Insulin-like growth factor II gene expression by congenital mesoblastic nephroma

N. A. Sharifah, K. Yun, J. McLay

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We studied the expression of insulin-like growth factor II (IGF2) and Wilms' tumor gene (WT1) in nine cases of congenital mesoblastic nephroma (CMN) and five cases of first trimester fetal kidneys by in situ hybridization. Our aim was to determine their site of expression and to correlate their histogenetic relationship to those of other childhood renal tumors. Our results showed that all nine cases of CMN (classic, mixed, and cellular) contained abundant IGF2 but not WT1 transcripts. The IGF2 transcripts were diffusely distributed over the tumor cells. These findings suggest that CMN is derived from primitive mesenchymal nephrogenic cells and have a potential to differentiate into a stromal cell lineage.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalDiagnostic Molecular Pathology
Volume4
Issue number4
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Mesoblastic Nephroma
Insulin-Like Growth Factor II
Gene Expression
Wilms' Tumor Genes
Kidney
Cell Lineage
First Pregnancy Trimester
Stromal Cells
In Situ Hybridization
Neoplasms

Keywords

  • Congenital mesoblastic nephroma
  • Histogenesis
  • IGF2
  • In situ hybridization (ISH)
  • Wilms' tumor
  • WT1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Insulin-like growth factor II gene expression by congenital mesoblastic nephroma. / Sharifah, N. A.; Yun, K.; McLay, J.

In: Diagnostic Molecular Pathology, Vol. 4, No. 4, 1995, p. 279-285.

Research output: Contribution to journalArticle

Sharifah, N. A. ; Yun, K. ; McLay, J. / Insulin-like growth factor II gene expression by congenital mesoblastic nephroma. In: Diagnostic Molecular Pathology. 1995 ; Vol. 4, No. 4. pp. 279-285.
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