Inhibitory Effects of Mitrella kentii Extracts on Inflammatory Mediators’ Biosynthesis and Binding

Malina Jasamai, Juriyati Jalil, Sakina Saadawi, Ibrahim Jantan

Research output: Contribution to journalArticle

Abstract

The inhibitory effects of Mitrella kentii leaf and stem extracts on the production prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and antagonist effect on platelet-activating factor (PAF) receptor binding were evaluated. The inhibition of PGE2 and TXB2 productions were determined using the radioimmunoassay technique, and the inhibitory effect of PAF receptor binding to rabbit platelet was determined using the 3H-PAF as a ligand. Among the extracts tested, ethyl acetate, methanol and hexane leaf extracts, and methanol stems extract showed inhibitory effects on PGE2 and TXB2 productions and antagonistic effect on PAF receptor binding. M. kentii extracts may have the potential of being developed as supplements for inflammatory conditions.

Original languageEnglish
JournalJournal of Herbs, Spices and Medicinal Plants
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Thromboxane B2
Dinoprostone
Methanol
Platelet Activating Factor
Hexanes
Radioimmunoassay
Blood Platelets
Rabbits
Ligands
platelet activating factor receptor
prostaglandin B2

Keywords

  • blood platelets
  • platelet activating factor
  • Prostaglandin E
  • radioimmunoassay
  • thromboxane B

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine

Cite this

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abstract = "The inhibitory effects of Mitrella kentii leaf and stem extracts on the production prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and antagonist effect on platelet-activating factor (PAF) receptor binding were evaluated. The inhibition of PGE2 and TXB2 productions were determined using the radioimmunoassay technique, and the inhibitory effect of PAF receptor binding to rabbit platelet was determined using the 3H-PAF as a ligand. Among the extracts tested, ethyl acetate, methanol and hexane leaf extracts, and methanol stems extract showed inhibitory effects on PGE2 and TXB2 productions and antagonistic effect on PAF receptor binding. M. kentii extracts may have the potential of being developed as supplements for inflammatory conditions.",
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AU - Jasamai, Malina

AU - Jalil, Juriyati

AU - Saadawi, Sakina

AU - Jantan, Ibrahim

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AB - The inhibitory effects of Mitrella kentii leaf and stem extracts on the production prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and antagonist effect on platelet-activating factor (PAF) receptor binding were evaluated. The inhibition of PGE2 and TXB2 productions were determined using the radioimmunoassay technique, and the inhibitory effect of PAF receptor binding to rabbit platelet was determined using the 3H-PAF as a ligand. Among the extracts tested, ethyl acetate, methanol and hexane leaf extracts, and methanol stems extract showed inhibitory effects on PGE2 and TXB2 productions and antagonistic effect on PAF receptor binding. M. kentii extracts may have the potential of being developed as supplements for inflammatory conditions.

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