Kesan perencatan madu gelam terhadap kehilangan tulang pada tikus periodontitis

Translated title of the contribution: Inhibitory effect of gelam honey on bone loss in periodontitis rat

Afifah Radiah Fauzi, Saliana A. Aziz, Norashikin Hamzah, Badiah Baharin, Norzana Abd. Ghafar, Mariati Abdul Rahman

Research output: Contribution to journalArticle

Abstract

Periodontitis is a chronic disease which results in alveolar bone loss and inflammation at the periodontal gingival tissue. Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) are the crucial pro-inflammatory markers in periodontitis. Twenty Sprague-Dawley rats were divided into four groups: which was control group (CS); control treated with Gelam honey (3 g/mL) (CH); periodontitis group (TS); and periodontitis treated with Gelam honey (3 g/mL) (TH). The periodontitis was induced by ligating 4/0 suture on the left first molar tooth. After 15 days, the plasma and tissue samples were analysed using Elisa and histological staining. Alveolar bone loss was the highest in the TS group compared to control groups, CS and CH, but there was no significant difference compared to TH group. Immunohistochemistry staining showed positive expression of IL-6 and TNF-α in periodontium was significantly higher percentage in TS group compared to TH group which was 49.27% (IL-6) and 31.73% (TNF-α), respectively. However, there was no significant difference in plasma level of IL-6 and TNF-α.

Original languageIndonesian
Pages (from-to)1923-1930
Number of pages8
JournalSains Malaysiana
Volume45
Issue number12
Publication statusPublished - 1 Dec 2016

Fingerprint

Honey
Periodontitis
Interleukin-6
Bone and Bones
Tumor Necrosis Factor-alpha
Alveolar Bone Loss
Staining and Labeling
Periodontium
Osteitis
Control Groups
Sutures
Sprague Dawley Rats
Tooth
Chronic Disease
Immunohistochemistry

Keywords

  • Bone loss
  • Honey
  • Inflammatory mediators
  • Periodontitis

ASJC Scopus subject areas

  • General

Cite this

Kesan perencatan madu gelam terhadap kehilangan tulang pada tikus periodontitis. / Fauzi, Afifah Radiah; Aziz, Saliana A.; Hamzah, Norashikin; Baharin, Badiah; Abd. Ghafar, Norzana; Abdul Rahman, Mariati.

In: Sains Malaysiana, Vol. 45, No. 12, 01.12.2016, p. 1923-1930.

Research output: Contribution to journalArticle

Fauzi, Afifah Radiah ; Aziz, Saliana A. ; Hamzah, Norashikin ; Baharin, Badiah ; Abd. Ghafar, Norzana ; Abdul Rahman, Mariati. / Kesan perencatan madu gelam terhadap kehilangan tulang pada tikus periodontitis. In: Sains Malaysiana. 2016 ; Vol. 45, No. 12. pp. 1923-1930.
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