Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma

Sharifah Noor Akmal, Kankatsu Yun, Janet MacLay, Yoshikazu Higami, Takayoshi Ikeda

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation. The data suggested that IGF2 and IGFBP2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma.

Original languageEnglish
Pages (from-to)846-851
Number of pages6
JournalHuman Pathology
Volume26
Issue number8
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Insulin-Like Growth Factor Binding Protein 2
Hepatoblastoma
Somatomedins
Digoxigenin
In Situ Hybridization
Cell Differentiation
Gene Expression
Messenger RNA
Neoplasms

Keywords

  • differentiation
  • hepatoblastoma
  • IGF2
  • IGFBP2
  • in situ hybridization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma. / Akmal, Sharifah Noor; Yun, Kankatsu; MacLay, Janet; Higami, Yoshikazu; Ikeda, Takayoshi.

In: Human Pathology, Vol. 26, No. 8, 1995, p. 846-851.

Research output: Contribution to journalArticle

Akmal, Sharifah Noor ; Yun, Kankatsu ; MacLay, Janet ; Higami, Yoshikazu ; Ikeda, Takayoshi. / Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma. In: Human Pathology. 1995 ; Vol. 26, No. 8. pp. 846-851.
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