InterRNA

A database of base interactions in RNA structures

Sri Devan Appasamy, Hazrina Yusof Hamdani, Effirul Ikhwan Ramlan, Mohd Firdaus Mohd Raih

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A major component of RNA structure stabilization are the hydrogen bonded interactions between the base residues. The importance and biological relevance for large clusters of base interactions can be much more easily investigated when their occurrences have been systematically detected, catalogued and compared. In this paper, we describe the database InterRNA (INTERactions in RNA structures database-http://mfrlab.org/interrna/) that contains records of known RNA 3D motifs as well as records for clusters of bases that are interconnected by hydrogen bonds. The contents of the database were compiled from RNA structural annotations carried out by the NASSAM (http://mfrlab.org/grafss/nassam) and COGNAC (http://mfrlab.org/grafss/cognac) computer programs. An analysis of the database content and comparisons with the existing corpus of knowledge regarding RNA 3D motifs clearly show that InterRNA is able to provide an extension of the annotations for known motifs as well as able to provide novel interactions for further investigations.

Original languageEnglish
Pages (from-to)D266-D271
JournalNucleic Acids Research
Volume44
Issue numberD1
DOIs
Publication statusPublished - 2016

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Nucleotide Motifs
Databases
RNA
Hydrogen
Nucleic Acid Databases
Software

ASJC Scopus subject areas

  • Genetics

Cite this

InterRNA : A database of base interactions in RNA structures. / Appasamy, Sri Devan; Hamdani, Hazrina Yusof; Ramlan, Effirul Ikhwan; Mohd Raih, Mohd Firdaus.

In: Nucleic Acids Research, Vol. 44, No. D1, 2016, p. D266-D271.

Research output: Contribution to journalArticle

Appasamy, Sri Devan ; Hamdani, Hazrina Yusof ; Ramlan, Effirul Ikhwan ; Mohd Raih, Mohd Firdaus. / InterRNA : A database of base interactions in RNA structures. In: Nucleic Acids Research. 2016 ; Vol. 44, No. D1. pp. D266-D271.
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