Intestinal microsporidiosis

A new entity in Malaysia?

A. H. Rukman, O. Malina, M. I. Noorhayati, M. Marlyn, A. Wan Omar, A. M. Roslaini, Z. Ngah, Norhayati Moktar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Intestinal microsporidia is an emerging human disease caused by microsporidia. A study was conducted to determine the prevalence of microsporidia in patients with gastro-intestinal symptoms and to examine the clinical manifestations associated with intestinal microsporidiosis. Methods: A descriptive cross-sectional study using a well-structured questionnaire; a review of medical records was also undertaken. Positive stool samples were defined as presence of one or more pinkish-violet ovoid structures with a belt-like stripe under high power field (100x) using modified gram-chromotrope stain (MGC). Results: A total of 353 faecal specimens of patients was examined and 100 patients were found to have positive stool samples for microsporidia. The overall prevalence of microsporidia was 28.3%. Acute and chronic diarrhoea were seen in 49.0% and 36.0% patients, respectively. The commonest clinical presentations were diarrhoea (85.0%) with 83.0 % of patients having loose or watery stools, vomiting (75.0%), foul-smelling stools (60.0%), nausea (59.0%) and cramping abdominal pain (39.0%). The least common symptoms were fever (15.0%), mucous in stool (5.0%) and blood in stool (4.0%). Conclusion: This study concludes that the prevalence of microsporidia is still high (28.3%) and the majority of patients (93.0%) are symptomatic; the most common gastro-intestinal symptom is diarrhoea with loose or watery stools. Hence, it is recommended that a stool screening for microsporidia be done in selected patients presented with gastrointestinal symptoms.

Original languageEnglish
Pages (from-to)11-24
Number of pages14
JournalMalaysian Journal of Medicine and Health Sciences
Volume4
Issue number2
Publication statusPublished - Jun 2008

Fingerprint

Microsporidiosis
Microsporidia
Malaysia
Diarrhea
Cross-Sectional Studies
Viola
Nausea
Abdominal Pain
Vomiting
Medical Records
Fever

Keywords

  • Diarrhoea
  • Gastrointestinal symptom
  • Intestinal microsporidia
  • Loose or watery stool
  • Modified gramchromotrope stain (MGC)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rukman, A. H., Malina, O., Noorhayati, M. I., Marlyn, M., Wan Omar, A., Roslaini, A. M., ... Moktar, N. (2008). Intestinal microsporidiosis: A new entity in Malaysia? Malaysian Journal of Medicine and Health Sciences, 4(2), 11-24.

Intestinal microsporidiosis : A new entity in Malaysia? / Rukman, A. H.; Malina, O.; Noorhayati, M. I.; Marlyn, M.; Wan Omar, A.; Roslaini, A. M.; Ngah, Z.; Moktar, Norhayati.

In: Malaysian Journal of Medicine and Health Sciences, Vol. 4, No. 2, 06.2008, p. 11-24.

Research output: Contribution to journalArticle

Rukman, AH, Malina, O, Noorhayati, MI, Marlyn, M, Wan Omar, A, Roslaini, AM, Ngah, Z & Moktar, N 2008, 'Intestinal microsporidiosis: A new entity in Malaysia?', Malaysian Journal of Medicine and Health Sciences, vol. 4, no. 2, pp. 11-24.
Rukman AH, Malina O, Noorhayati MI, Marlyn M, Wan Omar A, Roslaini AM et al. Intestinal microsporidiosis: A new entity in Malaysia? Malaysian Journal of Medicine and Health Sciences. 2008 Jun;4(2):11-24.
Rukman, A. H. ; Malina, O. ; Noorhayati, M. I. ; Marlyn, M. ; Wan Omar, A. ; Roslaini, A. M. ; Ngah, Z. ; Moktar, Norhayati. / Intestinal microsporidiosis : A new entity in Malaysia?. In: Malaysian Journal of Medicine and Health Sciences. 2008 ; Vol. 4, No. 2. pp. 11-24.
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abstract = "Objective: Intestinal microsporidia is an emerging human disease caused by microsporidia. A study was conducted to determine the prevalence of microsporidia in patients with gastro-intestinal symptoms and to examine the clinical manifestations associated with intestinal microsporidiosis. Methods: A descriptive cross-sectional study using a well-structured questionnaire; a review of medical records was also undertaken. Positive stool samples were defined as presence of one or more pinkish-violet ovoid structures with a belt-like stripe under high power field (100x) using modified gram-chromotrope stain (MGC). Results: A total of 353 faecal specimens of patients was examined and 100 patients were found to have positive stool samples for microsporidia. The overall prevalence of microsporidia was 28.3{\%}. Acute and chronic diarrhoea were seen in 49.0{\%} and 36.0{\%} patients, respectively. The commonest clinical presentations were diarrhoea (85.0{\%}) with 83.0 {\%} of patients having loose or watery stools, vomiting (75.0{\%}), foul-smelling stools (60.0{\%}), nausea (59.0{\%}) and cramping abdominal pain (39.0{\%}). The least common symptoms were fever (15.0{\%}), mucous in stool (5.0{\%}) and blood in stool (4.0{\%}). Conclusion: This study concludes that the prevalence of microsporidia is still high (28.3{\%}) and the majority of patients (93.0{\%}) are symptomatic; the most common gastro-intestinal symptom is diarrhoea with loose or watery stools. Hence, it is recommended that a stool screening for microsporidia be done in selected patients presented with gastrointestinal symptoms.",
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