Interaction of antimicrobial peptides and bacterial cell membrane to combat MDR problem: An overview

Sahlil Miraz Mohamed Rafie, Darman Nordin, Nurina Anuar

Research output: Contribution to journalArticle

Abstract

The discovery of multi-drug resistant (MDR) microorganisms has created urgency in the demand for research towards the discovery of new antibiotics. There are many ways in which microorganism such as bacteria can become antibiotics resistant, for example: the overuse of antibiotics, evolution in bacterial DNA and the transference of antibiotic-resistant gene from one microorganism to microorganism. In order to combat the problem of MDR, it is important to study the interactions of antibiotics with the bacterial cell membrane. Antimicrobial peptides (AMPs) have been considered as potential novel antibiotics. There are few mechanisms action of AMPs in bacterial membrane have been discussed by previous study such as carpet like, membrane thinning, aggregate, toroidal pore and Barrel-starve.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalMalaysian Journal of Biochemistry and Molecular Biology
Volume22
Issue number1
Publication statusPublished - 1 Jan 2019

Fingerprint

Cell membranes
Cell Membrane
Anti-Bacterial Agents
Microorganisms
Peptides
Pharmaceutical Preparations
Membranes
Bacterial DNA
Drug Discovery
Bacteria
Genes
Research

Keywords

  • Antimicrobial peptide
  • Bacteria cell membrane
  • Lipid peptide interaction
  • Mechanism action
  • Multi drug resistance

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Interaction of antimicrobial peptides and bacterial cell membrane to combat MDR problem : An overview. / Rafie, Sahlil Miraz Mohamed; Nordin, Darman; Anuar, Nurina.

In: Malaysian Journal of Biochemistry and Molecular Biology, Vol. 22, No. 1, 01.01.2019, p. 130-133.

Research output: Contribution to journalArticle

@article{f6956e2a128442f9903ac04560e0f348,
title = "Interaction of antimicrobial peptides and bacterial cell membrane to combat MDR problem: An overview",
abstract = "The discovery of multi-drug resistant (MDR) microorganisms has created urgency in the demand for research towards the discovery of new antibiotics. There are many ways in which microorganism such as bacteria can become antibiotics resistant, for example: the overuse of antibiotics, evolution in bacterial DNA and the transference of antibiotic-resistant gene from one microorganism to microorganism. In order to combat the problem of MDR, it is important to study the interactions of antibiotics with the bacterial cell membrane. Antimicrobial peptides (AMPs) have been considered as potential novel antibiotics. There are few mechanisms action of AMPs in bacterial membrane have been discussed by previous study such as carpet like, membrane thinning, aggregate, toroidal pore and Barrel-starve.",
keywords = "Antimicrobial peptide, Bacteria cell membrane, Lipid peptide interaction, Mechanism action, Multi drug resistance",
author = "Rafie, {Sahlil Miraz Mohamed} and Darman Nordin and Nurina Anuar",
year = "2019",
month = "1",
day = "1",
language = "English",
volume = "22",
pages = "130--133",
journal = "Malaysian Journal of Biochemistry and Molecular Biology",
issn = "1511-2616",
publisher = "Malaysian Society for Biochemistry and Molecular Biology",
number = "1",

}

TY - JOUR

T1 - Interaction of antimicrobial peptides and bacterial cell membrane to combat MDR problem

T2 - An overview

AU - Rafie, Sahlil Miraz Mohamed

AU - Nordin, Darman

AU - Anuar, Nurina

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The discovery of multi-drug resistant (MDR) microorganisms has created urgency in the demand for research towards the discovery of new antibiotics. There are many ways in which microorganism such as bacteria can become antibiotics resistant, for example: the overuse of antibiotics, evolution in bacterial DNA and the transference of antibiotic-resistant gene from one microorganism to microorganism. In order to combat the problem of MDR, it is important to study the interactions of antibiotics with the bacterial cell membrane. Antimicrobial peptides (AMPs) have been considered as potential novel antibiotics. There are few mechanisms action of AMPs in bacterial membrane have been discussed by previous study such as carpet like, membrane thinning, aggregate, toroidal pore and Barrel-starve.

AB - The discovery of multi-drug resistant (MDR) microorganisms has created urgency in the demand for research towards the discovery of new antibiotics. There are many ways in which microorganism such as bacteria can become antibiotics resistant, for example: the overuse of antibiotics, evolution in bacterial DNA and the transference of antibiotic-resistant gene from one microorganism to microorganism. In order to combat the problem of MDR, it is important to study the interactions of antibiotics with the bacterial cell membrane. Antimicrobial peptides (AMPs) have been considered as potential novel antibiotics. There are few mechanisms action of AMPs in bacterial membrane have been discussed by previous study such as carpet like, membrane thinning, aggregate, toroidal pore and Barrel-starve.

KW - Antimicrobial peptide

KW - Bacteria cell membrane

KW - Lipid peptide interaction

KW - Mechanism action

KW - Multi drug resistance

UR - http://www.scopus.com/inward/record.url?scp=85071950934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071950934&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85071950934

VL - 22

SP - 130

EP - 133

JO - Malaysian Journal of Biochemistry and Molecular Biology

JF - Malaysian Journal of Biochemistry and Molecular Biology

SN - 1511-2616

IS - 1

ER -