Inhibitory effects of xanthones on platelet activating factor receptor binding in vitro

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nine naturally occurring xanthones were investigated for their platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. 2-(3-methylbut-2-enyl)-1,3,5-trihydoxyxanthone, macluraxanthone, 1,3,5-trihydroxy-6,6′-dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)xanthone, 6-deoxyjacareubin and 2-(3-methylbut-2-enyl)-1,3,5,6-terahydroxyxanthone showed strong inhibition with IC50 values of 4.8, 11.0, 21.0, 29.0 and 44.0 μM, respectively. The prenyl group at C-2, the dimethylprop-2-enyl group at C-4 and the hydroxyl group at C-5 are all beneficial to the binding of xanthones to the PAF receptor. The results revealed that xanthones can represent a new class of natural PAF receptor antagonists.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalJournal of Ethnopharmacology
Volume75
Issue number2-3
DOIs
Publication statusPublished - 2001

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Xanthones
Hydroxyl Radical
Inhibitory Concentration 50
Blood Platelets
Rabbits
In Vitro Techniques
platelet activating factor receptor

Keywords

  • Platelet activating factor antagonists
  • Platelets
  • Xanthones

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inhibitory effects of xanthones on platelet activating factor receptor binding in vitro. / Jantan, Ibrahim; Jalil, Juriyati; Abd Warif, Nor Malia.

In: Journal of Ethnopharmacology, Vol. 75, No. 2-3, 2001, p. 287-290.

Research output: Contribution to journalArticle

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