Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding

Bushra Abdulkarim Moharam, Ibrahim Jantan, Juriyati Jalil, Fasihuddin Ahmad

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Phytochemical investigation on the bark of Goniothalamus tapis Miq. and G. uvaroides King has resulted in the isolation of eight styryl-lactones, (-)-cryptomeridiol, liriodenine, 3-methyl-1H-benz[f]indole-4,9-dione, (-)-stigmasterol and dimethyl terephthalate. The structures of the compounds were elucidated by spectroscopic techniques. The compounds were evaluated for their effect on platelet-activating factor (PAF) receptor binding on rabbit platelets using 3H-PAF as a ligand. Among the compounds tested, (-)-cryptomeridiol, (+)-goniothalamin and (+)-isoaltholactone exhibited a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)50 values of 17.5, 19.7 and 46.5μm, respectively. The inhibitory effects of the first two compounds were comparable to that obtained from the positive control, cedrol. The results indicated that these compounds were strong PAF receptor binding inhibitors.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalPhytotherapy Research
Volume26
Issue number5
DOIs
Publication statusPublished - May 2012

Fingerprint

Goniothalamus
Stigmasterol
Platelet Activating Factor
Phytochemicals
Lactones
Inhibitory Concentration 50
Blood Platelets
Rabbits
Ligands
platelet activating factor receptor
cryptomeridiol

Keywords

  • (+)-goniothalamin
  • (-)-cryptomeridiol
  • Goniothalamus tapis (Annonaceae)
  • Goniothalamus uvaroides
  • PAF antagonistic activity

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding. / Moharam, Bushra Abdulkarim; Jantan, Ibrahim; Jalil, Juriyati; Ahmad, Fasihuddin.

In: Phytotherapy Research, Vol. 26, No. 5, 05.2012, p. 687-691.

Research output: Contribution to journalArticle

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