Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Poh Yen Khor, Mohd Fadhlizil Fasihi Mohd Aluwi, Kamal Rullah, Kok Wai Lam

Research output: Contribution to journalShort survey

Abstract

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.

Original languageEnglish
Article number111704
JournalEuropean Journal of Medicinal Chemistry
Volume183
DOIs
Publication statusPublished - 1 Dec 2019

Fingerprint

Curcumin
Bioactivity
Derivatives
Pharmacokinetics
Pharmaceutical Preparations
Medicine
Molecules

Keywords

  • Asymmetric curcumin
  • Bioactivity
  • Diketone
  • Monoketone
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. / Khor, Poh Yen; Mohd Aluwi, Mohd Fadhlizil Fasihi; Rullah, Kamal; Lam, Kok Wai.

In: European Journal of Medicinal Chemistry, Vol. 183, 111704, 01.12.2019.

Research output: Contribution to journalShort survey

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