Interaction of imipenem and tigecycline against carbapenem-resistant Acinetobacter baumanii

The relativity of synergism

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log<inf>10</inf> CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections.

Original languageEnglish
Pages (from-to)1061-1065
Number of pages5
JournalSains Malaysiana
Volume44
Issue number7
Publication statusPublished - 1 Jul 2015

Fingerprint

Acinetobacter
Carbapenems
Imipenem
Anti-Bacterial Agents
Cross Infection
Anti-Infective Agents
Infection
tigecycline
Bacteria

Keywords

  • Acinetobacter baumanii
  • Carbapenem-resistant
  • Imipenem
  • Tigecycline

ASJC Scopus subject areas

  • General

Cite this

Interaction of imipenem and tigecycline against carbapenem-resistant Acinetobacter baumanii : The relativity of synergism. / Hanafiah, Alfizah; Sarah, O. Z Siti; Mohamad Zin, Noraziah.

In: Sains Malaysiana, Vol. 44, No. 7, 01.07.2015, p. 1061-1065.

Research output: Contribution to journalArticle

@article{a96b53bc553345569396ffbe0b1db540,
title = "Interaction of imipenem and tigecycline against carbapenem-resistant Acinetobacter baumanii: The relativity of synergism",
abstract = "Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log10 CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections.",
keywords = "Acinetobacter baumanii, Carbapenem-resistant, Imipenem, Tigecycline",
author = "Alfizah Hanafiah and Sarah, {O. Z Siti} and {Mohamad Zin}, Noraziah",
year = "2015",
month = "7",
day = "1",
language = "English",
volume = "44",
pages = "1061--1065",
journal = "Sains Malaysiana",
issn = "0126-6039",
publisher = "Penerbit Universiti Kebangsaan Malaysia",
number = "7",

}

TY - JOUR

T1 - Interaction of imipenem and tigecycline against carbapenem-resistant Acinetobacter baumanii

T2 - The relativity of synergism

AU - Hanafiah, Alfizah

AU - Sarah, O. Z Siti

AU - Mohamad Zin, Noraziah

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log10 CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections.

AB - Acinetobacter baumanii is an opportunistic bacterium that causes widespread nosocomial infections and tends to be multi-resistant to most of antibiotics. Tigecycline is a well-known antibiotic that possesses a wide-range of activities and is very active in vitro towards a variety of resistant pathogens, including A. baumanii. The aim of this study was to evaluate the effects of the imipenem and tigecycline combination against carbapenem-resistant A. baumanii (CRAB). The minimal inhibitory concentration (MIC) was determined using the E-test method. The microbroth checkerboard technique was employed to determine the effects of the imipenem and tigecycline interaction by obtaining the fractional inhibitory concentration (FIC) index value. A time kill (TK) study was performed to identify any synergistic effects when both imipenem and tigecycline were used against CRAB strains. The result demonstrated that all A. baumanni strains exhibited imipenem MIC values of 32 μg/mL. The combination of imipenem and tigecycline demonstrated an additive effect (FIC > 0.5-4) against all of the strains and synergistic activity (decrement of > 2 log10 CFU/mL) towards AC 34/07 and AC 32/06 strains. The use of imipenem in combination with tigecycline resulted in a more efficient activity and an increased capability to control CRAB infections. This effect showed potential combination and may be of importance in the development or modification of antimicrobial agents for the treatment of CRAB infections.

KW - Acinetobacter baumanii

KW - Carbapenem-resistant

KW - Imipenem

KW - Tigecycline

UR - http://www.scopus.com/inward/record.url?scp=84941080686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941080686&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 1061

EP - 1065

JO - Sains Malaysiana

JF - Sains Malaysiana

SN - 0126-6039

IS - 7

ER -