Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue

Izzatul Hidayah Azizan, Rozida Mohd. Khalid, Laily Din, Jalifah Latip

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Goniothalamin is a pharmacologically active styrylpyrone compound extracted from Goniothalamus species. It was found to be selectively preventing proliferation of several cancer cell lines without being cytotoxic towards normal cells. Further research on this compound and its derivatives revealed that some of the derivatives also possess anti proliferative activity. The purpose of this study is to synthesise goniothalamin derivatives via biotransformation of goniothalamin using an enzyme assay. Goniothalamin which was isolated from Goniothalamus andersonii, was allowed to react with dienelactone hydrolase for 30 minutes. The enzyme reaction's product was extracted and analysed using LC-MS. Based on the pseudomelecular ion, one goniothalamin analogue with dihydro functionality was obtained.

Original languageEnglish
Title of host publication2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1784
ISBN (Electronic)9780735414464
DOIs
Publication statusPublished - 17 Nov 2016
Event2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016 - Selangor, Malaysia
Duration: 13 Apr 201614 Apr 2016

Other

Other2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016
CountryMalaysia
CitySelangor
Period13/4/1614/4/16

Fingerprint

enzymes
isolation
analogs
cultured cells
reaction products
cancer
cells
ions

Keywords

  • biotransformation
  • dienelactone hydrolase
  • goniothalamin

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Azizan, I. H., Mohd. Khalid, R., Din, L., & Latip, J. (2016). Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium (Vol. 1784). [030010] American Institute of Physics Inc.. https://doi.org/10.1063/1.4966748

Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue. / Azizan, Izzatul Hidayah; Mohd. Khalid, Rozida; Din, Laily; Latip, Jalifah.

2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016. 030010.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Azizan, IH, Mohd. Khalid, R, Din, L & Latip, J 2016, Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue. in 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. vol. 1784, 030010, American Institute of Physics Inc., 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, Selangor, Malaysia, 13/4/16. https://doi.org/10.1063/1.4966748
Azizan IH, Mohd. Khalid R, Din L, Latip J. Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784. American Institute of Physics Inc. 2016. 030010 https://doi.org/10.1063/1.4966748
Azizan, Izzatul Hidayah ; Mohd. Khalid, Rozida ; Din, Laily ; Latip, Jalifah. / Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue. 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016.
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