Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment

Rohaina Che Man, Nadiah Sulaiman, Ruszymah Bt Hj Idrus, Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab, Muhammad Dain Yazid

Research output: Contribution to journalReview article

Abstract

Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selected. The primary search identified 36 articles with the utilized keywords; however, only 13 articles met the defined inclusion criteria. Eight out of thirteen articles included in vivo and in vitro studies. We classified the dental stem cell-derived secretome with its nerve regeneration potential. All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.

Original languageEnglish
Article number4596150
JournalStem Cells International
Volume2019
DOIs
Publication statusPublished - 1 Jan 2019

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Nerve Regeneration
Tooth
Stem Cells
Stem Cell Factor
PubMed
Neurodegenerative Diseases
Regeneration
Research Personnel
Databases
Wounds and Injuries

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration : Towards Cell-Free Treatment. / Man, Rohaina Che; Sulaiman, Nadiah; Idrus, Ruszymah Bt Hj; Ariffin, Shahrul Hisham Zainal; Wahab, Rohaya Megat Abdul; Yazid, Muhammad Dain.

In: Stem Cells International, Vol. 2019, 4596150, 01.01.2019.

Research output: Contribution to journalReview article

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