Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation

Ibrahim Jantan, S. M. Raweh, H. M. Sirat, S. Jamil, Y. H. Mohd Yasin, Juriyati Jalil, Jamia Azdina Jamal

Research output: Contribution to journalArticle

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Abstract

Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC50 values of less than 84 μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC50 values of 37.5, 60.9 and 45.7 μM, respectively.

Original languageEnglish
Pages (from-to)306-309
Number of pages4
JournalPhytomedicine
Volume15
Issue number4
DOIs
Publication statusPublished - 25 Apr 2008

Fingerprint

Zingiberaceae
platelet aggregation
Platelets
arachidonic acid
Platelet Aggregation
Arachidonic Acid
Curcuma
Curcumin
curcumin
Agglomeration
Xanthorhiza
Adenosine Diphosphate
Inhibitory Concentration 50
inhibitory concentration 50
collagen
Zingiber zerumbet
Blood
Collagen
Alpinia
Kaempferia

Keywords

  • Antiplatelet aggregation
  • Arachidonic acid
  • Curcumin
  • Human whole blood
  • Xanthorrhizol
  • Zingiberaceae

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. / Jantan, Ibrahim; Raweh, S. M.; Sirat, H. M.; Jamil, S.; Mohd Yasin, Y. H.; Jalil, Juriyati; Jamal, Jamia Azdina.

In: Phytomedicine, Vol. 15, No. 4, 25.04.2008, p. 306-309.

Research output: Contribution to journalArticle

Jantan, Ibrahim ; Raweh, S. M. ; Sirat, H. M. ; Jamil, S. ; Mohd Yasin, Y. H. ; Jalil, Juriyati ; Jamal, Jamia Azdina. / Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. In: Phytomedicine. 2008 ; Vol. 15, No. 4. pp. 306-309.
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