Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus

Osman Mesaik Mohammed Ahmed Hassan, Azizuddin, Shahnaz Murad, Khalid Mohammed Khan, Rasool Bakhsh Tareen, Aqeel Ahmed, Atta-ur-Rahman, Muhammad Iqbal Choudhary

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10-8 M) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T-cell (PMBC).

Original languageEnglish
Pages (from-to)1516-1520
Number of pages5
JournalPhytotherapy Research
Volume23
Issue number11
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

Fingerprint

Vitex
Flavonoids
T-Lymphocytes
Respiratory Burst
Chemotaxis
Luminescence
Monocytes
Neutrophils
Cell Proliferation
casticin

Keywords

  • Casticin
  • Flavonoid
  • Immunomodulatory properties
  • Monocyte oxidative burst inhibition
  • Verbenaceae
  • Vitex agnus-castus

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mohammed Ahmed Hassan, O. M., Azizuddin, Murad, S., Khan, K. M., Tareen, R. B., Ahmed, A., ... Choudhary, M. I. (2009). Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. Phytotherapy Research, 23(11), 1516-1520. https://doi.org/10.1002/ptr.2492

Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. / Mohammed Ahmed Hassan, Osman Mesaik; Azizuddin; Murad, Shahnaz; Khan, Khalid Mohammed; Tareen, Rasool Bakhsh; Ahmed, Aqeel; Atta-ur-Rahman; Choudhary, Muhammad Iqbal.

In: Phytotherapy Research, Vol. 23, No. 11, 11.2009, p. 1516-1520.

Research output: Contribution to journalArticle

Mohammed Ahmed Hassan, OM, Azizuddin, Murad, S, Khan, KM, Tareen, RB, Ahmed, A, Atta-ur-Rahman & Choudhary, MI 2009, 'Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus', Phytotherapy Research, vol. 23, no. 11, pp. 1516-1520. https://doi.org/10.1002/ptr.2492
Mohammed Ahmed Hassan, Osman Mesaik ; Azizuddin ; Murad, Shahnaz ; Khan, Khalid Mohammed ; Tareen, Rasool Bakhsh ; Ahmed, Aqeel ; Atta-ur-Rahman ; Choudhary, Muhammad Iqbal. / Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. In: Phytotherapy Research. 2009 ; Vol. 23, No. 11. pp. 1516-1520.
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