Iodized salt supplementation and its effects on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia

Kuang Kuay Lim, Ming Wong, Wan Nazaimoon Wan Mohamud, Nor Azmi Kamaruddin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: This research was performed to determine the prevalence of iodine deficiency disorder (IDD) and the effects of iodized salt supplementation on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia. Methods: Study respondents were from three target groups, i.e. pre-school children (PSC), primary school-going children (SGC) and adult women. Each household was supplied with iodized salt fortified with iodate fortificant for a period of 12 months and the iodine levels in the salt ranged from 20 to 30 μg/L. Samples collected before and after 6 and 12 months of introduction to iodized salt were urine from all groups, as well as serum samples from adult women. Results: A total of 200 respondents were recruited; 58 (29.0%) PSC, 65 (32.5%) SGC and 77 (38.5%) adult women. The median urine-iodine concentration (mUIC) in all groups were of moderately low before the iodized salt intervention, but increased significantly in all study groups after 6 and 12 months of intervention. However, at the end of the study, there was an increase in severe iodine deficiency (mUIC <20 μg/L) from 7.5% to 12% and about 9% of PSC and SGC respondents had mUIC level of more than 300 μg/L while the adult women showed a significant increase in free triiodothyronine (fT3) levels. Conclusion: The study demonstrated that iodized salt supplementation was able to show an improvement in iodine level amongst Orang Asli. However, an increase in severe iodine deficiency and iodine excess indicated that the iodized salt programme needs to be carefully monitored.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalAsia Pacific Journal of Clinical Nutrition
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Malaysia
Iodine
Thyroid Gland
Urine
Iodates
iodized salt
Triiodothyronine
Salts

Keywords

  • Hyperthyroidism
  • Iodine deficiency disorder
  • Iodized salt
  • Orang asli

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Iodized salt supplementation and its effects on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia. / Lim, Kuang Kuay; Wong, Ming; Wan Mohamud, Wan Nazaimoon; Kamaruddin, Nor Azmi.

In: Asia Pacific Journal of Clinical Nutrition, Vol. 22, No. 1, 01.2013, p. 41-47.

Research output: Contribution to journalArticle

@article{815f9727183844729f45f2966580834c,
title = "Iodized salt supplementation and its effects on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia",
abstract = "Background: This research was performed to determine the prevalence of iodine deficiency disorder (IDD) and the effects of iodized salt supplementation on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia. Methods: Study respondents were from three target groups, i.e. pre-school children (PSC), primary school-going children (SGC) and adult women. Each household was supplied with iodized salt fortified with iodate fortificant for a period of 12 months and the iodine levels in the salt ranged from 20 to 30 μg/L. Samples collected before and after 6 and 12 months of introduction to iodized salt were urine from all groups, as well as serum samples from adult women. Results: A total of 200 respondents were recruited; 58 (29.0{\%}) PSC, 65 (32.5{\%}) SGC and 77 (38.5{\%}) adult women. The median urine-iodine concentration (mUIC) in all groups were of moderately low before the iodized salt intervention, but increased significantly in all study groups after 6 and 12 months of intervention. However, at the end of the study, there was an increase in severe iodine deficiency (mUIC <20 μg/L) from 7.5{\%} to 12{\%} and about 9{\%} of PSC and SGC respondents had mUIC level of more than 300 μg/L while the adult women showed a significant increase in free triiodothyronine (fT3) levels. Conclusion: The study demonstrated that iodized salt supplementation was able to show an improvement in iodine level amongst Orang Asli. However, an increase in severe iodine deficiency and iodine excess indicated that the iodized salt programme needs to be carefully monitored.",
keywords = "Hyperthyroidism, Iodine deficiency disorder, Iodized salt, Orang asli",
author = "Lim, {Kuang Kuay} and Ming Wong and {Wan Mohamud}, {Wan Nazaimoon} and Kamaruddin, {Nor Azmi}",
year = "2013",
month = "1",
doi = "10.6133/apjcn.2013.22.1.02",
language = "English",
volume = "22",
pages = "41--47",
journal = "Asia Pacific Journal of Clinical Nutrition",
issn = "0964-7058",
publisher = "HEC Press",
number = "1",

}

TY - JOUR

T1 - Iodized salt supplementation and its effects on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia

AU - Lim, Kuang Kuay

AU - Wong, Ming

AU - Wan Mohamud, Wan Nazaimoon

AU - Kamaruddin, Nor Azmi

PY - 2013/1

Y1 - 2013/1

N2 - Background: This research was performed to determine the prevalence of iodine deficiency disorder (IDD) and the effects of iodized salt supplementation on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia. Methods: Study respondents were from three target groups, i.e. pre-school children (PSC), primary school-going children (SGC) and adult women. Each household was supplied with iodized salt fortified with iodate fortificant for a period of 12 months and the iodine levels in the salt ranged from 20 to 30 μg/L. Samples collected before and after 6 and 12 months of introduction to iodized salt were urine from all groups, as well as serum samples from adult women. Results: A total of 200 respondents were recruited; 58 (29.0%) PSC, 65 (32.5%) SGC and 77 (38.5%) adult women. The median urine-iodine concentration (mUIC) in all groups were of moderately low before the iodized salt intervention, but increased significantly in all study groups after 6 and 12 months of intervention. However, at the end of the study, there was an increase in severe iodine deficiency (mUIC <20 μg/L) from 7.5% to 12% and about 9% of PSC and SGC respondents had mUIC level of more than 300 μg/L while the adult women showed a significant increase in free triiodothyronine (fT3) levels. Conclusion: The study demonstrated that iodized salt supplementation was able to show an improvement in iodine level amongst Orang Asli. However, an increase in severe iodine deficiency and iodine excess indicated that the iodized salt programme needs to be carefully monitored.

AB - Background: This research was performed to determine the prevalence of iodine deficiency disorder (IDD) and the effects of iodized salt supplementation on thyroid status amongst Orang Asli in Hulu Selangor, Malaysia. Methods: Study respondents were from three target groups, i.e. pre-school children (PSC), primary school-going children (SGC) and adult women. Each household was supplied with iodized salt fortified with iodate fortificant for a period of 12 months and the iodine levels in the salt ranged from 20 to 30 μg/L. Samples collected before and after 6 and 12 months of introduction to iodized salt were urine from all groups, as well as serum samples from adult women. Results: A total of 200 respondents were recruited; 58 (29.0%) PSC, 65 (32.5%) SGC and 77 (38.5%) adult women. The median urine-iodine concentration (mUIC) in all groups were of moderately low before the iodized salt intervention, but increased significantly in all study groups after 6 and 12 months of intervention. However, at the end of the study, there was an increase in severe iodine deficiency (mUIC <20 μg/L) from 7.5% to 12% and about 9% of PSC and SGC respondents had mUIC level of more than 300 μg/L while the adult women showed a significant increase in free triiodothyronine (fT3) levels. Conclusion: The study demonstrated that iodized salt supplementation was able to show an improvement in iodine level amongst Orang Asli. However, an increase in severe iodine deficiency and iodine excess indicated that the iodized salt programme needs to be carefully monitored.

KW - Hyperthyroidism

KW - Iodine deficiency disorder

KW - Iodized salt

KW - Orang asli

UR - http://www.scopus.com/inward/record.url?scp=84873242345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873242345&partnerID=8YFLogxK

U2 - 10.6133/apjcn.2013.22.1.02

DO - 10.6133/apjcn.2013.22.1.02

M3 - Article

C2 - 23353609

AN - SCOPUS:84873242345

VL - 22

SP - 41

EP - 47

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

SN - 0964-7058

IS - 1

ER -