Interaction between insulin-like growth factor-1 with other growth factors in serum depleted culture medium for human cartilage engineering.

Chua Kien Hui, B. S. Aminuddin, N. H. Fuzina, Ruszymah Idrus

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The regulation roles of insulin-like growth factor-1 (IGF-1) with basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in human nasal septum chondrocytes monolayer culture and cartilage engineering was investigated in this study. The role of IGF-1 with bFGF and TGFbeta2 was investigated by measuring chondrocyte growth kinetic and collagen genes expression. IGF-1 together with bFGF and TGFbeta2 promote cartilage tissue engineering, increase type II collagen expression and enhance the histological features of engineered cartilage.

Original languageEnglish
Pages (from-to)7-8
Number of pages2
JournalThe Medical journal of Malaysia
Volume59 Suppl B
Publication statusPublished - May 2004

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Human Engineering
Somatomedins
Fibroblast Growth Factor 2
Cartilage
Culture Media
Intercellular Signaling Peptides and Proteins
Chondrocytes
Transforming Growth Factor beta
Serum
Nasal Septum
Collagen Type II
Tissue Engineering
Collagen
Gene Expression
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The regulation roles of insulin-like growth factor-1 (IGF-1) with basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in human nasal septum chondrocytes monolayer culture and cartilage engineering was investigated in this study. The role of IGF-1 with bFGF and TGFbeta2 was investigated by measuring chondrocyte growth kinetic and collagen genes expression. IGF-1 together with bFGF and TGFbeta2 promote cartilage tissue engineering, increase type II collagen expression and enhance the histological features of engineered cartilage.",
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AB - The regulation roles of insulin-like growth factor-1 (IGF-1) with basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in human nasal septum chondrocytes monolayer culture and cartilage engineering was investigated in this study. The role of IGF-1 with bFGF and TGFbeta2 was investigated by measuring chondrocyte growth kinetic and collagen genes expression. IGF-1 together with bFGF and TGFbeta2 promote cartilage tissue engineering, increase type II collagen expression and enhance the histological features of engineered cartilage.

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