Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice

Marzieh Jabbarzare, Voon Kin Chin, Herni Talib, Mun Fei Yam, Siti Khadijah Adam, Haniza Hassan, Roslaini Abdul Majid, Che Norma Mat Taib, Mohamad Aris Mohd Moklas, Mohamad Taufik Hidayat, Hasidah Mohd. Sidek, Rusliza Basir

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice. Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treat-ment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney. Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice. Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.

Original languageEnglish
Pages (from-to)389-401
Number of pages13
JournalIranian Journal of Parasitology
Volume10
Issue number3
Publication statusPublished - 1 Sep 2015

Fingerprint

Interleukin-18
Malaria
Infection
Plasmodium berghei
Inbred ICR Mouse
Parasitic Diseases
Spleen
Kidney
Lung
Liver

Keywords

  • Histopathology
  • Interleukin-18
  • Malaria
  • Plasmodium berghei

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Jabbarzare, M., Chin, V. K., Talib, H., Yam, M. F., Adam, S. K., Hassan, H., ... Basir, R. (2015). Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice. Iranian Journal of Parasitology, 10(3), 389-401.

Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice. / Jabbarzare, Marzieh; Chin, Voon Kin; Talib, Herni; Yam, Mun Fei; Adam, Siti Khadijah; Hassan, Haniza; Abdul Majid, Roslaini; Mat Taib, Che Norma; Mohd Moklas, Mohamad Aris; Taufik Hidayat, Mohamad; Mohd. Sidek, Hasidah; Basir, Rusliza.

In: Iranian Journal of Parasitology, Vol. 10, No. 3, 01.09.2015, p. 389-401.

Research output: Contribution to journalArticle

Jabbarzare, M, Chin, VK, Talib, H, Yam, MF, Adam, SK, Hassan, H, Abdul Majid, R, Mat Taib, CN, Mohd Moklas, MA, Taufik Hidayat, M, Mohd. Sidek, H & Basir, R 2015, 'Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice', Iranian Journal of Parasitology, vol. 10, no. 3, pp. 389-401.
Jabbarzare M, Chin VK, Talib H, Yam MF, Adam SK, Hassan H et al. Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice. Iranian Journal of Parasitology. 2015 Sep 1;10(3):389-401.
Jabbarzare, Marzieh ; Chin, Voon Kin ; Talib, Herni ; Yam, Mun Fei ; Adam, Siti Khadijah ; Hassan, Haniza ; Abdul Majid, Roslaini ; Mat Taib, Che Norma ; Mohd Moklas, Mohamad Aris ; Taufik Hidayat, Mohamad ; Mohd. Sidek, Hasidah ; Basir, Rusliza. / Interleukin-18 antagonism improved histopathological conditions of malaria infection in mice. In: Iranian Journal of Parasitology. 2015 ; Vol. 10, No. 3. pp. 389-401.
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