Ischemic heart disease: Effectiveness and safety of statin treatment in a malaysian tertiary healthcare facility

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Abstract

Purpose: To determine the effectiveness and safety of statins in ischemic heart disease (IHD) patients in a Malaysian tertiary hospital. Methods: This cross-sectional observational study was conducted at Universiti Kebangsaan Malaysia (UKM) Medical Center, Kuala Lumpur, Malaysia and patients were included if they were diagnosed with IHD and treated on statins for three months, or had IHD with no statins prescribed. Results: A total of 72 patients admitted to the medical ward due to IHD were enrolled in this study. Fifty three of them were statin users and 19 patients had no history of statin treatment. The most commonly used statin was lovastatin (n = 42, 79.2 %), atorvastatin (n = 5, 9.4 %), simvastatin (n = 3, 5.7 %) and rosuvastatin (n = 3, 5.7 %). Risk factors found in the study population were dyslipidaemia (n = 52, 72 %), hypertension (n = 58, 80.1 %), diabetes (n = 36, 50 %), advanced age (n = 63, 87.5 %), smoking (n = 19, 26.4 %) and family history (n = 16, 22.2 %). Patients that were on statin were more likely to achieve targeted LDL-C levels compared to those that did not achieve LDL-C levels (X2 = 7.25, p = 0.007). There were also no difference in liver enzyme values between statin users and non-statin users. Conclusion: This study provides information regarding safety and efficacy of statins in the local population and the need for a more stringent approach in achieving targeted lipid levels in IHD patients.

Original languageEnglish
Pages (from-to)1793-1798
Number of pages6
JournalTropical Journal of Pharmaceutical Research
Volume15
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tertiary Healthcare
Myocardial Ischemia
Safety
Therapeutics
Malaysia
Lovastatin
Simvastatin
Dyslipidemias
Tertiary Care Centers
Population
Observational Studies
Cross-Sectional Studies
Smoking
Hypertension
Lipids

Keywords

  • Cardiovascular
  • Diabetes
  • Effectiveness of statins
  • Hypretension
  • Ischemic heart disease
  • Liverenzymes
  • Safety of statin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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title = "Ischemic heart disease: Effectiveness and safety of statin treatment in a malaysian tertiary healthcare facility",
abstract = "Purpose: To determine the effectiveness and safety of statins in ischemic heart disease (IHD) patients in a Malaysian tertiary hospital. Methods: This cross-sectional observational study was conducted at Universiti Kebangsaan Malaysia (UKM) Medical Center, Kuala Lumpur, Malaysia and patients were included if they were diagnosed with IHD and treated on statins for three months, or had IHD with no statins prescribed. Results: A total of 72 patients admitted to the medical ward due to IHD were enrolled in this study. Fifty three of them were statin users and 19 patients had no history of statin treatment. The most commonly used statin was lovastatin (n = 42, 79.2 {\%}), atorvastatin (n = 5, 9.4 {\%}), simvastatin (n = 3, 5.7 {\%}) and rosuvastatin (n = 3, 5.7 {\%}). Risk factors found in the study population were dyslipidaemia (n = 52, 72 {\%}), hypertension (n = 58, 80.1 {\%}), diabetes (n = 36, 50 {\%}), advanced age (n = 63, 87.5 {\%}), smoking (n = 19, 26.4 {\%}) and family history (n = 16, 22.2 {\%}). Patients that were on statin were more likely to achieve targeted LDL-C levels compared to those that did not achieve LDL-C levels (X2 = 7.25, p = 0.007). There were also no difference in liver enzyme values between statin users and non-statin users. Conclusion: This study provides information regarding safety and efficacy of statins in the local population and the need for a more stringent approach in achieving targeted lipid levels in IHD patients.",
keywords = "Cardiovascular, Diabetes, Effectiveness of statins, Hypretension, Ischemic heart disease, Liverenzymes, Safety of statin",
author = "Islahudin, {Farida Hanim} and {Md Salleh}, {Nur Hazalina} and Endang, {Kumolosasi Msi}",
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AU - Islahudin, Farida Hanim

AU - Md Salleh, Nur Hazalina

AU - Endang, Kumolosasi Msi

PY - 2016/8/1

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N2 - Purpose: To determine the effectiveness and safety of statins in ischemic heart disease (IHD) patients in a Malaysian tertiary hospital. Methods: This cross-sectional observational study was conducted at Universiti Kebangsaan Malaysia (UKM) Medical Center, Kuala Lumpur, Malaysia and patients were included if they were diagnosed with IHD and treated on statins for three months, or had IHD with no statins prescribed. Results: A total of 72 patients admitted to the medical ward due to IHD were enrolled in this study. Fifty three of them were statin users and 19 patients had no history of statin treatment. The most commonly used statin was lovastatin (n = 42, 79.2 %), atorvastatin (n = 5, 9.4 %), simvastatin (n = 3, 5.7 %) and rosuvastatin (n = 3, 5.7 %). Risk factors found in the study population were dyslipidaemia (n = 52, 72 %), hypertension (n = 58, 80.1 %), diabetes (n = 36, 50 %), advanced age (n = 63, 87.5 %), smoking (n = 19, 26.4 %) and family history (n = 16, 22.2 %). Patients that were on statin were more likely to achieve targeted LDL-C levels compared to those that did not achieve LDL-C levels (X2 = 7.25, p = 0.007). There were also no difference in liver enzyme values between statin users and non-statin users. Conclusion: This study provides information regarding safety and efficacy of statins in the local population and the need for a more stringent approach in achieving targeted lipid levels in IHD patients.

AB - Purpose: To determine the effectiveness and safety of statins in ischemic heart disease (IHD) patients in a Malaysian tertiary hospital. Methods: This cross-sectional observational study was conducted at Universiti Kebangsaan Malaysia (UKM) Medical Center, Kuala Lumpur, Malaysia and patients were included if they were diagnosed with IHD and treated on statins for three months, or had IHD with no statins prescribed. Results: A total of 72 patients admitted to the medical ward due to IHD were enrolled in this study. Fifty three of them were statin users and 19 patients had no history of statin treatment. The most commonly used statin was lovastatin (n = 42, 79.2 %), atorvastatin (n = 5, 9.4 %), simvastatin (n = 3, 5.7 %) and rosuvastatin (n = 3, 5.7 %). Risk factors found in the study population were dyslipidaemia (n = 52, 72 %), hypertension (n = 58, 80.1 %), diabetes (n = 36, 50 %), advanced age (n = 63, 87.5 %), smoking (n = 19, 26.4 %) and family history (n = 16, 22.2 %). Patients that were on statin were more likely to achieve targeted LDL-C levels compared to those that did not achieve LDL-C levels (X2 = 7.25, p = 0.007). There were also no difference in liver enzyme values between statin users and non-statin users. Conclusion: This study provides information regarding safety and efficacy of statins in the local population and the need for a more stringent approach in achieving targeted lipid levels in IHD patients.

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KW - Ischemic heart disease

KW - Liverenzymes

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