Insulin-like growth factor-1 is a mediator of age-related decline of bone health status in men

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The role of insulin-like growth factor-1 (IGF-1) in bone health in men is debatable. This study aimed to determine whether IGF-1 is a mediator in age-related decline of bone health status measured by calcaneal speed of sound (SOS) in Malaysian men. Methods: The study recruited 279 Chinese and Malay men. Their demographic data, weight, height, calcaneal SOS were taken and fasting blood was collected for total testosterone, sex-hormone binding globulin and IGF-1 assays. The associations between the studied variables were assessed using multiple linear regression (MLR) analysis. Mediator analysis was performed using Sobel test. Results: There was a significant and parallel decrease of IGF-1 and SOS with age (p < 0.05). Serum IGF-1 was significantly and positively associated with SOS (p < 0.05) but after further adjustment for age, the significance was lost (p > 0.05). The strength of the association between age and SOS decreased after adjusting for IGF-1 level but it remained significant (p < 0.05). Sobel test revealed that IGF-1 was a significant partial mediator in the relationship between age and SOS (z = -4.3). Conclusion: Serum IGF-1 is a partial mediator in the age-related decline of bone health in men as determined by calcaneal ultrasound. A prospective study should be performed to validate this relationship.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalAging Male
Volume17
Issue number2
DOIs
Publication statusPublished - 2014

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Somatomedins
Health Status
Bone and Bones
Men's Health
Sex Hormone-Binding Globulin
Testosterone
Linear Models
Fasting
Regression Analysis
Demography
Prospective Studies
Weights and Measures
Serum

Keywords

  • Bone
  • Calcaneus
  • Insulin-like growth factor
  • Men
  • Quantitative ultrasound

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Insulin-like growth factor-1 is a mediator of age-related decline of bone health status in men. / Kok Yong, Chin; Soelaiman, Ima Nirwana; Naina Mohamed, Isa; Hanapi Johari, Mohamad; Ahmad, Fairus; Mohd Ramli, Elvy Suhana; Wan Ngah, Wan Zurinah.

In: Aging Male, Vol. 17, No. 2, 2014, p. 102-106.

Research output: Contribution to journalArticle

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AU - Wan Ngah, Wan Zurinah

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