Interaction of metal complexes with G-quadruplex DNA

Savvas N. Georgiades, Nurul Huda Abd Karim, Kogularamanan Suntharalingam, Ramon Vilar

Research output: Contribution to journalArticle

302 Citations (Scopus)

Abstract

[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome, guanine-rich sequences with the potential to form G-quadruplexes exist in the telomere as well as in promoter regions of certain oncogenes. The identification of these sequences as novel targets for the development of anticancer drugs has sparked great interest in the design of molecules that can interact with quadruplex DNA. While most reported quadruplex DNA binders are based on purely organic templates, numerous metal complexes have more recently been shown to interact effectively with this DNA secondary structure. This Review provides an overview of the important roles that metal complexes can play as quadruplex DNA binding molecules, highlighting the unique properties metals can confer to these molecules.

Original languageEnglish
Pages (from-to)4020-4034
Number of pages15
JournalAngewandte Chemie - International Edition
Volume49
Issue number24
DOIs
Publication statusPublished - 1 Jun 2010
Externally publishedYes

Fingerprint

Coordination Complexes
Metal complexes
DNA
Guanine
Molecules
Genetic Promoter Regions
Binders
Genes
Metals
Pharmaceutical Preparations

Keywords

  • Anticancer drug
  • Bioinorganic chemistry
  • G-quadruplex DNA
  • Medical chemistry
  • Molecular probes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Interaction of metal complexes with G-quadruplex DNA. / Georgiades, Savvas N.; Abd Karim, Nurul Huda; Suntharalingam, Kogularamanan; Vilar, Ramon.

In: Angewandte Chemie - International Edition, Vol. 49, No. 24, 01.06.2010, p. 4020-4034.

Research output: Contribution to journalArticle

Georgiades, Savvas N. ; Abd Karim, Nurul Huda ; Suntharalingam, Kogularamanan ; Vilar, Ramon. / Interaction of metal complexes with G-quadruplex DNA. In: Angewandte Chemie - International Edition. 2010 ; Vol. 49, No. 24. pp. 4020-4034.
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