol. 57, No. 1. pp. 92-96.
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