Inhibitory effects of compounds from zingiberaceae species on platelet activating factor receptor binding

Ibrahim Jantan, Mazura Pisar, Hasnah Mohd Sirat, Norazah Basar, Shajarahtunnur Jamil, Rasadah Mat Ali, Juriyati Jalil

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 μM, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4′, 6′-trimethoxychalcone from K. rotunda were 45.6 and 57.4 μM, respectively. 1-Methoxy-2-methyl-5-(1′,5′-dimethylhex-4′-enyl) -benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 μM. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors.

Original languageEnglish
Pages (from-to)1005-1007
Number of pages3
JournalPhytotherapy Research
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Zingiberaceae
Platelet Activating Factor
Inhibitory Concentration 50
Methylation
Platelets
Benzene
Alpinia
Curcuma
Ligands
Blood Platelets
Rabbits
platelet activating factor receptor

Keywords

  • Alpinia mutica
  • Antagonistic activities
  • Curcuma xanthorrhiza
  • Kaempferia rotunda
  • Platelet-activating factor (PAF)
  • Zingiberaceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Inhibitory effects of compounds from zingiberaceae species on platelet activating factor receptor binding. / Jantan, Ibrahim; Pisar, Mazura; Sirat, Hasnah Mohd; Basar, Norazah; Jamil, Shajarahtunnur; Ali, Rasadah Mat; Jalil, Juriyati.

In: Phytotherapy Research, Vol. 18, No. 12, 12.2004, p. 1005-1007.

Research output: Contribution to journalArticle

Jantan, Ibrahim ; Pisar, Mazura ; Sirat, Hasnah Mohd ; Basar, Norazah ; Jamil, Shajarahtunnur ; Ali, Rasadah Mat ; Jalil, Juriyati. / Inhibitory effects of compounds from zingiberaceae species on platelet activating factor receptor binding. In: Phytotherapy Research. 2004 ; Vol. 18, No. 12. pp. 1005-1007.
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