Integrated high magnetic gradient system for trapping nanoparticles

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lab-on-chip (LoC) magnetic separator is important in clinical diagnostics and biological studies where different types of biological cells need to be isolated from its heterogeneous population. In this work, a novel design of on-chip V-shaped magnetic core generating high magnetic gradient and force for trapping magnetically labelled bioparticles is presented. The integrated magnetic system consisted of a spiral-shaped planar microcoils and a V-shaped permalloy (Ni80Fe20) magnetic core structure, which was designed to be part of LoC separator system. The effects of V-shaped magnetic core tip area, the current injection to the microcoils on the magnetic field, as well as its gradient and force on magnetic nanoparticles were simulated and analyzed. Finite element analysis (FEA) simulation using two dimensional (2D) axial symmetry model and steady state analysis of the DC magnetostatics module confirmed the effect of V-shaped magnetic core tip on the high magnetic field generation. The smallest Vshaped magnetic core tip area and the highest current injected to the magnetic coils had significantly amplified the magnetic flux density, its gradient, and the magnetic force generated on a magnetic nanoparticles. Functional test results justified the proportional relationship between DC applied and the trapping area of the magnetic nanoparticles. Effective separation of biological cells tagged with magnetic nanoparticles in LoC system was expected with integration of this high gradient onchip magnetic system.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalJurnal Teknologi
Volume75
Issue number11
DOIs
Publication statusPublished - 3 Sep 2015

Fingerprint

Magnetic cores
Nanoparticles
Magnetic separators
Magnetic fields
Magnetostatics
Magnetic flux
Separators
Finite element method

Keywords

  • Bioparticles
  • High magnetic gradient
  • Lab-on-chip (LoC)
  • Microfluidics
  • Nanoparticles
  • V-shaped magnetic core

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Integrated high magnetic gradient system for trapping nanoparticles. / Abidin, Ummikalsom; Yeop Majlis, Burhanuddin; Yunas, Jumril.

In: Jurnal Teknologi, Vol. 75, No. 11, 03.09.2015, p. 151-160.

Research output: Contribution to journalArticle

@article{a6c1cf6ed2504e0893975f0d4c6aca9d,
title = "Integrated high magnetic gradient system for trapping nanoparticles",
abstract = "Lab-on-chip (LoC) magnetic separator is important in clinical diagnostics and biological studies where different types of biological cells need to be isolated from its heterogeneous population. In this work, a novel design of on-chip V-shaped magnetic core generating high magnetic gradient and force for trapping magnetically labelled bioparticles is presented. The integrated magnetic system consisted of a spiral-shaped planar microcoils and a V-shaped permalloy (Ni80Fe20) magnetic core structure, which was designed to be part of LoC separator system. The effects of V-shaped magnetic core tip area, the current injection to the microcoils on the magnetic field, as well as its gradient and force on magnetic nanoparticles were simulated and analyzed. Finite element analysis (FEA) simulation using two dimensional (2D) axial symmetry model and steady state analysis of the DC magnetostatics module confirmed the effect of V-shaped magnetic core tip on the high magnetic field generation. The smallest Vshaped magnetic core tip area and the highest current injected to the magnetic coils had significantly amplified the magnetic flux density, its gradient, and the magnetic force generated on a magnetic nanoparticles. Functional test results justified the proportional relationship between DC applied and the trapping area of the magnetic nanoparticles. Effective separation of biological cells tagged with magnetic nanoparticles in LoC system was expected with integration of this high gradient onchip magnetic system.",
keywords = "Bioparticles, High magnetic gradient, Lab-on-chip (LoC), Microfluidics, Nanoparticles, V-shaped magnetic core",
author = "Ummikalsom Abidin and {Yeop Majlis}, Burhanuddin and Jumril Yunas",
year = "2015",
month = "9",
day = "3",
doi = "10.11113/jt.v75.5344",
language = "English",
volume = "75",
pages = "151--160",
journal = "Jurnal Teknologi",
issn = "0127-9696",
publisher = "Penerbit Universiti Teknologi Malaysia",
number = "11",

}

TY - JOUR

T1 - Integrated high magnetic gradient system for trapping nanoparticles

AU - Abidin, Ummikalsom

AU - Yeop Majlis, Burhanuddin

AU - Yunas, Jumril

PY - 2015/9/3

Y1 - 2015/9/3

N2 - Lab-on-chip (LoC) magnetic separator is important in clinical diagnostics and biological studies where different types of biological cells need to be isolated from its heterogeneous population. In this work, a novel design of on-chip V-shaped magnetic core generating high magnetic gradient and force for trapping magnetically labelled bioparticles is presented. The integrated magnetic system consisted of a spiral-shaped planar microcoils and a V-shaped permalloy (Ni80Fe20) magnetic core structure, which was designed to be part of LoC separator system. The effects of V-shaped magnetic core tip area, the current injection to the microcoils on the magnetic field, as well as its gradient and force on magnetic nanoparticles were simulated and analyzed. Finite element analysis (FEA) simulation using two dimensional (2D) axial symmetry model and steady state analysis of the DC magnetostatics module confirmed the effect of V-shaped magnetic core tip on the high magnetic field generation. The smallest Vshaped magnetic core tip area and the highest current injected to the magnetic coils had significantly amplified the magnetic flux density, its gradient, and the magnetic force generated on a magnetic nanoparticles. Functional test results justified the proportional relationship between DC applied and the trapping area of the magnetic nanoparticles. Effective separation of biological cells tagged with magnetic nanoparticles in LoC system was expected with integration of this high gradient onchip magnetic system.

AB - Lab-on-chip (LoC) magnetic separator is important in clinical diagnostics and biological studies where different types of biological cells need to be isolated from its heterogeneous population. In this work, a novel design of on-chip V-shaped magnetic core generating high magnetic gradient and force for trapping magnetically labelled bioparticles is presented. The integrated magnetic system consisted of a spiral-shaped planar microcoils and a V-shaped permalloy (Ni80Fe20) magnetic core structure, which was designed to be part of LoC separator system. The effects of V-shaped magnetic core tip area, the current injection to the microcoils on the magnetic field, as well as its gradient and force on magnetic nanoparticles were simulated and analyzed. Finite element analysis (FEA) simulation using two dimensional (2D) axial symmetry model and steady state analysis of the DC magnetostatics module confirmed the effect of V-shaped magnetic core tip on the high magnetic field generation. The smallest Vshaped magnetic core tip area and the highest current injected to the magnetic coils had significantly amplified the magnetic flux density, its gradient, and the magnetic force generated on a magnetic nanoparticles. Functional test results justified the proportional relationship between DC applied and the trapping area of the magnetic nanoparticles. Effective separation of biological cells tagged with magnetic nanoparticles in LoC system was expected with integration of this high gradient onchip magnetic system.

KW - Bioparticles

KW - High magnetic gradient

KW - Lab-on-chip (LoC)

KW - Microfluidics

KW - Nanoparticles

KW - V-shaped magnetic core

UR - http://www.scopus.com/inward/record.url?scp=84940736171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940736171&partnerID=8YFLogxK

U2 - 10.11113/jt.v75.5344

DO - 10.11113/jt.v75.5344

M3 - Article

VL - 75

SP - 151

EP - 160

JO - Jurnal Teknologi

JF - Jurnal Teknologi

SN - 0127-9696

IS - 11

ER -