Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after stroke

A. W. Jahangir, Hui Jan Tan, Norlinah Mohamed Ibrahim, Wan Nur Nafisah Wan Yahya, Ramesh Sahathevan, B. B. Hamidon, Raymond Azman Ali

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Botulinum toxin is effective in reducing spasticity post stroke. As there are limited data on post stroke spasticity in Asia, we undertake this study to determine the effectiveness and safety of intramuscular injection of botulinum toxin type-A (BTX-A), in the treatment of chronic focal post-stroke hand spasticity, and the impact of BTX-A on the activities of daily living and quality of life, in comparison to placebo, in Malaysian stroke patients. This was a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of BTX-A in 27 subjects with wrist and finger spasticity after a stroke. The outcome measures were assessed with the Modified Ashworth Scale (MAS) to assess spasticity of the flexor muscles, Barthel Index (BI) for activities of daily living and EQ-5D and EQ VAS for quality of life. Assessments were performed at baseline and 1 and 3 months after injection. Compared to placebo, the BTX-A group had greater improvement in the flexor tone of the wrist and fingers (p=0.001 and p<0.001, respectively), at first month follow-up visit and sustained the improvement through to three months. Although there was an improvement in the measures of global function and quality of life in the BTX-A group, there was no significant improvement in between the two groups. No serious BTX-A related adverse effects were reported. The results of this study demonstrate that intramuscular injection of botulinum toxin A is safe and effective in the treatment of chronic focal post-stroke spasticity of the hand.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalMedical Journal of Malaysia
Volume62
Issue number4
Publication statusPublished - Oct 2007

Fingerprint

Type A Botulinum Toxins
Botulinum Toxins
Intramuscular Injections
Wrist
Fingers
Stroke
Placebos
Quality of Life
Activities of Daily Living
Therapeutics
Hand
Safety
Muscle Spasticity
Outcome Assessment (Health Care)
Injections

Keywords

  • Botulinum toxin A
  • Post stroke spasticity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after stroke. / Jahangir, A. W.; Tan, Hui Jan; Mohamed Ibrahim, Norlinah; Wan Yahya, Wan Nur Nafisah; Sahathevan, Ramesh; Hamidon, B. B.; Ali, Raymond Azman.

In: Medical Journal of Malaysia, Vol. 62, No. 4, 10.2007, p. 319-322.

Research output: Contribution to journalArticle

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